Academic Journal
MEG Working Memory N-Back Task Revealed Functional Deficits in Children with Mild Traumatic Brain Injury.
| Τίτλος: | MEG Working Memory N-Back Task Revealed Functional Deficits in Children with Mild Traumatic Brain Injury. |
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| Συγγραφείς: | Huang MX; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA., Angeles-Quinto A; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA., Robb-Swan A; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA., Bigler ED; Department of Neurology, University of Utah, Salt Lake City, Utah, USA., Wilde EA; Department of Neurology, University of Utah, Salt Lake City, Utah, USA., Vaida F; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, California, USA., Troyer EA; Department of Psychiatry, University of California, San Diego, California, USA., Hesselink JR; Department of Radiology, University of California, San Diego, California, USA., Cheng CK; Department of Computer Science and Engineering, University of California, San Diego, California, USA., Meng W; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, California, USA., Zimmerman E; Department of Pediatrics, University of California, San Diego, California, USA., Max JE; Department of Psychiatry, University of California, San Diego, California, USA.; Department of Psychiatry, Rady Children's Hospital, San Diego, California, USA. |
| Πηγή: | Journal of neurotrauma [J Neurotrauma] 2026 Oct; Vol. 43 (19-20), pp. 1569-1582. Date of Electronic Publication: 2026 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE |
| Imprint Name(s): | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1988- |
| Ιατρικοί όροι (MeSH): | Magnetoencephalography*/methods , Memory, Short-Term*/physiology , Brain Concussion*/physiopathology , Brain Concussion*/complications , Memory Disorders*/etiology , Memory Disorders*/physiopathology, Humans ; Child ; Male ; Adolescent ; Female ; Neuropsychological Tests ; Prospective Studies |
| Περίληψη: | Mild traumatic brain injury (mTBI) is a leading cause of sustained cognitive complaints in children. However, the TBI-related mechanisms underlying persistent cognitive symptoms including working memory (WM) dysfunction are not fully understood. Few pediatric studies of WM deficits in mTBI have taken advantage of the temporal and frequency resolution afforded by electromagnetic measurements. Using magnetoencephalography (MEG) and an N-back WM task, we investigated functional abnormalities in children with mTBI within a 3-week post-injury period. Children aged 8-15 years with mTBI (n = 60) and orthopedic injury (OI) controls (n = 37) from consecutive admissions to an emergency department were studied prospectively. MEG source-magnitude images were obtained for alpha (8-12 Hz), beta (15-30 Hz), gamma (30-90 Hz), theta (4-7 Hz), and delta (1-4 Hz) frequency bands. Compared with OI controls, children with mTBI showed decreased MEG signals (hypoactivity) across frequency bands in the proper WM network including dorsolateral prefrontal cortex (dlPFC), anterior cingulate cortex, and supramarginal gyrus (SMG), but over-recruitment with increased MEG signals (hyperactivity) in the frontal pole and ventromedial prefrontal cortex. The MEG activity from dlPFC and SMG regions also correlated with changes in symptom scores between 3-week and 3-month behavioral exams. This is the first pediatric study showing MEG hypoactivity from the WM proper network and over recruitment outside the WM network. One mechanism that may explain these novel findings could be the gamma-aminobutyric acid (GABA)-ergic inhibitory interneuron injury, which may cause disinhibition in the WM neural network, directly eliminating synchronized signals that are normally evoked by stimuli. This MEG study of abnormal MEG responses evoked by WM N-back stimuli provides a new functional imaging marker for pediatric mTBI. |
| Competing Interests: | Author Disclosure StatementJ.E.M. provides expert testimony in cases of traumatic brain injury on an ad hoc basis for plaintiffs and defendants on a more or less equal ratio. This activity constitutes approximately 5% of his professional activities. No competing financial interests exist for the remaining authors. |
| Grant Information: | S10 OD034302 United States OD NIH HHS; I01 CX002035 United States CX CSRD VA; I01 CX000499 United States CX CSRD VA; R01 HD088438 United States HD NICHD NIH HHS; I01 RX001988 United States RX RRD VA |
| Contributed Indexing: | Keywords: magnetoencephalography; pediatric traumatic brain injury; working memory |
| Entry Date(s): | Date Created: 20260515 Date Completed: 20260903 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| DOI: | 10.1177/08977151261433776 |
| PMID: | 42138124 |
| Βάση Δεδομένων: | MEDLINE |
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