Academic Journal
Προβολή σε EDS

MEG Working Memory N-Back Task Revealed Functional Deficits in Children with Mild Traumatic Brain Injury.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: MEG Working Memory N-Back Task Revealed Functional Deficits in Children with Mild Traumatic Brain Injury.
Συγγραφείς: Huang MX; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA., Angeles-Quinto A; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA., Robb-Swan A; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA., Bigler ED; Department of Neurology, University of Utah, Salt Lake City, Utah, USA., Wilde EA; Department of Neurology, University of Utah, Salt Lake City, Utah, USA., Vaida F; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, California, USA., Troyer EA; Department of Psychiatry, University of California, San Diego, California, USA., Hesselink JR; Department of Radiology, University of California, San Diego, California, USA., Cheng CK; Department of Computer Science and Engineering, University of California, San Diego, California, USA., Meng W; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, California, USA., Zimmerman E; Department of Pediatrics, University of California, San Diego, California, USA., Max JE; Department of Psychiatry, University of California, San Diego, California, USA.; Department of Psychiatry, Rady Children's Hospital, San Diego, California, USA.
Πηγή: Journal of neurotrauma [J Neurotrauma] 2026 Oct; Vol. 43 (19-20), pp. 1569-1582. Date of Electronic Publication: 2026 May 15.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE
Imprint Name(s): Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: New York, NY : Mary Ann Liebert, c1988-
Ιατρικοί όροι (MeSH): Magnetoencephalography*/methods , Memory, Short-Term*/physiology , Brain Concussion*/physiopathology , Brain Concussion*/complications , Memory Disorders*/etiology , Memory Disorders*/physiopathology, Humans ; Child ; Male ; Adolescent ; Female ; Neuropsychological Tests ; Prospective Studies
Περίληψη: Mild traumatic brain injury (mTBI) is a leading cause of sustained cognitive complaints in children. However, the TBI-related mechanisms underlying persistent cognitive symptoms including working memory (WM) dysfunction are not fully understood. Few pediatric studies of WM deficits in mTBI have taken advantage of the temporal and frequency resolution afforded by electromagnetic measurements. Using magnetoencephalography (MEG) and an N-back WM task, we investigated functional abnormalities in children with mTBI within a 3-week post-injury period. Children aged 8-15 years with mTBI (n = 60) and orthopedic injury (OI) controls (n = 37) from consecutive admissions to an emergency department were studied prospectively. MEG source-magnitude images were obtained for alpha (8-12 Hz), beta (15-30 Hz), gamma (30-90 Hz), theta (4-7 Hz), and delta (1-4 Hz) frequency bands. Compared with OI controls, children with mTBI showed decreased MEG signals (hypoactivity) across frequency bands in the proper WM network including dorsolateral prefrontal cortex (dlPFC), anterior cingulate cortex, and supramarginal gyrus (SMG), but over-recruitment with increased MEG signals (hyperactivity) in the frontal pole and ventromedial prefrontal cortex. The MEG activity from dlPFC and SMG regions also correlated with changes in symptom scores between 3-week and 3-month behavioral exams. This is the first pediatric study showing MEG hypoactivity from the WM proper network and over recruitment outside the WM network. One mechanism that may explain these novel findings could be the gamma-aminobutyric acid (GABA)-ergic inhibitory interneuron injury, which may cause disinhibition in the WM neural network, directly eliminating synchronized signals that are normally evoked by stimuli. This MEG study of abnormal MEG responses evoked by WM N-back stimuli provides a new functional imaging marker for pediatric mTBI.
Competing Interests: Author Disclosure StatementJ.E.M. provides expert testimony in cases of traumatic brain injury on an ad hoc basis for plaintiffs and defendants on a more or less equal ratio. This activity constitutes approximately 5% of his professional activities. No competing financial interests exist for the remaining authors.
Grant Information: S10 OD034302 United States OD NIH HHS; I01 CX002035 United States CX CSRD VA; I01 CX000499 United States CX CSRD VA; R01 HD088438 United States HD NICHD NIH HHS; I01 RX001988 United States RX RRD VA
Contributed Indexing: Keywords: magnetoencephalography; pediatric traumatic brain injury; working memory
Entry Date(s): Date Created: 20260515 Date Completed: 20260903 Latest Revision: 20260903
Update Code: 20260903
DOI: 10.1177/08977151261433776
PMID: 42138124
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 42138124
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: MEG Working Memory N-Back Task Revealed Functional Deficits in Children with Mild Traumatic Brain Injury.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Huang+MX%22">Huang MX</searchLink>; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Angeles-Quinto+A%22">Angeles-Quinto A</searchLink>; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Robb-Swan+A%22">Robb-Swan A</searchLink>; Department of Radiology, University of California, San Diego, California, USA.; Radiology and Research Services, VA San Diego Healthcare System, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Bigler+ED%22">Bigler ED</searchLink>; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Wilde+EA%22">Wilde EA</searchLink>; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Vaida+F%22">Vaida F</searchLink>; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Troyer+EA%22">Troyer EA</searchLink>; Department of Psychiatry, University of California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Hesselink+JR%22">Hesselink JR</searchLink>; Department of Radiology, University of California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+CK%22">Cheng CK</searchLink>; Department of Computer Science and Engineering, University of California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Meng+W%22">Meng W</searchLink>; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health, University of California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Zimmerman+E%22">Zimmerman E</searchLink>; Department of Pediatrics, University of California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Max+JE%22">Max JE</searchLink>; Department of Psychiatry, University of California, San Diego, California, USA.; Department of Psychiatry, Rady Children's Hospital, San Diego, California, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228811626%22">Journal of neurotrauma</searchLink> [J Neurotrauma] 2026 Oct; Vol. 43 (19-20), pp. 1569-1582. <i>Date of Electronic Publication: </i>2026 May 15.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mary+Ann+Liebert%22">Mary Ann Liebert </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8811626 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-9042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208977151%22">08977151 </searchLink><i>NLM ISO Abbreviation: </i>J Neurotrauma <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: Larchmont, NY : Mary Ann Liebert<br /><i>Original Publication</i>: New York, NY : Mary Ann Liebert, c1988-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Magnetoencephalography%22">Magnetoencephalography*</searchLink>/<searchLink fieldCode="MM" term="%22Magnetoencephalography+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory%2C+Short-Term%22">Memory, Short-Term*</searchLink>/<searchLink fieldCode="MM" term="%22Memory%2C+Short-Term+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain+Concussion%22">Brain Concussion*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+Concussion+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain+Concussion%22">Brain Concussion*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+Concussion+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory+Disorders%22">Memory Disorders*</searchLink>/<searchLink fieldCode="MM" term="%22Memory+Disorders+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory+Disorders%22">Memory Disorders*</searchLink>/<searchLink fieldCode="MM" term="%22Memory+Disorders+physiopathology%22">physiopathology</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Child%22">Child</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Adolescent%22">Adolescent</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Neuropsychological+Tests%22">Neuropsychological Tests</searchLink> ; <searchLink fieldCode="MH" term="%22Prospective+Studies%22">Prospective Studies</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Mild traumatic brain injury (mTBI) is a leading cause of sustained cognitive complaints in children. However, the TBI-related mechanisms underlying persistent cognitive symptoms including working memory (WM) dysfunction are not fully understood. Few pediatric studies of WM deficits in mTBI have taken advantage of the temporal and frequency resolution afforded by electromagnetic measurements. Using magnetoencephalography (MEG) and an N-back WM task, we investigated functional abnormalities in children with mTBI within a 3-week post-injury period. Children aged 8-15 years with mTBI (n = 60) and orthopedic injury (OI) controls (n = 37) from consecutive admissions to an emergency department were studied prospectively. MEG source-magnitude images were obtained for alpha (8-12 Hz), beta (15-30 Hz), gamma (30-90 Hz), theta (4-7 Hz), and delta (1-4 Hz) frequency bands. Compared with OI controls, children with mTBI showed decreased MEG signals (hypoactivity) across frequency bands in the proper WM network including dorsolateral prefrontal cortex (dlPFC), anterior cingulate cortex, and supramarginal gyrus (SMG), but over-recruitment with increased MEG signals (hyperactivity) in the frontal pole and ventromedial prefrontal cortex. The MEG activity from dlPFC and SMG regions also correlated with changes in symptom scores between 3-week and 3-month behavioral exams. This is the first pediatric study showing MEG hypoactivity from the WM proper network and over recruitment outside the WM network. One mechanism that may explain these novel findings could be the gamma-aminobutyric acid (GABA)-ergic inhibitory interneuron injury, which may cause disinhibition in the WM neural network, directly eliminating synchronized signals that are normally evoked by stimuli. This MEG study of abnormal MEG responses evoked by WM N-back stimuli provides a new functional imaging marker for pediatric mTBI.
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Author Disclosure StatementJ.E.M. provides expert testimony in cases of traumatic brain injury on an ad hoc basis for plaintiffs and defendants on a more or less equal ratio. This activity constitutes approximately 5% of his professional activities. No competing financial interests exist for the remaining authors.
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: S10 OD034302 United States OD NIH HHS; I01 CX002035 United States CX CSRD VA; I01 CX000499 United States CX CSRD VA; R01 HD088438 United States HD NICHD NIH HHS; I01 RX001988 United States RX RRD VA
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>magnetoencephalography; pediatric traumatic brain injury; working memory
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260515 <i>Date Completed: </i>20260903 <i>Latest Revision: </i>20260903
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260903
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1177/08977151261433776
– Name: AN
  Label: PMID
  Group: ID
  Data: 42138124
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42138124
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/08977151261433776
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1569
    Subjects:
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Child
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Adolescent
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Neuropsychological Tests
        Type: general
      – SubjectFull: Prospective Studies
        Type: general
      – SubjectFull: Magnetoencephalography methods
        Type: general
      – SubjectFull: Memory, Short-Term physiology
        Type: general
      – SubjectFull: Brain Concussion physiopathology
        Type: general
      – SubjectFull: Brain Concussion complications
        Type: general
      – SubjectFull: Memory Disorders etiology
        Type: general
      – SubjectFull: Memory Disorders physiopathology
        Type: general
    Titles:
      – TitleFull: MEG Working Memory N-Back Task Revealed Functional Deficits in Children with Mild Traumatic Brain Injury.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Huang MX
      – PersonEntity:
          Name:
            NameFull: Angeles-Quinto A
      – PersonEntity:
          Name:
            NameFull: Robb-Swan A
      – PersonEntity:
          Name:
            NameFull: Bigler ED
      – PersonEntity:
          Name:
            NameFull: Wilde EA
      – PersonEntity:
          Name:
            NameFull: Vaida F
      – PersonEntity:
          Name:
            NameFull: Troyer EA
      – PersonEntity:
          Name:
            NameFull: Hesselink JR
      – PersonEntity:
          Name:
            NameFull: Cheng CK
      – PersonEntity:
          Name:
            NameFull: Meng W
      – PersonEntity:
          Name:
            NameFull: Zimmerman E
      – PersonEntity:
          Name:
            NameFull: Max JE
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1557-9042
          Numbering:
            – Type: volume
              Value: 43
            – Type: issue
              Value: 19-20
          Titles:
            – TitleFull: Journal of neurotrauma
              Type: main
ResultId 1