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Visualizing nanoplastic-metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Visualizing nanoplastic-metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe.
Συγγραφείς: Wei S; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhang L; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China., Tan J; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu S; College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China., Arabi M; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn., Ostovan A; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn., Zhuang X; College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China., Chen L; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Πηγή: The Analyst [Analyst] 2026 Jun 02; Vol. 151 (11), pp. 3291-3297. Date of Electronic Publication: 2026 Jun 02.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 0372652 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-5528 (Electronic) Linking ISSN: 00032654 NLM ISO Abbreviation: Analyst Subsets: MEDLINE
Imprint Name(s): Publication: Cambridge : Royal Society of Chemistry
Original Publication: London : Chemical Society
Ιατρικοί όροι (MeSH): Fluorescent Dyes*/chemistry , Fluorescent Dyes*/toxicity , Fluorescent Dyes*/chemical synthesis , Sulfhydryl Compounds*/analysis , Sulfhydryl Compounds*/chemistry , Mercury*/chemistry , Mercury*/toxicity , Glutathione*/analysis, Oxidative Stress/drug effects ; Polymethyl Methacrylate/chemistry ; Polymethyl Methacrylate/toxicity ; Naphthalimides/chemistry ; Naphthalimides/toxicity ; Naphthalimides/radiation effects ; Naphthalimides/chemical synthesis ; Cysteine/analysis ; Zebrafish ; Animals ; Fluorescent Chemosensor Compounds ; Humans ; HeLa Cells ; Limit of Detection ; Infrared Rays
Περίληψη: Visualizing the combined toxic effects of micro(nano)plastics and heavy metal ions remains challenging due to the lack of suitable in situ imaging tools, and current co-exposure models are often simplified by simple mixing rather than using pre-formed complexes. In this work, a near-infrared biothiol fluorescent probe was developed based on a naphthalimide scaffold with an α,β-unsaturated acetyl group as a recognition site. The probe exhibits high sensitivity and selectivity toward biothiols, and the detection limit was determined to be 0.47 μM for Cys, 0.37 μM for GSH, and 0.95 μM for Hcy, respectively. This enables the monitoring of biothiol fluctuations in living cells and zebrafish. Using pre-formed PMMA-Hg2+ complexes as co-exposure pollutant models, we investigated nanoplastic-metal ion complex induced oxidative stress in living cells and zebrafish. Imaging results revealed that PMMA-Hg2+ complex co-exposure induces distinct biothiol fluctuation patterns compared to single exposure of PMMA or Hg2+. The surface charge alterations of complexes and lysosomal function were found to be involved in the process. This study provides visual evidence for elucidating the combined toxicity mechanisms of nanoplastic-heavy metal complex co-exposure.
Substance Nomenclature: 0 (Fluorescent Dyes)
0 (Fluorescent Chemosensor Compounds)
0 (Sulfhydryl Compounds)
FXS1BY2PGL (Mercury)
GAN16C9B8O (Glutathione)
9011-14-7 (Polymethyl Methacrylate)
0 (Naphthalimides)
K848JZ4886 (Cysteine)
Entry Date(s): Date Created: 20260505 Date Completed: 20260616 Latest Revision: 20260616
Update Code: 20260616
DOI: 10.1039/d6an00278a
PMID: 42084039
Βάση Δεδομένων: MEDLINE
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Header DbId: cmedm
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An: 42084039
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PubType: Academic Journal
PubTypeId: academicJournal
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IllustrationInfo
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  Group: Ti
  Data: Visualizing nanoplastic-metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wei+S%22">Wei S</searchLink>; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China.<br /><searchLink fieldCode="AU" term="%22Arabi+M%22">Arabi M</searchLink>; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.<br /><searchLink fieldCode="AU" term="%22Ostovan+A%22">Ostovan A</searchLink>; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zhuang+X%22">Zhuang X</searchLink>; College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
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  Data: <searchLink fieldCode="JN" term="%220372652%22">The Analyst</searchLink> [Analyst] 2026 Jun 02; Vol. 151 (11), pp. 3291-3297. <i>Date of Electronic Publication: </i>2026 Jun 02.
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  Data: English
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0372652 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1364-5528 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200032654%22">00032654 </searchLink><i>NLM ISO Abbreviation: </i>Analyst <i>Subsets: </i>MEDLINE
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  Label: Imprint Name(s)
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  Data: <i>Publication</i>: Cambridge : Royal Society of Chemistry<br /><i>Original Publication</i>: London : Chemical Society
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  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Fluorescent+Dyes%22">Fluorescent Dyes*</searchLink>/<searchLink fieldCode="MM" term="%22Fluorescent+Dyes+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Fluorescent+Dyes%22">Fluorescent Dyes*</searchLink>/<searchLink fieldCode="MM" term="%22Fluorescent+Dyes+toxicity%22">toxicity</searchLink> <br /><searchLink fieldCode="MM" term="%22Fluorescent+Dyes%22">Fluorescent Dyes*</searchLink>/<searchLink fieldCode="MM" term="%22Fluorescent+Dyes+chemical+synthesis%22">chemical synthesis</searchLink> <br /><searchLink fieldCode="MM" term="%22Sulfhydryl+Compounds%22">Sulfhydryl Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Sulfhydryl+Compounds+analysis%22">analysis</searchLink> <br /><searchLink fieldCode="MM" term="%22Sulfhydryl+Compounds%22">Sulfhydryl Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Sulfhydryl+Compounds+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Mercury%22">Mercury*</searchLink>/<searchLink fieldCode="MM" term="%22Mercury+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Mercury%22">Mercury*</searchLink>/<searchLink fieldCode="MM" term="%22Mercury+toxicity%22">toxicity</searchLink> <br /><searchLink fieldCode="MM" term="%22Glutathione%22">Glutathione*</searchLink>/<searchLink fieldCode="MM" term="%22Glutathione+analysis%22">analysis</searchLink><br /><searchLink fieldCode="MH" term="%22Oxidative+Stress%22">Oxidative Stress</searchLink>/<searchLink fieldCode="MH" term="%22Oxidative+Stress+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Polymethyl+Methacrylate%22">Polymethyl Methacrylate</searchLink>/<searchLink fieldCode="MH" term="%22Polymethyl+Methacrylate+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Polymethyl+Methacrylate%22">Polymethyl Methacrylate</searchLink>/<searchLink fieldCode="MH" term="%22Polymethyl+Methacrylate+toxicity%22">toxicity</searchLink> ; <searchLink fieldCode="MH" term="%22Naphthalimides%22">Naphthalimides</searchLink>/<searchLink fieldCode="MH" term="%22Naphthalimides+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Naphthalimides%22">Naphthalimides</searchLink>/<searchLink fieldCode="MH" term="%22Naphthalimides+toxicity%22">toxicity</searchLink> ; <searchLink fieldCode="MH" term="%22Naphthalimides%22">Naphthalimides</searchLink>/<searchLink fieldCode="MH" term="%22Naphthalimides+radiation+effects%22">radiation effects</searchLink> ; <searchLink fieldCode="MH" term="%22Naphthalimides%22">Naphthalimides</searchLink>/<searchLink fieldCode="MH" term="%22Naphthalimides+chemical+synthesis%22">chemical synthesis</searchLink> ; <searchLink fieldCode="MH" term="%22Cysteine%22">Cysteine</searchLink>/<searchLink fieldCode="MH" term="%22Cysteine+analysis%22">analysis</searchLink> ; <searchLink fieldCode="MH" term="%22Zebrafish%22">Zebrafish</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Fluorescent+Chemosensor+Compounds%22">Fluorescent Chemosensor Compounds</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22HeLa+Cells%22">HeLa Cells</searchLink> ; <searchLink fieldCode="MH" term="%22Limit+of+Detection%22">Limit of Detection</searchLink> ; <searchLink fieldCode="MH" term="%22Infrared+Rays%22">Infrared Rays</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Visualizing the combined toxic effects of micro(nano)plastics and heavy metal ions remains challenging due to the lack of suitable in situ imaging tools, and current co-exposure models are often simplified by simple mixing rather than using pre-formed complexes. In this work, a near-infrared biothiol fluorescent probe was developed based on a naphthalimide scaffold with an α,β-unsaturated acetyl group as a recognition site. The probe exhibits high sensitivity and selectivity toward biothiols, and the detection limit was determined to be 0.47 μM for Cys, 0.37 μM for GSH, and 0.95 μM for Hcy, respectively. This enables the monitoring of biothiol fluctuations in living cells and zebrafish. Using pre-formed PMMA-Hg<superscript>2+</superscript> complexes as co-exposure pollutant models, we investigated nanoplastic-metal ion complex induced oxidative stress in living cells and zebrafish. Imaging results revealed that PMMA-Hg<superscript>2+</superscript> complex co-exposure induces distinct biothiol fluctuation patterns compared to single exposure of PMMA or Hg<superscript>2+</superscript>. The surface charge alterations of complexes and lysosomal function were found to be involved in the process. This study provides visual evidence for elucidating the combined toxicity mechanisms of nanoplastic-heavy metal complex co-exposure.
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Fluorescent Dyes)<br />0 (Fluorescent Chemosensor Compounds)<br />0 (Sulfhydryl Compounds)<br />FXS1BY2PGL (Mercury)<br />GAN16C9B8O (Glutathione)<br />9011-14-7 (Polymethyl Methacrylate)<br />0 (Naphthalimides)<br />K848JZ4886 (Cysteine)
– Name: DateEntry
  Label: Entry Date(s)
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  Data: <i>Date Created: </i>20260505 <i>Date Completed: </i>20260616 <i>Latest Revision: </i>20260616
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  Data: 20260616
– Name: DOI
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  Data: 10.1039/d6an00278a
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  Data: 42084039
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42084039
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        Value: 10.1039/d6an00278a
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 3291
    Subjects:
      – SubjectFull: Oxidative Stress drug effects
        Type: general
      – SubjectFull: Polymethyl Methacrylate chemistry
        Type: general
      – SubjectFull: Polymethyl Methacrylate toxicity
        Type: general
      – SubjectFull: Naphthalimides chemistry
        Type: general
      – SubjectFull: Naphthalimides toxicity
        Type: general
      – SubjectFull: Naphthalimides radiation effects
        Type: general
      – SubjectFull: Naphthalimides chemical synthesis
        Type: general
      – SubjectFull: Cysteine analysis
        Type: general
      – SubjectFull: Zebrafish
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Fluorescent Chemosensor Compounds
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: HeLa Cells
        Type: general
      – SubjectFull: Limit of Detection
        Type: general
      – SubjectFull: Infrared Rays
        Type: general
      – SubjectFull: Fluorescent Dyes chemistry
        Type: general
      – SubjectFull: Fluorescent Dyes toxicity
        Type: general
      – SubjectFull: Fluorescent Dyes chemical synthesis
        Type: general
      – SubjectFull: Sulfhydryl Compounds analysis
        Type: general
      – SubjectFull: Sulfhydryl Compounds chemistry
        Type: general
      – SubjectFull: Mercury chemistry
        Type: general
      – SubjectFull: Mercury toxicity
        Type: general
      – SubjectFull: Glutathione analysis
        Type: general
    Titles:
      – TitleFull: Visualizing nanoplastic-metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe.
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            – D: 02
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              Text: 2026 Jun 02
              Type: published
              Y: 2026
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