Academic Journal
Effects of electroconvulsive therapy on cerebellar-cerebral functional connectivity in patients with treatment-resistant depression and their correlations with gene expression profiles.
| Τίτλος: | Effects of electroconvulsive therapy on cerebellar-cerebral functional connectivity in patients with treatment-resistant depression and their correlations with gene expression profiles. |
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| Συγγραφείς: | Zhang L; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Han Y; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Lv D; Inner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China., Yao P; Inner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China., Chen L; Inner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China., Yuan Y; Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China., Zhao J; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Guo W; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China., Guo Z; Inner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China., Ou Y; Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. |
| Πηγή: | Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2026 Aug; Vol. 80 (8), pp. 655-664. Date of Electronic Publication: 2026 May 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9513551 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1819 (Electronic) Linking ISSN: 13231316 NLM ISO Abbreviation: Psychiatry Clin Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Carlton, Vic., Australia : Blackwell Science |
| Ιατρικοί όροι (MeSH): | Depressive Disorder, Treatment-Resistant*/therapy , Depressive Disorder, Treatment-Resistant*/diagnostic imaging , Depressive Disorder, Treatment-Resistant*/physiopathology , Depressive Disorder, Treatment-Resistant*/genetics , Cerebellum*/diagnostic imaging , Cerebellum*/physiopathology , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging , Cerebral Cortex*/diagnostic imaging , Cerebral Cortex*/physiopathology , Default Mode Network*/diagnostic imaging , Default Mode Network*/physiopathology , Electroconvulsive Therapy* , Connectome* , Transcriptome*, Humans ; Female ; Male ; Adult ; Middle Aged ; Magnetic Resonance Imaging |
| Περίληψη: | Aims: Electroconvulsive therapy (ECT) is an effective intervention for treatment-resistant depression (TRD). Although prior studies have identified cerebellar functional alterations following ECT, cerebellar-cerebral functional connectivity (FC) changes remain insufficiently explored. Methods: Cerebellar seeds were defined based on prior connectivity studies, targeting cerebellar regions functionally coupled with executive, default-mode, and affective-limbic networks. Seed-based cerebellar-cerebral FC analyses were conducted using neuroimaging data from 72 patients with TRD (52 of whom completed post-ECT assessment) and 63 healthy controls (HCs). Correlation analyses assessed clinical associations, and support vector regression was applied to predict treatment response using baseline FC. Neuroimaging-transcriptomic association analyses were conducted to identify gene expression patterns correlated with post-ECT FC alterations. Results: Compared to HCs, patients with TRD exhibited decreased cerebellar connectivity with the sensorimotor network (SMN) and the default-mode network (DMN). Following ECT, TRD patients showed significant alleviation of depressive symptoms, which was accompanied by a marked increase in cerebellar-DMN connectivity. Enhanced FCs between the left Crus II Conclusions: TRD is associated with reduced cerebellar-SMN and cerebellar-DMN connectivity. ECT may enhance cerebellar-DMN connectivity, potentially contributing to antidepressant effects. (© 2026 The Author(s). Psychiatry and Clinical Neurosciences © 2026 Japanese Society of Psychiatry and Neurology.) |
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| Grant Information: | 82171508 National Natural Science Foundation of China; 2025JJ60706 Natural Science Foundation of Hunan Province |
| Contributed Indexing: | Keywords: cerebellum; functional connectivity; neuroimaging–transcription association analysis; the default‐mode network; treatment‐resistant depression |
| Entry Date(s): | Date Created: 20260508 Date Completed: 20260806 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13447124 |
| DOI: | 10.1111/pcn.70071 |
| PMID: | 42099010 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1440-1819 |
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| DOI: | 10.1111/pcn.70071 |