Academic Journal
Terpenoids in Euphorbia milii Ch. des Moulins and their anti-rheumatic potential.
| Τίτλος: | Terpenoids in Euphorbia milii Ch. des Moulins and their anti-rheumatic potential. |
|---|---|
| Συγγραφείς: | Su HY; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Deng MY; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Wang X; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Huang S; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China., Chen L; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; School of Life Science and Engineering, Yibin Institute of Southwest Jiaotong University, Yibin, 644000, China. Electronic address: linch@swjtu.edu.cn., Zhou XL; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; School of Life Science and Engineering, Yibin Institute of Southwest Jiaotong University, Yibin, 644000, China. Electronic address: zhouxl@swjtu.edu.cn. |
| Πηγή: | Phytochemistry [Phytochemistry] 2026 Oct; Vol. 250, pp. 114947. Date of Electronic Publication: 2026 May 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Euphorbia*/chemistry , Terpenes*/chemistry , Terpenes*/pharmacology , Terpenes*/isolation & purification , Antirheumatic Agents*/chemistry , Antirheumatic Agents*/pharmacology , Antirheumatic Agents*/isolation & purification, Molecular Structure ; Humans |
| Περίληψη: | Seven previously undescribed terpenoids (1-7) and sixteen known terpenoids (8-23) were isolated from Euphorbia milii Ch. des Moulins. Among the undescribed terpenoids, there is one eremophilane-type sesquiterpenoid: (4R,5R,7R)-7β-hydroxy-eremophil-1(10),11-diene-2-one (1); one abietane-type diterpenoid: 9-hydroxycaudicifolin (2); one taxane-type diterpenoid: euphominoid Q (3); three norrosane-type diterpenoids: 19-norrosa-5,15-diene-3α,4β-dihydroxy-1,6-dione (4), 19-norrosa-5,15-diene-3α,4α-dihydroxy-1,6-dione (5), 19-norrosa-1,5,15-triene-3α,4α-diol (6); and one taraxerane triterpenoid: aleuritolic acid-3-cis-p-hydroxycinnamate (7). The structures of these compounds were elucidated including nuclear magnetic resonance (NMR), mass spectrometry, X-ray single-crystal diffraction, and calculated 13C-NMR. Among them, euphominoid Q (3) represents a rare 6/12-fused taxane-type diterpenoid, while 19-norrosa-5,15-diene-3α,4β-dihydroxy-1,6-dione (4) and 19-norrosa-5,15-diene-3α,4α-dihydroxy-1,6-dione (5) are epimers. In vitro bioactivity assays revealed that 9-hydroxycaudicifolin (2) and caudicifolin (20), two abietane-type diterpenoids with anti-rheumatic potential, exhibited stronger inhibitory effects on the production of the inflammatory cytokine NO at 50 μM than the positive control celecoxib. Furthermore, both compounds inhibited the proliferation of MH7A cells, which are synovial fibroblasts derived from rheumatoid arthritis patients. Preliminary observations indicated that compound 2 could induce apoptosis in MH7A cells, arrest the cell cycle of MH7A cells at the G2 phase in a concentration-dependent manner. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no competing financial interest. |
| Contributed Indexing: | Keywords: Anti-rheumatic potential; Calculated (13)C-NMR; Euphorbia milii Ch. des Moulins; Euphorbiaceae; Terpenoids |
| Substance Nomenclature: | 0 (Terpenes) 0 (Antirheumatic Agents) |
| Entry Date(s): | Date Created: 20260508 Date Completed: 20260719 Latest Revision: 20260719 |
| Update Code: | 20260720 |
| DOI: | 10.1016/j.phytochem.2026.114947 |
| PMID: | 42103088 |
| Βάση Δεδομένων: | MEDLINE |
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