Academic Journal
Pharmacological Interventions for Anxiety and Depression in Terminal Illness: A Scoping Review of Randomized Controlled Trials.
| Τίτλος: | Pharmacological Interventions for Anxiety and Depression in Terminal Illness: A Scoping Review of Randomized Controlled Trials. |
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| Συγγραφείς: | Chowdhury O; Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada., Kyone K; Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada., Goldie C; Division of Palliative Medicine, Department of Medicine, Queen's University, Kingston, Ontario, Canada., Sinnarajah A; Division of Palliative Medicine, Department of Medicine, Queen's University, Kingston, Ontario, Canada.; Division of Palliative Care, Department of Medicine, Lakeridge Health, Oshawa, Ontario, Canada., Mathews J; Division of Palliative Medicine, Department of Medicine, Queen's University, Kingston, Ontario, Canada. |
| Πηγή: | Journal of pain & palliative care pharmacotherapy [J Pain Palliat Care Pharmacother] 2026 Sep; Vol. 40 (3), pp. 524-535. Date of Electronic Publication: 2026 May 20. |
| Τύπος έκδοσης: | Journal Article; Scoping Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101125608 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0539 (Electronic) Linking ISSN: 15360288 NLM ISO Abbreviation: J Pain Palliat Care Pharmacother Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: Binghamton, NY : Haworth Medical Press and Pharmaceutical Products Press, c2002- |
| Ιατρικοί όροι (MeSH): | Depression*/drug therapy , Depression*/etiology , Terminally Ill*/psychology , Anxiety*/drug therapy , Anxiety*/etiology , Terminal Care*/methods, Antidepressive Agents/therapeutic use ; Humans ; Randomized Controlled Trials as Topic ; Quality of Life |
| Περίληψη: | Anxiety and depression are highly prevalent among patients with chronic and progressive illnesses. At the terminal stage, these symptoms are closely linked with existential distress and can worsen quality of life. A scoping review of randomized controlled trials (RCTs) reporting on pharmacological interventions for anxiety and depression in terminal illnesses was conducted. MEDLINE, Embase, and CENTRAL databases were searched from inception to September 2024. Two reviewers independently extracted data on study design, population, interventions, and outcomes. Thirteen RCTs involving 621 participants were included. Eight studies included patients with advanced cancer, two included patients with end-stage renal disease, two included patients with advanced Human Immunodeficiency Virus, and one included patients with severe Chronic Obstructive Pulmonary Disease. The most studied drug classes were selective serotonin reuptake inhibitors and psychostimulants (5 of each). Overall, 10 of 13 studies reported statistically significant improvement in depression or anxiety. Pharmacological interventions improved depression and anxiety in terminal illness. Larger RCTs in non-cancer populations, particularly advanced heart disease, cerebrovascular disease, and dementia, which represent leading causes of morbidity and mortality globally, are needed. Studies should include drug classes commonly used in clinical practice such as noradrenaline and specific serotonergic antidepressants, serotonin-norepinephrine reuptake inhibitors, and benzodiazepines. |
| Contributed Indexing: | Keywords: Pharmacological interventions; anxiety; depression; review; terminal illness |
| Substance Nomenclature: | 0 (Antidepressive Agents) |
| Entry Date(s): | Date Created: 20260520 Date Completed: 20260824 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1080/15360288.2026.2669182 |
| PMID: | 42159384 |
| Βάση Δεδομένων: | MEDLINE |
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