Academic Journal
Ultrasound-assisted degradation of polysaccharides from sweet corn cob can regulate gut microbiota and activate multiple pathways via the gut-liver axis to alleviate T2DM in mice.
| Τίτλος: | Ultrasound-assisted degradation of polysaccharides from sweet corn cob can regulate gut microbiota and activate multiple pathways via the gut-liver axis to alleviate T2DM in mice. |
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| Συγγραφείς: | Xiu W; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China., Wang X; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China., Yu S; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China., Na Z; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China., Li C; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China., Wang J; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China., Ma Y; College of Food Engineering, Harbin University of Commerce, Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources, Harbin, China. |
| Πηγή: | Journal of the science of food and agriculture [J Sci Food Agric] 2026 Aug 30; Vol. 106 (11), pp. 6555-6569. Date of Electronic Publication: 2026 May 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons Original Publication: London, Society of Chemical Industry. |
| Ιατρικοί όροι (MeSH): | Polysaccharides*/chemistry , Polysaccharides*/administration & dosage , Polysaccharides*/isolation & purification , Polysaccharides*/metabolism , Gastrointestinal Microbiome*/drug effects , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/microbiology , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/genetics , Liver*/metabolism , Liver*/drug effects , Zea mays*/chemistry , Plant Extracts*/administration & dosage , Plant Extracts*/chemistry, Oxidative Stress/drug effects ; Blood Glucose/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Bacteria/isolation & purification ; Bacteria/classification ; Bacteria/genetics ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Animals ; Mice ; Male ; Humans ; Mice, Inbred C57BL ; Signal Transduction |
| Περίληψη: | Background: The prevalence of type 2 diabetes mellitus (T2DM) has been rising in recent years, prompting interest in natural plant polysaccharides for their ability to mitigate the disease. To enhance its bioactivity, a degraded polysaccharide from sweet corn cob with ultrasonic-assisted enzymatic method (UE-DSCCP-A) was prepared, and its structure was also characterized. Furthermore, the significant alleviation effect of UE-DSCCP-A on T2DM has been explored and examined. Results: The results showed that UE-DSCCP-A was primarily composed of glucose, and with a molecular weight of 12.87 kDa. In vivo experiments showed that fasting blood glucose levels in T2DM mice was effectively reduced by UE-DSCCP-A. Additionally, hepatic glucose metabolism could also be regulated by UE-DSCCP-A through phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression. T2DM-induced hepatic oxidative stress injury and inflammatory responses could also be regulated by UE-DSCCP-A through the Nrf2/HO-1 and TLR4/MyD88/NF-κB pathways. Moreover, the gut microbiota in T2DM mice was positively influenced, with an increase in beneficial bacteria such as Lactobacillus, Faecalibaculum, Lachnospiraceae_NK4A136_group, Rikenellaceae_RC9_gut_group, and Alistipes, and a decrease in Romboutsia, Desulfovibrio, and Corynebacterium_1. Conclusion: This study provided evidence that UE-DSCCP-A can regulate T2DM-induced liver damage and gut microbiota imbalances through the gut-liver axis, and the findings may act as a reference for the application of UE-DSCCP-A in functional food. © 2026 Society of Chemical Industry. (© 2026 Society of Chemical Industry.) |
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| Grant Information: | The research was financially supported by the Doctoral Scientific Research Start-up Foundation of the Harbin University of Commerce (Grant No. 2019DS098) and the Industrialization Project from the Harbin University of Commerce (Grant No. 22CZ16) |
| Contributed Indexing: | Keywords: T2DM; gut microbiota; inflammatory response; oxidative stress; polysaccharide; structural characterization |
| Substance Nomenclature: | 0 (Polysaccharides) 0 (Blood Glucose) 0 (NF-kappa B) 0 (Plant Extracts) 0 (Toll-Like Receptor 4) 0 (Myeloid Differentiation Factor 88) 0 (NF-E2-Related Factor 2) |
| Entry Date(s): | Date Created: 20260508 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1002/jsfa.70696 |
| PMID: | 42098935 |
| Βάση Δεδομένων: | MEDLINE |
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