Academic Journal
Recommendations From the Implementation Steering Group for Organ Utilisation Histocompatibility and Immunogenetics Sub-Group: ISOU H&I Sub-Group Recommendations.
| Τίτλος: | Recommendations From the Implementation Steering Group for Organ Utilisation Histocompatibility and Immunogenetics Sub-Group: ISOU H&I Sub-Group Recommendations. |
|---|---|
| Συγγραφείς: | Speirs NC; H&I Laboratory, SNBTS, Edinburgh Royal Infirmary, NHS National Services Scotland, Edinburgh, UK., Chalker V; NHS England, London, UK., Clark B; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Courtney AE; Regional Nephrology & Transplant Unit, Belfast City Hospital, Belfast, UK., Daga S; Leeds Teaching Hospitals NHS Trust, Leeds, UK.; University of Leeds, Leeds, UK., Griffin S; Cardiff and Vale University Health Board, Cardiff, UK., Kallon D; Clinical Transplantation Laboratory, NHS East and South East London Pathology Partnership, Barts Health NHS Trust, London, UK., Kim JJ; Department of Surgery, University of Cambridge, Cambridge, UK.; Department of Paediatric Nephrology, Nottingham University Hospital, Nottingham, UK., Kosmoliaptsis V; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, University of Cambridge, Cambridge, UK., Latham K; NHS Blood and Transplant, London, UK., Peacock S; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Shaw O; Clinical Transplantation Laboratory, Guys Hospital, Synnovis, London, UK., Nieto T; Department of Renal Transplant Surgery, Queen Elizabeth Hospital, Birmingham, UK., Ravanan R; North Bristol NHS Trust, Bristol, UK., Battle R; H&I Laboratory, SNBTS, Edinburgh Royal Infirmary, NHS National Services Scotland, Edinburgh, UK. |
| Πηγή: | International journal of immunogenetics [Int J Immunogenet] 2026 Aug; Vol. 53 (4), pp. 324-331. Date of Electronic Publication: 2026 May 14. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-313X (Electronic) Linking ISSN: 17443121 NLM ISO Abbreviation: Int J Immunogenet Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Blackwell Pub., c2005- |
| Ιατρικοί όροι (MeSH): | Histocompatibility Testing*/methods , Histocompatibility Testing*/standards , Immunogenetics*/methods , HLA Antigens*/immunology , HLA Antigens*/genetics , Histocompatibility*/genetics , Histocompatibility*/immunology , Organ Transplantation* , Tissue and Organ Procurement*, Humans ; United Kingdom ; Tissue Donors |
| Περίληψη: | The Organ Utilisation Group was established to address barriers in solid organ transplantation and improve patient outcomes across the United Kingdom. The group produced a series of recommendations in February 2023. To address these recommendations, the Department of Health and Social Care formed the Implementation Steering Group for Organ Utilisation (ISOU). A dedicated Histocompatibility and Immunogenetics (H&I) sub-group was formed with a remit to provide recommendations for HLA compatibility assessments and new technologies that could improve patient outcomes, within a 5 to 10 year time frame. The ISOU H&I sub-group made five key recommendations, grouped under three themes: (1) implementation and digital capture of high-resolution HLA typing data for organ donor and recipients; (2) utilising high-resolution HLA typing data to improve donor/recipient compatibility assessment and patient outcomes and (3) use of other technologies/innovations to improve patient outcomes. This article discusses the recommendations with an emphasis on advanced technologies and methodologies such as high-resolution HLA typing, molecular matching, non-HLA antigen systems, donor-derived cell-free DNA (dd-cfDNA) and artificial intelligence (AI). Implementation of these recommendations aims to enhance organ matching, reduce immunological risk and improve equity and long-term outcomes for transplant recipients and position UK transplantation services at the forefront of innovation and patient-centred care. (© 2026 John Wiley & Sons Ltd.) |
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| Contributed Indexing: | Keywords: HLA; ISOU; dd‐cfDNA; recommendations |
| Substance Nomenclature: | 0 (HLA Antigens) |
| Entry Date(s): | Date Created: 20260514 Date Completed: 20260710 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13352101 |
| DOI: | 10.1111/iji.70054 |
| PMID: | 42132187 |
| Βάση Δεδομένων: | MEDLINE |
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