Academic Journal
Clinical applications and methodology updates in HLA typing.
| Τίτλος: | Clinical applications and methodology updates in HLA typing. |
|---|---|
| Συγγραφείς: | Feng K; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Chang L; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China., Yan Y; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China., Sun H; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China., Liu Y; Military Hospital of the People's Liberation Army, Xi'an, Shaanxi, 63750, P. R. China., Song S; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Nuermaimaiti A; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Halemubieke S; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Mei L; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Su Q; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Liu X; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China., Lu Z; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China., Ji H; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China. 18611420225@163.com.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China. 18611420225@163.com., Wang L; Beijing Hospital, National center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, National Center for Clinical Laboratories, National Clinical Research Center for Gerontology, Chinese Academy of Medical Sciences, Beijing, P.R. China. lunan99@163.com.; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P. R. China. lunan99@163.com.; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China. lunan99@163.com. |
| Πηγή: | BMC immunology [BMC Immunol] 2026 May 14; Vol. 27 (1). Date of Electronic Publication: 2026 May 14. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 100966980 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2172 (Electronic) Linking ISSN: 14712172 NLM ISO Abbreviation: BMC Immunol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2000- |
| Ιατρικοί όροι (MeSH): | Histocompatibility Testing*/methods , HLA Antigens*/genetics , HLA Antigens*/immunology, Polymerase Chain Reaction/methods ; Humans ; Polymorphism, Single Nucleotide ; High-Throughput Nucleotide Sequencing |
| Περίληψη: | The Human Leukocyte Antigen (HLA) system is a key component of the immune system, involving aspects such as autoimmune reactions, transplant rejection reactions, and related diseases. HLA typing technology enables precise decision-making in clinical tissue matching, disease susceptibility assessment, and drug response prediction. Therefore, this article summarizes the genetic characteristics of HLA, several commonly used methods for typing, including serological methods and molecular biology methods. It also explores the clinical applications of HLA typing, such as in organ and stem cell transplantation, blood transfusion, and disease association studies. In addition, in recent years, the combination of Single Nucleotide Polymorphism (SNP) and PCR technology has shown its potential application in various gene typing. In particular, the application of SNP-PCR method in HLA typing provides new possibilities for improving typing accuracy, reducing costs, and shortening detection time. Therefore, we summarize the existing HLA typing technologies and prospects for the future development of SNP-PCR method in HLA typing. With the continuous progress of bioinformatics and high-throughput sequencing technology, SNP-PCR is expected to become an efficient, economical, and widely used method for HLA typing, providing strong support for precision medicine. In addition, combined with big data analysis, SNP-PCR is expected to further reveal the complex associations between HLA and various diseases, thereby promoting in-depth research and development in immunology, genetics, and clinical medicine. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: This article does not involve Ethical Approval and consent to participate. Consent for publication: The submitted research is original and has not been published elsewhere. All authors agree to the content and publication of this paper. There is no conflict of interest among all authors. All authors agree to publish this review. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. |
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| Grant Information: | L244070 Beijing Natural Science Foundation |
| Contributed Indexing: | Keywords: Disease association; HLA typing; HLA typing methods; Transfusion; Transplant |
| Substance Nomenclature: | 0 (HLA Antigens) |
| Entry Date(s): | Date Created: 20260514 Date Completed: 20260717 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13374135 |
| DOI: | 10.1186/s12865-026-00845-5 |
| PMID: | 42135629 |
| Βάση Δεδομένων: | MEDLINE |
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