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The Hallmarks of aging: Paradigms and scientific progress.

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Τίτλος: The Hallmarks of aging: Paradigms and scientific progress.
Συγγραφείς: García-Barranquero P; Department of Philosophy, University of Malaga, Malaga, Spain. Electronic address: pablogarcia@uma.es., Luque VJ; Department of Philosophy, University of Valencia, Valencia, Spain.
Πηγή: Ageing research reviews [Ageing Res Rev] 2026 Jul; Vol. 119, pp. 103181. Date of Electronic Publication: 2026 May 14.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE
Imprint Name(s): Original Publication: Oxford, UK : Elsevier Science, c2002-
Ιατρικοί όροι (MeSH): Aging*/physiology , Aging*/pathology , Geroscience*, Humans ; Animals
Περίληψη: The Hallmarks of Aging framework has become a widely accepted schema within geroscience, organizing diverse mechanisms of cellular and molecular decline. This article examines whether the Hallmarks function as a scientific paradigm and, beyond that, whether they have enabled genuine scientific progress-an angle largely absents from current literature. Drawing on models from the philosophy of science, the article evaluates the framework's status and impact from multiple perspectives. From Kuhn, the Hallmarks act as exemplars within the damage paradigm, guiding "normal science" without instigating revolutionary change. From Lakatos, they form part of a protective belt that stabilizes a research programme rather than producing theoretical innovation. From Laudan, they help solve empirical problems but leave conceptual issues unresolved. From Kitcher, their success lies in rhetorical and institutional unification more than inferential structure. From Galison, they are best understood as an instrumental "trading zone" that enables cross-disciplinary coordination. In sum, while the Hallmarks have brought coherence and methodological infrastructure to aging research, they may also constrain conceptual imagination-raising critical questions about the field's long-term epistemic vitality.
(Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Aging; Damage; Geroscience; Hallmarks; Paradigm; Scientific progress
Entry Date(s): Date Created: 20260515 Date Completed: 20260610 Latest Revision: 20260610
Update Code: 20260611
DOI: 10.1016/j.arr.2026.103181
PMID: 42140441
Βάση Δεδομένων: MEDLINE
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  Data: The Hallmarks of Aging framework has become a widely accepted schema within geroscience, organizing diverse mechanisms of cellular and molecular decline. This article examines whether the Hallmarks function as a scientific paradigm and, beyond that, whether they have enabled genuine scientific progress-an angle largely absents from current literature. Drawing on models from the philosophy of science, the article evaluates the framework's status and impact from multiple perspectives. From Kuhn, the Hallmarks act as exemplars within the damage paradigm, guiding "normal science" without instigating revolutionary change. From Lakatos, they form part of a protective belt that stabilizes a research programme rather than producing theoretical innovation. From Laudan, they help solve empirical problems but leave conceptual issues unresolved. From Kitcher, their success lies in rhetorical and institutional unification more than inferential structure. From Galison, they are best understood as an instrumental "trading zone" that enables cross-disciplinary coordination. In sum, while the Hallmarks have brought coherence and methodological infrastructure to aging research, they may also constrain conceptual imagination-raising critical questions about the field's long-term epistemic vitality.<br /> (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.)
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  Data: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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