Academic Journal
Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes.
| Τίτλος: | Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes. |
|---|---|
| Συγγραφείς: | Lee IW; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia. inwon.lee1@monash.edu., Nazari M; Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, Australia., Yuson J; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Uthishtran S; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.; European Molecular Biological Laboratory Australia (EMBL Australia), Monash University, Melbourne, VIC, Australia., Stocker R; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Adhikari D; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia., Wang ZW; Department of Cell and Developmental Biology and Consortium for Mitochondrial Research, University College London, London, UK., Szabadkai G; Department of Cell and Developmental Biology and Consortium for Mitochondrial Research, University College London, London, UK., Duchen MR; Department of Cell and Developmental Biology and Consortium for Mitochondrial Research, University College London, London, UK., Arumugam S; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.; European Molecular Biological Laboratory Australia (EMBL Australia), Monash University, Melbourne, VIC, Australia., Nosrati R; Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, Australia., Carroll J; Development and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia. j.carroll@monash.edu. |
| Πηγή: | Nature communications [Nat Commun] 2026 May 18; Vol. 17 (1). Date of Electronic Publication: 2026 May 18. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Oocytes*/metabolism , Oocytes*/cytology , Mitochondria*/metabolism , Actins*/metabolism , Chromatin*/metabolism , Cytoplasmic Streaming*/physiology, Myosins/metabolism ; Spindle Apparatus/metabolism ; Animals ; Female ; Xenopus laevis |
| Περίληψη: | Mitochondria are highly dynamic organelles, and their spatiotemporal organization is strictly regulated. While it has long been recognized that mitochondria in ovulated oocytes are concentrated in the spindle hemisphere, the mechanism remains unknown. Through live cell imaging and modeling, we have discovered that mitochondrial polarization in MII oocytes is achieved through two distinct mechanisms: (i) a mechanism in which mitochondria are transported by actin-driven cytoplasmic streaming that is delimited to the spindle hemisphere; (ii) an active, MYO19 dependent channeling mechanism that directs mitochondria from beneath the spindle to the polarized cortex bilaterally and perpendicular to the long axis of the MII spindle. This directionality in mitochondrial streaming patterns the ooplasm of the spindle hemisphere, creating mitochondria-rich and mitochondria-poor regions. These features explain the establishment of the polar gradient of mitochondria in MII oocytes and may provide new insight into the spatiotemporal organization of mitochondria in cells. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Grant Information: | 1165627 Department of Health | National Health and Medical Research Council (NHMRC); 200112 Department of Health | National Health and Medical Research Council (NHMRC) |
| Substance Nomenclature: | 0 (Actins) 0 (Chromatin) EC 3.6.4.1 (Myosins) |
| Entry Date(s): | Date Created: 20260518 Date Completed: 20260719 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13381949 |
| DOI: | 10.1038/s41467-026-73192-z |
| PMID: | 42151181 |
| Βάση Δεδομένων: | MEDLINE |
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