Academic Journal
Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.
| Τίτλος: | Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network. |
|---|---|
| Συγγραφείς: | Lohse M; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK., Willmore BDB; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., King AJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. andrew.king@dpag.ox.ac.uk. |
| Πηγή: | Nature reviews. Neuroscience [Nat Rev Neurosci] 2026 Jul; Vol. 27 (7), pp. 465-480. Date of Electronic Publication: 2026 May 11. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0048 (Electronic) Linking ISSN: 1471003X NLM ISO Abbreviation: Nat Rev Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, UK : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Auditory Pathways*/physiology , Auditory Cortex*/physiology , Auditory Perception*/physiology , Nerve Net*/physiology, Humans ; Animals |
| Περίληψη: | Mammalian sensory systems are traditionally viewed as hierarchical pathways in which subcortical nuclei relay signals from peripheral receptors to the cortex, where sensory information is contextualized for perception and behaviour. However, the auditory pathway contains an unusually large number of anatomically complex, recurrently connected subcortical nuclei that transmit heavily pre-processed information to the cortex. Emerging evidence shows that the auditory system functions as an integrated cortical-subcortical network that is heavily influenced by non-auditory inputs and extensive bidirectional connectivity at nearly all levels. Subcortical structures are not passive relays but active participants in computations traditionally attributed to cortex, including adaptive coding of sound statistics, multisensory integration, encoding of behavioural relevance and action, and learning. Although certain transformations occur hierarchically - such as brainstem spatial processing - sensitivity to most sound features forms a continuum across the auditory pathway, with modulation by other sensory, motor and cognitive systems at every stage. The degree of subcortical pre-processing may explain why emergent cortical properties are harder to identify in audition than in vision, in which cortical and subcortical receptive field properties are more distinct. This distributed circuit organization opens new avenues for understanding how the brain constructs perception and guides behaviour from the fusion of sensory evidence and contextual knowledge. (© 2026. Springer Nature Limited.) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Entry Date(s): | Date Created: 20260511 Date Completed: 20260624 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1038/s41583-026-01045-1 |
| PMID: | 42115343 |
| Βάση Δεδομένων: | MEDLINE |
| FullText | Text: Availability: 0 |
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| Header | DbId: cmedm DbLabel: MEDLINE An: 42115343 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lohse+M%22">Lohse M</searchLink>; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Willmore+BDB%22">Willmore BDB</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22King+AJ%22">King AJ</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. andrew.king@dpag.ox.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100962781%22">Nature reviews. Neuroscience</searchLink> [Nat Rev Neurosci] 2026 Jul; Vol. 27 (7), pp. 465-480. <i>Date of Electronic Publication: </i>2026 May 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Review – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100962781 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-0048 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221471003X%22">1471003X </searchLink><i>NLM ISO Abbreviation: </i>Nat Rev Neurosci <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: London, UK : Nature Pub. Group – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Auditory+Pathways%22">Auditory Pathways*</searchLink>/<searchLink fieldCode="MM" term="%22Auditory+Pathways+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Auditory+Cortex%22">Auditory Cortex*</searchLink>/<searchLink fieldCode="MM" term="%22Auditory+Cortex+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Auditory+Perception%22">Auditory Perception*</searchLink>/<searchLink fieldCode="MM" term="%22Auditory+Perception+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Nerve+Net%22">Nerve Net*</searchLink>/<searchLink fieldCode="MM" term="%22Nerve+Net+physiology%22">physiology</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Mammalian sensory systems are traditionally viewed as hierarchical pathways in which subcortical nuclei relay signals from peripheral receptors to the cortex, where sensory information is contextualized for perception and behaviour. However, the auditory pathway contains an unusually large number of anatomically complex, recurrently connected subcortical nuclei that transmit heavily pre-processed information to the cortex. Emerging evidence shows that the auditory system functions as an integrated cortical-subcortical network that is heavily influenced by non-auditory inputs and extensive bidirectional connectivity at nearly all levels. Subcortical structures are not passive relays but active participants in computations traditionally attributed to cortex, including adaptive coding of sound statistics, multisensory integration, encoding of behavioural relevance and action, and learning. Although certain transformations occur hierarchically - such as brainstem spatial processing - sensitivity to most sound features forms a continuum across the auditory pathway, with modulation by other sensory, motor and cognitive systems at every stage. The degree of subcortical pre-processing may explain why emergent cortical properties are harder to identify in audition than in vision, in which cortical and subcortical receptive field properties are more distinct. This distributed circuit organization opens new avenues for understanding how the brain constructs perception and guides behaviour from the fusion of sensory evidence and contextual knowledge.<br /> (© 2026. Springer Nature Limited.) – Name: Abstract Label: Competing Interests Group: Ab Data: Competing interests: The authors declare no competing interests. – Name: Ref Label: References Group: RefInfo Data: Curr Biol. 2024 Aug 5;34(15):3405-3415.e5. (PMID: <searchLink fieldCode="PM" term="%2239032492%22">39032492)</searchLink><br />Hear Res. 2017 Feb;344:275-283. (PMID: <searchLink fieldCode="PM" term="%2227964936%22">27964936)</searchLink><br />Nat Neurosci. 2005 Dec;8(12):1684-9. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41583-026-01045-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 465 Subjects: – SubjectFull: Humans Type: general – SubjectFull: Animals Type: general – SubjectFull: Auditory Pathways physiology Type: general – SubjectFull: Auditory Cortex physiology Type: general – SubjectFull: Auditory Perception physiology Type: general – SubjectFull: Nerve Net physiology Type: general Titles: – TitleFull: Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lohse M – PersonEntity: Name: NameFull: Willmore BDB – PersonEntity: Name: NameFull: King AJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1471-0048 Numbering: – Type: volume Value: 27 – Type: issue Value: 7 Titles: – TitleFull: Nature reviews. Neuroscience Type: main |
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