Academic Journal
Aberrant increased GABAergic neuronal activity in postrhinal cortex impairs spatial memory.
| Τίτλος: | Aberrant increased GABAergic neuronal activity in postrhinal cortex impairs spatial memory. |
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| Συγγραφείς: | Zhang J; Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China., Liu M; Department of Neurology, School of Medicine, Southeast University, Nanjing, China., Wang D; Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China., Shi M; Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Ye X; Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China., Ahmadzai S; Department of Neurology, School of Medicine, Southeast University, Nanjing, China., Qi X; Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China. Electronic address: qixinyang1988@sina.com. |
| Πηγή: | Behavioural brain research [Behav Brain Res] 2026 Aug 05; Vol. 511, pp. 116277. Date of Electronic Publication: 2026 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | GABAergic Neurons*/physiology , GABAergic Neurons*/metabolism , Spatial Memory*/physiology, Recognition, Psychology/physiology ; gamma-Aminobutyric Acid/metabolism ; Animals ; Male ; Rats |
| Περίληψη: | The postrhinal cortex (POR) in rodents is homologous with the primate parahippocampal cortex (PHC), and has been shown to play a crucial role in spatial and object recognition memory functions. Our previous study identified that POR glutamatergic neurons are specifically regulate spatial memory retrieval. However, the function of POR γ-aminobutyric acidergic (GABAergic) neurons in spatial and object recognition memory remains to be elucidated. In this study, we first confirmed that the POR contains plenty of GABAergic neurons. Then we determined that hyperactivity of POR GABAergic neurons impairs spatial memory, without affecting object recognition memory. We observed that hyperactivity of POR GABAergic neurons might suppress surrounding neuronal activity, which may lead to impairment of spatial memory. These findings add to our understanding of the function and dysfunction of POR GABAergic neurons in spatial memory and provide new insights for future research on diseases related to spatial memory decline. (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Disclosure of conflicts of interest The authors declare no conflict of interest. |
| Contributed Indexing: | Keywords: GABAergic neurons; Parahippocampal cortex; Postrhinal cortex; Spatial memory |
| Substance Nomenclature: | 56-12-2 (gamma-Aminobutyric Acid) |
| Entry Date(s): | Date Created: 20260516 Date Completed: 20260604 Latest Revision: 20260604 |
| Update Code: | 20260605 |
| DOI: | 10.1016/j.bbr.2026.116277 |
| PMID: | 42142747 |
| Βάση Δεδομένων: | MEDLINE |
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