Academic Journal
Brain and C-type natriuretic peptide are expressed by the human placenta and are not altered with preeclampsia, fetal growth restriction, or placental hypoxia.
| Τίτλος: | Brain and C-type natriuretic peptide are expressed by the human placenta and are not altered with preeclampsia, fetal growth restriction, or placental hypoxia. |
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| Συγγραφείς: | Fato BR; Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia., de Alwis N; Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Northern Health, Epping, Victoria, 3076, Australia., Beard S; Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia., Kodila Z; Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia., Wong GP; Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia., Kaitu'u-Lino TJ; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia., Bubb KJ; Department of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, 3800, Australia; Victorian Heart Institute, Monash University, Clayton, Victoria, 3168, Australia., Hannan NJ; Therapeutics Discovery and Vascular Function in Pregnancy Group, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Department of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Northern Health, Epping, Victoria, 3076, Australia. Electronic address: nhannan@unimelb.edu.au. |
| Πηγή: | Placenta [Placenta] 2026 Jun 24; Vol. 181, pp. 108-118. Date of Electronic Publication: 2026 May 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3102 (Electronic) Linking ISSN: 01434004 NLM ISO Abbreviation: Placenta Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010- > : Amsterdam : Elsevier Original Publication: London W.B. Saunders. |
| Ιατρικοί όροι (MeSH): | Pre-Eclampsia*/metabolism , Placenta*/metabolism , Natriuretic Peptide, C-Type*/metabolism , Natriuretic Peptide, C-Type*/genetics , Fetal Growth Retardation*/metabolism , Natriuretic Peptide, Brain*/metabolism , Natriuretic Peptide, Brain*/genetics , Hypoxia*/metabolism, Receptors, Atrial Natriuretic Factor/metabolism ; Receptors, Atrial Natriuretic Factor/genetics ; Trophoblasts/metabolism ; RNA, Messenger/metabolism ; Humans ; Female ; Pregnancy ; Adult ; Atrial Natriuretic Factor Receptor B |
| Περίληψη: | Introduction: The natriuretic peptide system is a critical regulator of hemodynamic function. Yet its expression in the human placenta has had limited investigation, despite its clear relevance to pregnancy. Preeclampsia and fetal growth restriction are serious conditions of pregnancy, whereby placental dysfunction is central to their pathophysiology. Here, we set out to characterise expression of C-type natriuretic peptide (CNP) and Brain natriuretic peptide (BNP) in human placenta. Methods: CNP, BNP, NPR-B and NPR-C expression was assessed in placental tissue from preeclamptic (preterm n = 73; term n = 5), fetal growth restricted (preterm n = 20; term n = 6) and normotensive pregnancies (first trimester n = 11; preterm n = 13; term n = 44). Primary cytotrophoblasts (n = 3) and placental explants (n = 5) were cultured under normoxic (8% O Results: CNP, BNP, NPR-B and NPR-C mRNA were expressed in human placenta; their expression was not differentially altered in pathological pregnancies (preeclamptic or fetal growth restricted) or by hypoxia. There was minimal expression of NPR-B and NPR-C, with punctate localisation to the spiral arterioles of first trimester decidua, the cell column, syncytiotrophoblast and cytotrophoblast layer of the placenta. CNP expression was localised to the syncytiotrophoblast. Conclusion: The BNP and CNP system are expressed in human first trimester decidua and placenta throughout gestation; their gene expression was unaltered in pathological placentas and models of placental dysfunction. (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Grant Information: | Non-US Government Research Support type |
| Contributed Indexing: | Keywords: Brain natriuretic peptide; C-type natriuretic peptide; Fetal growth restriction; Placenta; Preeclampsia; Pregnancy |
| Substance Nomenclature: | 127869-51-6 (Natriuretic Peptide, C-Type) 114471-18-0 (Natriuretic Peptide, Brain) EC 4.6.1.2 (Receptors, Atrial Natriuretic Factor) EC 4.6.1.2 (Atrial Natriuretic Factor Receptor B) EC 4.6.1.2 (atrial natriuretic factor receptor C) 0 (RNA, Messenger) |
| Entry Date(s): | Date Created: 20260515 Date Completed: 20260612 Latest Revision: 20260721 |
| Update Code: | 20260722 |
| DOI: | 10.1016/j.placenta.2026.05.003 |
| PMID: | 42139878 |
| Βάση Δεδομένων: | MEDLINE |
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