Academic Journal
Aetiological factors in functional seizures and functional motor symptoms: shared and distinct features.
| Τίτλος: | Aetiological factors in functional seizures and functional motor symptoms: shared and distinct features. |
|---|---|
| Συγγραφείς: | Millman LSM; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Bhuma S; South London and Maudsley NHS Foundation Trust, London, UK., Basamh Y; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Uloyok-Job J; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Davies J; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Blunstone L; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Manoharan A; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Coebergh JA; Neurology, St George's University Hospitals NHS Foundation Trust, London, England, UK., David AS; Institute of Mental Health, Division of Psychiatry, University College London, London, UK., Edwards MJ; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK., Goldstein LH; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Hodsoll J; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Mehta MA; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK., Nicholson TR; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK., Stanton B; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; King's College Hospital NHS Foundation Trust, London, UK., Winston JS; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; King's College Hospital NHS Foundation Trust, London, UK., Chalder T; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK., Hotopf M; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; South London and Maudsley NHS Foundation Trust, London, UK., Pick S; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK susannah.pick@kcl.ac.uk. |
| Πηγή: | Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2026 Jul 15; Vol. 97 (8), pp. 718-729. Date of Electronic Publication: 2026 Jul 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-330X (Electronic) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : BMJ Publishing Group Original Publication: London : British Medical Association |
| Ιατρικοί όροι (MeSH): | Seizures*/etiology , Seizures*/physiopathology , Seizures*/psychology , Conversion Disorder*/etiology , Conversion Disorder*/physiopathology , Affective Symptoms*, Humans ; Female ; Adult ; Male ; Quality of Life ; Middle Aged ; Young Adult ; Dissociative Disorders |
| Περίληψη: | Background: Functional seizures (FS) and functional motor symptoms (FMS), subtypes of functional neurological disorder, may involve shared and distinct predisposing, precipitating, perpetuating and triggering (PPPT) factors. This study investigated potential self-reported PPPT factors in FS and FMS separately. Methods: 200 participants (FS=50, FMS=50, individuals with anxiety and/or depression (clinical controls [CC]=50, healthy controls [HC]=50) completed an in-depth medical history interview and online questionnaires to assess potential aetiological factors including traumatic/adverse life events, alexithymia, autistic traits, psychological and physical symptoms, illness perceptions, cognitive-behavioural responses and outcome measures of general functioning and health-related quality of life (HRQoL). Results: Participants with FS more frequently reported traumatic/adverse events and psychopathology (eg, dissociation, posttraumatic stress disorder) as possible illness causes/precipitating factors and sensory symptom triggers, relative to FMS and/or CCs. In contrast, participants with FMS endorsed physical illness causes/precipitating factors and physical activity and emotion-related symptom triggers more frequently than FS and/or CCs. Physical and dissociative symptoms were elevated, alongside reductions in HRQoL and general functioning in FS/FMS compared with CCs/HCs. Greater current, threatening illness-related beliefs/cognitions were disclosed in FS/FMS compared with CCs. Negative associations between HRQoL, cognitive-behavioural responses and traumatic/adverse events were also seen in FS/FMS. Conclusions: Traumatic events and psychopathology may be more prominently involved in the development/maintenance of FS and physical illness/injury, physical functioning and alexithymia may be more central to FMS. Unhelpful illness-related beliefs and impacts on HRQoL and general functioning are shared between these subtypes. The results of this study provide insight into potential unique and overlapping characteristics of FS/FMS, with implications for treatment. (© Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group.) |
| Competing Interests: | Competing interests: None declared. |
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| Contributed Indexing: | Keywords: FUNCTIONAL NEUROLOGICAL DISORDER; NEUROPSYCHIATRY; PSYCHIATRY; QUALITY OF LIFE |
| Entry Date(s): | Date Created: 20260507 Date Completed: 20260716 Latest Revision: 20260819 |
| Update Code: | 20260819 |
| PubMed Central ID: | PMC13479279 |
| DOI: | 10.1136/jnnp-2025-337694 |
| PMID: | 42097873 |
| Βάση Δεδομένων: | MEDLINE |
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