Clinical significance of soluble E-selectin and soluble vascular cell adhesion molecule-1 levels in umbilical cord blood for neonatal respiratory distress syndrome: a retrospective study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Clinical significance of soluble E-selectin and soluble vascular cell adhesion molecule-1 levels in umbilical cord blood for neonatal respiratory distress syndrome: a retrospective study.
Συγγραφείς:	Huang Q; Department of General Pediatrics, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou City, Jiangsu Province, China., Qin Y; Department of General Pediatrics, Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou City, Jiangsu Province, China.
Πηγή:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2026 Dec; Vol. 39 (1), pp. 2660017. Date of Electronic Publication: 2026 May 10.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE
Imprint Name(s):	Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002-
Ιατρικοί όροι (MeSH):	E-Selectin/blood , Respiratory Distress Syndrome, Newborn/blood , Respiratory Distress Syndrome, Newborn/diagnosis , Vascular Cell Adhesion Molecule-1/blood , Fetal Blood/chemistry , Fetal Blood/metabolism, Biomarkers/blood ; Infant, Premature/blood ; Humans ; Retrospective Studies ; Infant, Newborn ; Female ; Male ; Prognosis ; Apgar Score ; ROC Curve
Περίληψη:	Objective: This study evaluates the clinical significance of soluble E-selectin (sE-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in umbilical cord blood for neonatal respiratory distress syndrome (NRDS). Methods: This retrospective single-center study collected 558 preterm infants, categorized into NRDS (n = 162) and non-NRDS (n = 396) groups. sE-selectin and sVCAM-1 levels in umbilical cord blood were measured. Their correlations with the 5-minute Apgar score and PaO2/FiO2 ratio were assessed using Spearman/Pearson analysis. ROC curves were generated to assess their predictive value for NRDS diagnosis and discriminatory value for 28-day prognosis. Logistic and Poisson regression models were used to identify risk factors for poor prognosis. Results: sE-selectin and sVCAM-1 were elevated in NRDS infants and positively correlated with disease severity. They showed negative correlations with 5-minute Apgar score and PaO2/FiO2 ratio. For NRDS prediction, the AUC was 0.894 for sE-selectin and 0.878 for sVCAM-1. sE-selectin combined with sVCAM-1 achieved an AUC of 0.935. For discriminating poor 28-day prognosis, the AUC was 0.867 for sE-selectin and 0.878 for sVCAM-1. The combined AUC of 0.913 was higher than that of any biomarker alone. sE-selectin (OR: 1.163, 95%CI: 1.057 ∼ 1.279), sVCAM-1 (OR: 1.097, 95%CI: 1.035 ∼ 1.163), and 5-minute Apgar score (OR: 0.408, 95%CI: 0.269 ∼ 0.620) were independently associated with poor prognosis. Poisson regression analysis results in the generalized linear model were consistent with the conclusions of the logistic regression analysis. Conclusion: sE-selectin and sVCAM-1 are elevated in umbilical cord blood in NRDS infants and closely correlated with disease severity and 28-day prognosis.
Contributed Indexing:	Keywords: Soluble E-selectin; diagnosis; logistic regression; neonatal respiratory distress syndrome; prognosis; soluble vascular cell adhesion molecule-1
Substance Nomenclature:	0 (E-Selectin) 0 (Vascular Cell Adhesion Molecule-1) 0 (Biomarkers)
Entry Date(s):	Date Created: 20260510 Date Completed: 20260716 Latest Revision: 20260716
Update Code:	20260717
DOI:	10.1080/14767058.2026.2660017
PMID:	42108382
Βάση Δεδομένων:	MEDLINE

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