Academic Journal
Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults.
| Τίτλος: | Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults. |
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| Συγγραφείς: | Liu C; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Sosnowski DW; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Nyhuis CC; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Johns Hopkins Center on Aging and Health, Baltimore, Maryland., Rabinowitz JA; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey., Eaton WW; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Callow DD; Department of Psychiatry and Behavioral Sciences, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland., Munro CA; Department of Psychiatry and Behavioral Sciences, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland., Walker KA; Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Weng NP; Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Ferrucci L; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland., Spira AP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Johns Hopkins Center on Aging and Health, Baltimore, Maryland.; Department of Psychiatry and Behavioral Sciences, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland., Maher BS; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. |
| Πηγή: | JAMA network open [JAMA Netw Open] 2026 May 01; Vol. 9 (5), pp. e2611474. Date of Electronic Publication: 2026 May 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Chicago, IL : American Medical Association, [2018]- |
| Ιατρικοί όροι (MeSH): | Circadian Rhythm*/physiology , Circadian Rhythm*/genetics , Aging*/genetics , Aging*/physiology , Rest*/physiology , Epigenesis, Genetic*, Humans ; Female ; Cross-Sectional Studies ; Male ; Actigraphy ; Aged ; Middle Aged ; Baltimore ; DNA Methylation |
| Περίληψη: | Importance: Circadian rest-activity rhythms (RARs) are increasingly viewed as aging-relevant behavioral phenotypes, but links to DNA methylation-based epigenetic age acceleration (EAA) are not well defined. Objective: To evaluate associations between multidimensional actigraphy-derived 24-hour RAR metrics (strength and robustness, regularity and fragmentation, and timing) and EAA across 4 epigenetic clocks. Design, Setting, and Participants: This cross-sectional study used data from the Baltimore Epidemiologic Catchment Area Study, wave 5 (2017-2022). The cohort included community-dwelling adults in eastern Baltimore, Maryland, with 7-day wrist actigraphy and blood DNA methylation data. Analyses were conducted from January to December 2025. Exposures: Seven-day wrist actigraphy-derived parametric and nonparametric RAR metrics, including rhythm strength and robustness (amplitude, mesor, relative amplitude, and mean activity during the least active continuous 5-hour period [L5] and most active continuous 10-hour period [M10]), regularity and fragmentation (interdaily stability [IS] and intradaily variability [IV]), timing (acrophase, L5 and M10 start times, and rest and sleep midpoints), and day-to-day timing variability (rest midpoint variability [RMV] and sleep midpoint variability [SMV]). Main Outcomes and Measures: Associations between EAA for 4 clocks (Horvath, Hannum, PhenoAge, and GrimAge) and each RAR metric, evaluated using linear regression models. Results: A total of 207 participants were included (mean [SD] age, 68.42 [7.48] years; 135 [65.2%] female). In fully adjusted models, each 1-SD increase in amplitude, relative amplitude, and IS was associated with lower GrimAge acceleration (amplitude: β, -0.67 [95% CI, -1.24 to -0.09]; P = .02; relative amplitude: β, -0.77 [95% CI, -1.31 to -0.23]; P = .005; IS: β, -0.65 [95% CI, -1.20 to -0.09]; P = .02). Each 1-SD increase in amplitude and IS was also associated with lower PhenoAge acceleration (amplitude: β, -1.20 [95% CI, -2.26 to -0.15]; P = .03; IS: -1.35 [95% CI, -2.36 to -0.34]; P = .009). Higher L5 activity and IV were associated with higher GrimAge acceleration (L5: β, 0.60 [95% CI, 0.06-1.13]; P = .03; IV: β, 0.72 [95% CI, 0.17-1.28]; P = .01). There were nonsignificant but directionally consistent outcomes for the Horvath and Hannum clocks. RAR-EAA effect sizes were generally larger in women than in men (amplitude, mesor, M10, RMV, and SMV; P < .05 for interaction) and in White participants compared with those in other race and ethnicity categories (mesor, IV, and M10; P < .05 for interaction); associations for rhythm-timing metrics varied with age; and Shapley additive explanations analyses identified IS, RMV, and amplitude as 3 of the most influential RAR factors in epigenetic age acceleration. Conclusions and Relevance: In this exploratory cross-sectional study, higher strength and stability of circadian RARs were associated with lower acceleration of epigenetic age (particularly GrimAge and PhenoAge), whereas greater irregularity and more variable activity timing were associated with greater acceleration, supporting the interpretation of RARs as markers of biological aging. |
| Entry Date(s): | Date Created: 20260507 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260716 |
| PubMed Central ID: | PMC13153996 |
| DOI: | 10.1001/jamanetworkopen.2026.11474 |
| PMID: | 42096199 |
| Βάση Δεδομένων: | MEDLINE |
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