Academic Journal
Advances in MAPK pathway-targeted therapy for ameloblastoma: A literature review.
| Τίτλος: | Advances in MAPK pathway-targeted therapy for ameloblastoma: A literature review. |
|---|---|
| Συγγραφείς: | Lv Y; Department of Oral and Maxillofacial Surgery, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, China., Yang Z; Department of Oral and Maxillofacial Surgery, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, China., Pan Z; Department of Oral and Maxillofacial Surgery, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, China., Liu X; Department of Oral and Maxillofacial Surgery, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, China., Yu J; Department of Oral and Maxillofacial Surgery, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, China., Li B; Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, China; NHC Key Lab of Health Economics and Policy Research (Shandong University), China; Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank), China., Zhang F; Department of Oral and Maxillofacial Surgery, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Cheeloo College of Medicine, China. Electronic address: zfengh@sdu.edu.cn. |
| Πηγή: | Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2026 Oct; Vol. 127 (5), pp. 102829. Date of Electronic Publication: 2026 May 13. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101701089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7855 (Electronic) Linking ISSN: 24687855 NLM ISO Abbreviation: J Stomatol Oral Maxillofac Surg Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Issy les Moulineaux Cedex : Elsevier Masson SAS, [2017]- |
| Ιατρικοί όροι (MeSH): | Ameloblastoma*/genetics , Ameloblastoma*/drug therapy , Ameloblastoma*/therapy , Molecular Targeted Therapy*/methods , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/genetics , Jaw Neoplasms*/genetics , Jaw Neoplasms*/drug therapy, Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Protein Kinase Inhibitors/therapeutic use ; Humans ; Mutation ; Prognosis |
| Περίληψη: | Ameloblastoma (AM) is an odontogenic benign tumor with local invasiveness and high recurrence rate. Currently, surgical resection remains the mainstay of treatment; however, high postoperative recurrence rates and the need for multiple surgeries often result in facial deformity and psychological distress. Therefore, it is of great significance to explore effective non-surgical treatment methods with few side effects. In recent years, studies have found that the abnormal activation of the MAPK signaling pathway, especially the BRAF V600E mutation, is closely related to the occurrence, progression and prognosis of ameloblastoma, and has become a key target for treatment. As an emerging non-surgical strategy, targeted therapy has shown significant therapeutic potential by inhibiting abnormally activated signaling pathways. This article focuses on the molecular pathogenesis related to the MAPK signaling pathway and the progress of targeted therapy, and comprehensively reviews the mutation sites in ameloblastoma and the corresponding targeted drugs, aiming to provide references for clinical treatment, form a three-dimensional matching system of "mutant gene - drug target - clinical effect", so as to provide new therapeutic ideas and methods for clinical practice and improve the prognosis and quality of life of patients. (Copyright © 2026 Elsevier Masson SAS. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Ameloblastoma; BRAF V600E; BRAF inhibitor; Mitogen-activated protein kinase signaling pathway; Targeted therapy |
| Substance Nomenclature: | EC 2.7.11.1 (Proto-Oncogene Proteins B-raf) EC 2.7.11.1 (BRAF protein, human) 0 (Protein Kinase Inhibitors) |
| Entry Date(s): | Date Created: 20260514 Date Completed: 20261005 Latest Revision: 20261005 |
| Update Code: | 20261006 |
| DOI: | 10.1016/j.jormas.2026.102829 |
| PMID: | 42134541 |
| Βάση Δεδομένων: | MEDLINE |
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