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Response of the DUF630 gene family in soybean to drought stress: A comprehensive expression analysis.

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Title: Response of the DUF630 gene family in soybean to drought stress: A comprehensive expression analysis.
Authors: Zaynab M; Institute of Biological Sciences, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan. Electronic address: madiha.zaynab14@gmail.com., Sharif Y; College of Plant Protection, Fujian Agriculture and Forestry University, Fujian, China., Khan J; Institute of Chemistry, Khwaja Fareed University of Engineering and Information Technology Rahim Yar Khan, Pakistan., Al-Yahyai R; Department of Plant Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, PO Box 34, Al-Khod 123, Muscat, Oman., Sadder M; School of Agriculture, University of Jordan, Amman 11942, Jordan., Mohamed RAEH; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Source: Computational biology and chemistry [Comput Biol Chem] 2026 Oct; Vol. 124 (Pt 1), pp. 109078. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE
Imprint Name(s): Publication: Oxford : Elsevier
Original Publication: Oxford : Pergamon, c2003-
MeSH Terms: Glycine max*/genetics , Stress, Physiological*/genetics , Plant Proteins*/genetics , Droughts* , Gene Expression Regulation, Plant*, Multigene Family ; Gene Expression Profiling ; Phylogeny ; Drought Resistance
Abstract: The domain of unknown function 630 (DUF630) protein family play a significant role in plant development and abiotic stress responses. However, their exact roles in soybean have not been thoroughly investigated. This study provides a comprehensive analysis of the GmDUF630 gene family, which was categorized into four distinct phylogenetic groups. Gene expression profiling revealed distinct patterns, with a strong stress response exhibited by a GmDUF630 gene cluster. Notably, GmDUF630-31 showed a 9-fold increase under drought stress. Gene promoter analysis revealed cis-regulatory elements associated with developmental processes and abiotic stress response. Tissue-specific expression was also observed. Furthermore, GmDUF630-3 was expressed at a 7-fold higher level expression in leaves, while GmDUF630-13 and GmDUF630-10 were expressed at a 15-fold and 20-fold higher level in roots and stems, respectively. These results strongly indicate that the GmDUF630 gene family is crucial for soybean adaptation to environmental stresses, making it a valuable source of candidate genes for developing stress-resilient soybean varieties.
(Copyright © 2026 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Comments: Erratum in: Comput Biol Chem. 2026 Oct;124(Pt 1):109121. doi: 10.1016/j.compbiolchem.2026.109121.. (PMID: 42108119)
Contributed Indexing: Keywords: Abiotic stress; DUF630; Gene expression; Salinity stress; Soybean; Transcriptome analysis
Substance Nomenclature: 0 (Plant Proteins)
Entry Date(s): Date Created: 20260505 Date Completed: 20260618 Latest Revision: 20260618
Update Code: 20260619
DOI: 10.1016/j.compbiolchem.2026.109078
PMID: 42085833
Database: MEDLINE
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  Data: Response of the DUF630 gene family in soybean to drought stress: A comprehensive expression analysis.
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  Data: <searchLink fieldCode="AU" term="%22Zaynab+M%22">Zaynab M</searchLink>; Institute of Biological Sciences, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan. Electronic address: madiha.zaynab14@gmail.com.<br /><searchLink fieldCode="AU" term="%22Sharif+Y%22">Sharif Y</searchLink>; College of Plant Protection, Fujian Agriculture and Forestry University, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Khan+J%22">Khan J</searchLink>; Institute of Chemistry, Khwaja Fareed University of Engineering and Information Technology Rahim Yar Khan, Pakistan.<br /><searchLink fieldCode="AU" term="%22Al-Yahyai+R%22">Al-Yahyai R</searchLink>; Department of Plant Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, PO Box 34, Al-Khod 123, Muscat, Oman.<br /><searchLink fieldCode="AU" term="%22Sadder+M%22">Sadder M</searchLink>; School of Agriculture, University of Jordan, Amman 11942, Jordan.<br /><searchLink fieldCode="AU" term="%22Mohamed+RAEH%22">Mohamed RAEH</searchLink>; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
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  Data: <searchLink fieldCode="JN" term="%22101157394%22">Computational biology and chemistry</searchLink> [Comput Biol Chem] 2026 Oct; Vol. 124 (Pt 1), pp. 109078. <i>Date of Electronic Publication: </i>2026 Apr 23.
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  Data: <searchLink fieldCode="MM" term="%22Glycine+max%22">Glycine max*</searchLink>/<searchLink fieldCode="MM" term="%22Glycine+max+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Stress%2C+Physiological%22">Stress, Physiological*</searchLink>/<searchLink fieldCode="MM" term="%22Stress%2C+Physiological+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Proteins%22">Plant Proteins*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Proteins+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Droughts%22">Droughts*</searchLink> <br /><searchLink fieldCode="MM" term="%22Gene+Expression+Regulation%2C+Plant%22">Gene Expression Regulation, Plant*</searchLink><br /><searchLink fieldCode="MH" term="%22Multigene+Family%22">Multigene Family</searchLink> ; <searchLink fieldCode="MH" term="%22Gene+Expression+Profiling%22">Gene Expression Profiling</searchLink> ; <searchLink fieldCode="MH" term="%22Phylogeny%22">Phylogeny</searchLink> ; <searchLink fieldCode="MH" term="%22Drought+Resistance%22">Drought Resistance</searchLink>
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  Data: The domain of unknown function 630 (DUF630) protein family play a significant role in plant development and abiotic stress responses. However, their exact roles in soybean have not been thoroughly investigated. This study provides a comprehensive analysis of the GmDUF630 gene family, which was categorized into four distinct phylogenetic groups. Gene expression profiling revealed distinct patterns, with a strong stress response exhibited by a GmDUF630 gene cluster. Notably, GmDUF630-31 showed a 9-fold increase under drought stress. Gene promoter analysis revealed cis-regulatory elements associated with developmental processes and abiotic stress response. Tissue-specific expression was also observed. Furthermore, GmDUF630-3 was expressed at a 7-fold higher level expression in leaves, while GmDUF630-13 and GmDUF630-10 were expressed at a 15-fold and 20-fold higher level in roots and stems, respectively. These results strongly indicate that the GmDUF630 gene family is crucial for soybean adaptation to environmental stresses, making it a valuable source of candidate genes for developing stress-resilient soybean varieties.<br /> (Copyright © 2026 Elsevier Ltd. All rights reserved.)
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  Data: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: Erratum in: Comput Biol Chem. 2026 Oct;124(Pt 1):109121. doi: 10.1016/j.compbiolchem.2026.109121.. (PMID: <searchLink fieldCode="PM" term="%2242108119%22">42108119)</searchLink>
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  Data: <i>Keywords: </i>Abiotic stress; DUF630; Gene expression; Salinity stress; Soybean; Transcriptome analysis
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