Academic Journal
Efficacy and safety of transcranial direct current stimulation in alcohol use disorder: A randomized controlled triple-blind trial.
| Τίτλος: | Efficacy and safety of transcranial direct current stimulation in alcohol use disorder: A randomized controlled triple-blind trial. |
|---|---|
| Συγγραφείς: | Trojak B; Service Hospitalo-Universitaire d'Addictologie, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France.; INSERM U1093, UFR STAPS, Université Bourgogne Europe, Dijon, France., Sauvaget A; Mouvement, Interactions, Performance, MIP, UR 4334, Nantes Université, CHU Nantes, Nantes, France., El Hage W; CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France.; UMR 1253, iBrain, Université de Tours, INSERM, Tours, France., Wallenhorst T; Service de Psychiatrie Adultes et Addictologie, CH Semur-en-Auxois, Semur-en-Auxois, France., Rolland B; Service Universitaire d'Addictologie de Lyon (SUAL), Hospices Civils de Lyon, CH Le Vinatier, Lyon France unité PSR2, CRNL, UMR 5292 CNRS/1028 INSERM - Université Lyon 1, Bron, France., Nubukpo P; Inserm U1094, IRD UMR270, Université de Limoges, CHU Limoges, EpiMaCT, Limoges, France.; Pôle universitaire de de psychiatrie adultes et addictologie (PUP3A), Centre Hospitalier Esquirol, Limoges, France., Harika-Germaneau G; CeRCA, CNRS, Université de Poitiers, Université de Tours, Poitiers, France.; Unité de Recherche Clinique Pierre Deniker du Centre Hospitalier Henri Laborit, Poitiers, France., Szekely D; Service de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco., Giustiniani J; UMR INSERM 1322 LINC, Université de Franche Comté, Besançon, France., Auriacombe M; SANPSY, CNRS UMR 6033, Université de Bordeaux, Bordeaux, France.; Pôle Inter-Établissement d'Addictologie, CHU Bordeaux et CH Charles Perrens, Bordeaux, France., Brousse G; Service de Psychiatrie Adulte et d'Addictologie, CHU Clermont-Ferrand CNRS, Université Clermont-Auvergne, Institut Pascal, Clermont-Ferrand, France., Guillaume S; Service Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHRU, Montpellier, France., Bubrovszky M; Fédération Régionale de Recherche en Santé Mentale et Psychiatrie, Hauts-de-France, France.; Etablissement Public de Santé Mentale de l'Agglomération Lilloise, St André-lez-Lille, France., Petit B; Service Hospitalo-Universitaire d'Addictologie, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France., Cabelguen C; Addiction Medicine and Psychiatry Department, Nantes Université, CHU Nantes, Nantes, France., El Ayoubi H; CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France., Rankin S; Direction de la Recherche Clinique et de l'Innovation, Unité de Soutien Méthodologique à la Recherche, CHU Dijon Bourgogne, Dijon, France., Soudry-Faure A; Direction de la Recherche Clinique et de l'Innovation, Unité de Soutien Méthodologique à la Recherche, CHU Dijon Bourgogne, Dijon, France., Goueslard K; Direction de la Recherche Clinique et de l'Innovation, Unité de Soutien Méthodologique à la Recherche, CHU Dijon Bourgogne, Dijon, France., Demina A; Service Hospitalo-Universitaire d'Addictologie, Université Bourgogne Europe, CHU Dijon Bourgogne, Dijon, France.; INSERM U1093, UFR STAPS, Université Bourgogne Europe, Dijon, France. |
| Πηγή: | Addiction (Abingdon, England) [Addiction] 2026 Aug; Vol. 121 (8), pp. 2141-2153. Date of Electronic Publication: 2026 May 06. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9304118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1360-0443 (Electronic) Linking ISSN: 09652140 NLM ISO Abbreviation: Addiction Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Wiley-Blackwell Original Publication: Abingdon, Oxfordshire, UK : Carfax Pub. Co., c1993- |
| Ιατρικοί όροι (MeSH): | Transcranial Direct Current Stimulation*/methods , Transcranial Direct Current Stimulation*/adverse effects , Alcoholism*/therapy, Humans ; Male ; Middle Aged ; Female ; Treatment Outcome ; Adult ; France ; Craving |
| Περίληψη: | Background and Aims: Current treatment options for alcohol use disorder are limited. Transcranial direct current stimulation has been proposed as a therapeutic approach, but evidence remains scarce. This study aimed to compare active vs. sham transcranial direct current stimulation to evaluate its efficacy and safety in reducing alcohol consumption in a large sample of individuals with alcohol use disorder. Design: REDSTIM is a triple-blind, randomized, sham-controlled trial that was conducted from October 2015 to January 2022. Participants were followed up every 4 weeks for 24 weeks. Setting: Fourteen sites in France and Monaco. Participants: 356 adult outpatients with alcohol use disorder were assessed for eligibility, and 337 were enrolled and randomly assigned (1:1) to receive active or sham stimulation. At baseline, the randomized participants were primarily male (60.5%) with an average age of 51.3 ± 11.3 years. Intervention and Comparator: Two daily stimulation sessions (anode F4, cathode F3, 2 mA) delivered over five consecutive days vs. sham stimulation. Direct currents were applied via a pair of 0.9% NaCl-soaked surface sponge electrodes (25 cm2). In the sham stimulation group, the initial ramp-up time of 15 s (also up to 2 mA) was immediately followed by a ramp down phase of 30 seconds. Measurements: The co-primary outcomes were the change in the number of heavy drinking days (HDD) and total alcohol consumption (TAC) over the follow-up period. Exploratory secondary outcomes included alcohol craving, clinical and biological improvements, quality-of-life, mood, cognitive and safety assessments. Findings: Over 24 weeks of follow-up, vs. sham, the active stimulation group reported statistically significant reductions in the number of HDD [-2.45 HDD/4 weeks, 97.5% confidence interval (CI) = -4.86 to -0.05, P = 0.022]. The reduction in TAC was not statistically significant (-5.96 g/day, 97.5% CI = -15.18 to 3.26, P = 0.147). The interpretation of these findings should take into account the proportion of missing data related to alcohol diary completeness and losses to follow-up. For secondary outcomes at 24 weeks, vs. sham, craving assessments were lower in the stimulation group (-0.36 95% CI = -0.65 to -0.07, P = 0.016), as were carbohydrate deficient transferrin levels (-0.33 95% CI = -0.65 to -0.01, P = 0.045). In the active vs. sham stimulation group, 69 (41.1%) and 62 participants (36.7%) experienced one or more adverse effects, resulting in 6 dropouts. Conclusions: Among adult outpatients with alcohol use disorder, active transcranial direct current stimulation resulted in a modest but sustained reduction in heavy drinking days over 24 weeks, while no statistically significant effect was observed for total alcohol consumption. The intervention was well tolerated. (© 2026 The Author(s). Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.) |
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| Grant Information: | PHRC 2015-A00576-43 French Ministry of Health; 06-2015 Scientific Center of Monaco |
| Contributed Indexing: | Keywords: alcohol use disorder; efficacy; heavy drinking days; randomized controlled trial; safety; total alcohol consumption; transcranial direct current stimulation |
| Entry Date(s): | Date Created: 20260506 Date Completed: 20260712 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13357871 |
| DOI: | 10.1111/add.70461 |
| PMID: | 42091052 |
| Βάση Δεδομένων: | MEDLINE |
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