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Abnormalities in brain white matter structural networks associated with language function of post-stroke aphasia.

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Τίτλος: Abnormalities in brain white matter structural networks associated with language function of post-stroke aphasia.
Συγγραφείς: Yang X; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China., Chen X; Department of Rehabilitation, The First Affiliated Hospital of Jinan University, Guangzhou, China. binhu1985@126.com., Zheng S; Institute of Applied Psychology, Minnan Normal university, Zhangzhou, 363000, China.; Fujian Key Laboratory of Applied Cognition and Personality, Zhangzhou, 363000, China., Chen L; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China., Zhang M; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China., Yuan H; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China., Chen Z; Department of Rehabilitation, The First Affiliated Hospital of Jinan University, Guangzhou, China. czmxy2020@163.com., Huang R; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China. ruiwang.huang@gmail.com.
Πηγή: Brain imaging and behavior [Brain Imaging Behav] 2026 May 07; Vol. 20 (3). Date of Electronic Publication: 2026 May 07.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE
Imprint Name(s): Original Publication: Secaucus, NJ : Springer
Ιατρικοί όροι (MeSH): Aphasia*/diagnostic imaging , Aphasia*/etiology , Aphasia*/physiopathology , Aphasia*/pathology , Stroke*/complications , Stroke*/diagnostic imaging , Stroke*/physiopathology , White Matter*/diagnostic imaging , White Matter*/pathology , White Matter*/physiopathology , Brain*/diagnostic imaging , Brain*/pathology , Brain*/physiopathology , Language*, Diffusion Tensor Imaging/methods ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology ; Neural Pathways/pathology ; Humans ; Male ; Female ; Middle Aged ; Aged ; Brain Mapping
Περίληψη: Previous studies have found that the pathology of post-stroke aphasia might be related to abnormalities in the white matter connectivity. However, it is still unclear about the neural mechanism of white matter impairment in the post-stroke aphasia. The present study attempted to detect the alteration of the brain white matter structural network in the post-stroke aphasia. We recruited 16 PSA patients who suffered from post-stroke aphasia and 14 healthy controls and acquired their diffusion-tensor imaging data. We performed a deterministic white matter fiber tracking to construct white matter structural network and estimated network topological properties by using graph theory. We also assessed the between-group differences in these parameters and estimated the correlations between the abnormal parameters and clinical assessments in the patients. The patients showed higher shortest path length, higher normalized clustering coefficient, and lower global efficiency than the controls. We found abnormal nodal parameters in the frontal, parietal, basal ganglia, and limbic regions in the patient group. From the rich-club analysis, we found that the patient group showed higher rich-club connections and lower feeder connections than the control group, and had a new rich-club region, the right fusiform gyrus. In summary, this study detected the abnormal both nodal and global parameters of the brain white matter structural network in the post-stroke aphasia. These findings may provide insights into understanding the abnormal brain network and impairment of language function in the post-stroke aphasia.
(© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests.
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Grant Information: 2020YFC2005700 National Key R&D Program of China; A2021113 Provincial Health Commission of Guangdong Province of China; 82171914 National Natural Science Foundation of China; 2018YFC1705006 National Key Research and Development Program of China
Contributed Indexing: Keywords: Diffusion-tensor imaging; Graph theory; Post-stroke aphasia; Rich-club; Structural connectivity
Entry Date(s): Date Created: 20260507 Date Completed: 20260716 Latest Revision: 20260720
Update Code: 20260720
DOI: 10.1007/s11682-026-01111-3
PMID: 42096142
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  Group: Ti
  Data: Abnormalities in brain white matter structural networks associated with language function of post-stroke aphasia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Rehabilitation, The First Affiliated Hospital of Jinan University, Guangzhou, China. binhu1985@126.com.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Institute of Applied Psychology, Minnan Normal university, Zhangzhou, 363000, China.; Fujian Key Laboratory of Applied Cognition and Personality, Zhangzhou, 363000, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Rehabilitation, The First Affiliated Hospital of Jinan University, Guangzhou, China. czmxy2020@163.com.<br /><searchLink fieldCode="AU" term="%22Huang+R%22">Huang R</searchLink>; Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, People's Republic of China. ruiwang.huang@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101300405%22">Brain imaging and behavior</searchLink> [Brain Imaging Behav] 2026 May 07; Vol. 20 (3). <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: English
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101300405 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1931-7565 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219317557%22">19317557 </searchLink><i>NLM ISO Abbreviation: </i>Brain Imaging Behav <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Secaucus, NJ : Springer
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  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Aphasia%22">Aphasia*</searchLink>/<searchLink fieldCode="MM" term="%22Aphasia+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Aphasia%22">Aphasia*</searchLink>/<searchLink fieldCode="MM" term="%22Aphasia+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Aphasia%22">Aphasia*</searchLink>/<searchLink fieldCode="MM" term="%22Aphasia+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Aphasia%22">Aphasia*</searchLink>/<searchLink fieldCode="MM" term="%22Aphasia+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Stroke%22">Stroke*</searchLink>/<searchLink fieldCode="MM" term="%22Stroke+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Stroke%22">Stroke*</searchLink>/<searchLink fieldCode="MM" term="%22Stroke+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Stroke%22">Stroke*</searchLink>/<searchLink fieldCode="MM" term="%22Stroke+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22White+Matter%22">White Matter*</searchLink>/<searchLink fieldCode="MM" term="%22White+Matter+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22White+Matter%22">White Matter*</searchLink>/<searchLink fieldCode="MM" term="%22White+Matter+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22White+Matter%22">White Matter*</searchLink>/<searchLink fieldCode="MM" term="%22White+Matter+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Language%22">Language*</searchLink><br /><searchLink fieldCode="MH" term="%22Diffusion+Tensor+Imaging%22">Diffusion Tensor Imaging</searchLink>/<searchLink fieldCode="MH" term="%22Diffusion+Tensor+Imaging+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Neural+Pathways%22">Neural Pathways</searchLink>/<searchLink fieldCode="MH" term="%22Neural+Pathways+diagnostic+imaging%22">diagnostic imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Neural+Pathways%22">Neural Pathways</searchLink>/<searchLink fieldCode="MH" term="%22Neural+Pathways+physiopathology%22">physiopathology</searchLink> ; <searchLink fieldCode="MH" term="%22Neural+Pathways%22">Neural Pathways</searchLink>/<searchLink fieldCode="MH" term="%22Neural+Pathways+pathology%22">pathology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Brain+Mapping%22">Brain Mapping</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Previous studies have found that the pathology of post-stroke aphasia might be related to abnormalities in the white matter connectivity. However, it is still unclear about the neural mechanism of white matter impairment in the post-stroke aphasia. The present study attempted to detect the alteration of the brain white matter structural network in the post-stroke aphasia. We recruited 16 PSA patients who suffered from post-stroke aphasia and 14 healthy controls and acquired their diffusion-tensor imaging data. We performed a deterministic white matter fiber tracking to construct white matter structural network and estimated network topological properties by using graph theory. We also assessed the between-group differences in these parameters and estimated the correlations between the abnormal parameters and clinical assessments in the patients. The patients showed higher shortest path length, higher normalized clustering coefficient, and lower global efficiency than the controls. We found abnormal nodal parameters in the frontal, parietal, basal ganglia, and limbic regions in the patient group. From the rich-club analysis, we found that the patient group showed higher rich-club connections and lower feeder connections than the control group, and had a new rich-club region, the right fusiform gyrus. In summary, this study detected the abnormal both nodal and global parameters of the brain white matter structural network in the post-stroke aphasia. These findings may provide insights into understanding the abnormal brain network and impairment of language function in the post-stroke aphasia.<br /> (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
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  Data: 2020YFC2005700 National Key R&D Program of China; A2021113 Provincial Health Commission of Guangdong Province of China; 82171914 National Natural Science Foundation of China; 2018YFC1705006 National Key Research and Development Program of China
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  Data: <i>Keywords: </i>Diffusion-tensor imaging; Graph theory; Post-stroke aphasia; Rich-club; Structural connectivity
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  Data: <i>Date Created: </i>20260507 <i>Date Completed: </i>20260716 <i>Latest Revision: </i>20260720
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      – TitleFull: Abnormalities in brain white matter structural networks associated with language function of post-stroke aphasia.
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              Text: 2026 May 07
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              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1931-7565
          Numbering:
            – Type: volume
              Value: 20
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Brain imaging and behavior
              Type: main
ResultId 1