Academic Journal
Propagation effects of abnormal beta oscillations on sleep rhythms in Parkinson's disease: A computational study.
| Τίτλος: | Propagation effects of abnormal beta oscillations on sleep rhythms in Parkinson's disease: A computational study. |
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| Συγγραφείς: | Wang H; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Intelligent Power Distribution Equipment and System, Hebei University of Technology, Tianjin 300401, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China. Electronic address: wanghongbin@hebut.edu.cn., An S; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China., Liu H; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China., Xu H; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China., Zhao Q; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China., Zhang A; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Intelligent Power Distribution Equipment and System, Hebei University of Technology, Tianjin 300401, China., Zhang S; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Intelligent Power Distribution Equipment and System, Hebei University of Technology, Tianjin 300401, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China. Electronic address: zs@hebut.edu.cn., Xu G; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Intelligent Power Distribution Equipment and System, Hebei University of Technology, Tianjin 300401, China; Hebei Key Laboratory of Bioelectromagnetics and Neural Engineering, Hebei University of Technology, Tianjin 300130, China; Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China. |
| Πηγή: | Neuroscience [Neuroscience] 2026 Aug 04; Vol. 608, pp. 118-142. Date of Electronic Publication: 2026 May 20. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| Imprint Name(s): | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| Ιατρικοί όροι (MeSH): | Beta Rhythm*/physiology , Parkinson Disease*/physiopathology , Sleep*/physiology , Computer Simulation* , Models, Neurological*, Neural Pathways/physiopathology ; Basal Ganglia/physiopathology ; Humans ; Animals |
| Περίληψη: | Parkinson's disease (PD) is characterized by abnormal beta oscillations (13-30 Hz) within the basal ganglia, which contribute not only to motor symptoms but also to sleep disturbances. In this study, we developed a computational model of the basal ganglia-thalamocortical (BGTC) network that includes the pedunculopontine nucleus (PPN), to investigate the mechanism by which the abnormal oscillations disrupt sleep. The model incorporates key nuclei, neurotransmitter systems, and neural pathways to simulate sleep-related brain activity in Parkinsonian conditions. Our simulations show that abnormal beta oscillations impair sleep across all vigilance states. During wakefulness, elevated beta activity in the basal ganglia and cortex prolongs sleep latency. In rapid eye movement (REM) sleep, reduced firing in the pedunculopontine nucleus combined with enhanced beta oscillations underlies features of REM sleep behavior disorder (RBD). In Non-REM 2 (N2) sleep, the formation of sleep spindles is reduced and shifted toward higher frequencies, promoting sleep fragmentation. In Non-REM 3 (N3) sleep, slow-wave amplitude decreases, indicating reduced depth. Propagation analysis reveals that the neural pathways Lhx6-cortical inhibitory neurons (IN), PPN-thalamic reticular nucleus (RE), and globus pallidus internus (GPi)-thalamocortex (TC) can facilitate the propagation of beta oscillations to cortex, while the GPi-TC pathway suppresses it during wakefulness, REM, and N2 sleep. Additionally, the pathway Lhx6-cortical pyramidal neurons (PY) inhibits beta propagation during wakefulness but promotes it during other sleep stages. These findings identify specific pathways through which abnormal beta oscillations propagate and disrupt thalamocortical sleep rhythms, providing new insights into the mechanisms underlying sleep disturbances in Parkinson's disease and highlighting potential therapeutic targets. (Copyright © 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Contributed Indexing: | Keywords: Beta oscillation; Computational model; Parkinson’s disease; Sleep disorder |
| Entry Date(s): | Date Created: 20260519 Date Completed: 20260613 Latest Revision: 20260630 |
| Update Code: | 20260701 |
| DOI: | 10.1016/j.neuroscience.2026.05.012 |
| PMID: | 42155843 |
| Βάση Δεδομένων: | MEDLINE |
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