Academic Journal
Histomorphometric Effects of Thymoquinone and High-Frequency Vibration on Bone Formation During Retention After Rapid Palatal Expansion: A Controlled Rat Study.
| Τίτλος: | Histomorphometric Effects of Thymoquinone and High-Frequency Vibration on Bone Formation During Retention After Rapid Palatal Expansion: A Controlled Rat Study. |
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| Συγγραφείς: | Özdal Zincir Ö; Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul University-Cerrahpaşa, Istanbul, Turkey., Paşaoğlu Bozkurt A; Faculty of Dentistry, Department of Orthodontics, Istanbul Aydin University, Istanbul, Turkey., Emincik A; Faculty of Medicine, Department of Histology and Embryology, Istanbul Beykent University, Istanbul, Turkey. |
| Πηγή: | Orthodontics & craniofacial research [Orthod Craniofac Res] 2026 Oct; Vol. 29 (5), pp. 917-925. Date of Electronic Publication: 2026 May 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Munksgaard Country of Publication: England NLM ID: 101144387 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-6343 (Electronic) Linking ISSN: 16016335 NLM ISO Abbreviation: Orthod Craniofac Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Blackwell Munksgaard, c2002- |
| Ιατρικοί όροι (MeSH): | Benzoquinones*/pharmacology , Vibration*/therapeutic use , Osteogenesis*/drug effects , Palatal Expansion Technique*, Osteoblasts/drug effects ; Osteoclasts/drug effects ; Osteocalcin/analysis ; Animals ; Male ; Rats, Wistar ; Rats ; Random Allocation |
| Περίληψη: | Objective: Relapse after rapid palatal expansion (RPE) is associated with insufficient bone formation in the midpalatal suture during retention. This study evaluated the effects of thymoquinone (TQ) and high-frequency vibration force (VF) on bone formation after RPE in a rat model. Methods: 24 male Wistar rats were randomly divided into three groups (n = 8): control (RPE only), vibration (RPE + 111 Hz vibration) and TQ (RPE + TQ). RPE was performed for 5 days with a 50-g force followed by a 12-day retention period. VF was applied for 20 min/day during retention, while TQ was administered orogastrically at 10 mg/kg/day. Histomorphometric analysis included osteoblast, osteoclast, and capillary numbers, mineralized area, fibrous area, and osteocalcin immunoreactivity. Data were analysed using ANOVA or Kruskal-Wallis tests with Bonferroni correction (α = 0.05). Results: Both VF and TQ groups showed significantly higher osteoblast counts than the control group (VF: 20.5 ± 3.56; TQ: 19.3 ± 2.80; control: 10.6 ± 2.16; p < 0.001). Capillary numbers were also higher in the VF (9.83 ± 2.78) and TQ groups (10.0 ± 2.82) than in the control group (3.50 ± 1.76) (p < 0.01). Mineralized area values were greater in the VF (41.06 ± 5.58) and TQ groups (38.35 ± 8.48) than in the control group (23.77 ± 3.37) (p < 0.001). Fibrous area values were lower in both experimental groups (p < 0.01). Conclusions: TQ and high-frequency vibration enhanced bone formation and angiogenesis during retention after RPE. These approaches may represent adjunctive strategies to improve post-expansion bone remodelling, although further clinical studies are required. (© 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| Contributed Indexing: | Keywords: bone regeneration; orthodontic relapse; rapid palatal expansion; rat model; thymoquinone; vibration therapy |
| Substance Nomenclature: | 0 (Benzoquinones) O60IE26NUF (thymoquinone) 104982-03-8 (Osteocalcin) |
| Entry Date(s): | Date Created: 20260513 Date Completed: 20260904 Latest Revision: 20260906 |
| Update Code: | 20260906 |
| PubMed Central ID: | PMC13543174 |
| DOI: | 10.1111/ocr.70139 |
| PMID: | 42126285 |
| Βάση Δεδομένων: | MEDLINE |
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