Academic Journal
Effective treatment of scabetic nodules with thalidomide: a 5-year retrospective case series.
| Τίτλος: | Effective treatment of scabetic nodules with thalidomide: a 5-year retrospective case series. |
|---|---|
| Συγγραφείς: | Dong RJ; Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China., Lu YW; Yunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center, Kunming, 650032, China., Cao LJ; Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China., Li Q; Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China., Kuang YQ; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. yq610433@hotmail.com., Li YY; Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. yyeli2000@126.com. |
| Πηγή: | BMC infectious diseases [BMC Infect Dis] 2026 May 07; Vol. 26 (1). Date of Electronic Publication: 2026 May 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Ιατρικοί όροι (MeSH): | Thalidomide*/therapeutic use , Thalidomide*/administration & dosage , Thalidomide*/adverse effects , Scabies*/drug therapy , Scabies*/pathology, Pruritus/drug therapy ; Humans ; Male ; Retrospective Studies ; Adult ; Young Adult ; Adolescent ; Treatment Outcome ; Animals |
| Περίληψη: | Background: Scabetic nodules are a cutaneous hypersensitivity reaction to scabies mites and their byproducts, often accompanied by persistent pruritus. These nodules remain a therapeutic challenge due to the lack of effective treatments. Objective: We sought to assess the effectiveness and tolerance of thalidomide for genital scabetic nodules. Methods: We performed a retrospective evaluation of thalidomide treatment (50-200 mg/day for 2-3 consecutive weeks) in 38 male patients with genital nodular scabies who had previously been infested with scabies mites and were left with persistent pruritic nodules on the genitals. Results: A total of 38 male patients (age range: 18-40 years; mean age: 28.2 ± 5.79 years) with post scabetic nodules were included. Some of them had been refractory to other forms of therapy. Of the 38 patients, 28 patients (73.7%) showed nodule resolution after 2 weeks of treatment. A significant reduction in the number of nodules was observed at the end of the three-week treatment period (P < 0.05), and there was no sign of relapsing. Meanwhile, after two weeks of thalidomide treatment, the patient's pruritus symptoms significantly improved, manifested as a significant decrease in VAS (P < 0.05), and after three weeks of treatment, VAS further significantly decreased (P < 0.05). Infrequent adverse events, including rash, mild dizziness, and/or drowsiness, occurred in nine patients and resolved after drug withdrawal. Conclusion: Thalidomide may be a promising option for treating refractory scabies nodules. Clinical Trial: Not applicable. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: The study involving a human participant was reviewed and approved by the Ethics committee of the First Affiliated Hospital of Kunming Medical University (approval No. 2018 L-45) and in accordance with the Declaration of Helsinki. The patient provided written informed consent to participate in this study. Written informed consent was obtained from the individual for the publication of any potentially identifiable images or data included in this article. Consent for publication: Written informed consent for publication of the clinical details and/or clinical images was obtained from the patient. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 21xjz33R the Talent Introduction Project of Hubei Polytechnic University; 21xjz34R the Talent Introduction Project of Hubei Polytechnic University; 82203934 the National Natural Science Foundation of China; 82272356 the National Natural Science Foundation of China; 2025535Q01 the Talent Project of First Affiliated Hospital of Kunming Medical University; 2024YNLCYXZX0027 Yunnan Provincial Clinical Medical Center; 202403AC100011 the Key research and development program of Yunnan Province |
| Contributed Indexing: | Keywords: Pruritus; Scabetic nodules; Scabies mites; Thalidomide |
| Substance Nomenclature: | 4Z8R6ORS6L (Thalidomide) |
| Entry Date(s): | Date Created: 20260507 Date Completed: 20260726 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13404918 |
| DOI: | 10.1186/s12879-026-13149-1 |
| PMID: | 42098634 |
| Βάση Δεδομένων: | MEDLINE |
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