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Clinical value and safety of liver biopsy in patients with liver failure.

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Title: Clinical value and safety of liver biopsy in patients with liver failure.
Authors: Jiao J; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China.; Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, 100069, China., Zhao R; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China., Zhang Y; People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, 830001, China., Xu M; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China. xmm1903@ccmu.edu.cn.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China. xmm1903@ccmu.edu.cn., Chen Y; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn.
Source: BMC gastroenterology [BMC Gastroenterol] 2026 May 02; Vol. 26 (1). Date of Electronic Publication: 2026 May 02.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
Imprint Name(s): Original Publication: London : BioMed Central, [2001-
MeSH Terms: Liver*/pathology , Liver Failure*/pathology , Liver Failure*/etiology, Biopsy/methods ; Biopsy/adverse effects ; Acute-On-Chronic Liver Failure/pathology ; Acute-On-Chronic Liver Failure/etiology ; Liver Failure, Acute/pathology ; Liver Failure, Acute/etiology ; Ascites/etiology ; Humans ; Female ; Retrospective Studies ; Male ; Middle Aged ; Adult ; Aged ; International Normalized Ratio ; Platelet Count
Abstract: Background: To evaluate the safety, etiological diagnostic value, and impact on clinical treatment decisions of transjugular liver biopsy (TJLB) and percutaneous liver biopsy (PLB) in patients with liver failure.
Methods: This retrospective study included patients with liver failure who underwent liver biopsy between January 1, 2017, and November 30, 2025. Demographic characteristics, clinical data, post-procedural adverse events, and pathological diagnoses were collected and subjected to statistical analysis.
Results: A total of 53 patients with liver failure were included, comprising 40 patients with acute-on-chronic liver failure (ACLF) and 13 patients with acute or subacute liver failure. 13 patients received TJLB, all of whom had ACLF. Compared with the PLB, patients in the TJLB group had a higher international normalized ratio (INR) [1.61 (1.32, 1.98)], a lower platelet count (PLT) [89.00 (73.00, 129.00) × 10⁹/L], and were more frequently complicated by moderate to large ascites. Both PLB and TJLB were successfully performed, with a low overall complication rate and no serious adverse events. Even among patients with marked coagulation abnormalities or concomitant ascites, TJLB demonstrated acceptable safety. Histopathological examination following liver biopsy enables reclassification of both chronic liver disease etiologies and acute precipitating factors in patients with ACLF, as well as etiological diagnoses in patients with acute liver failure (ALF) or subacute liver failure (SALF). A substantial proportion of drug- or toxin-related acute liver injury was identified by histopathological examination (n = 32, 60%), leading to a decreased proportion of liver failure with unclear etiology. Based on the pathological diagnosis, treatment strategies were modified in 11% of patients, including the initiation or continuation of specific therapeutic regimens.
Conclusions: In patients with liver failure, liver biopsy provides crucial information for determining the etiology and guiding clinical decision-making. With appropriate selection of the biopsy approach and patient population, TJLB can serve as a safe and feasible option, particularly for patients with coagulation disorders or severe ascites.
(© 2026. The Author(s).)
Competing Interests: Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Ethics Committee of Beijing Youan Hospital, Capital Medical University (LL-2015-099-K), with all data anonymized before analysis and the requirement for informed consent waived. Written informed consent was obtained from all patients before liver biopsy as part of routine clinical care and was not related to participation in this study. All procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: This study is retrospective and informed consent is waived for all patients. Competing interests: The authors declare no competing interests.
References: Hepatol Int. 2019 Jul;13(4):353-390. (PMID: 31172417)
Clin Transl Gastroenterol. 2019 Jul;10(7):e00063. (PMID: 31259750)
Sci Rep. 2017 Dec 4;7(1):16878. (PMID: 29203879)
J Multidiscip Healthc. 2024 May 17;17:2399-2407. (PMID: 38779307)
BMC Gastroenterol. 2001;1:12. (PMID: 11707153)
Cureus. 2021 Nov 14;13(11):e19555. (PMID: 34917436)
Radiology. 1984 Oct;153(1):91-3. (PMID: 6473806)
Lancet. 1993 Jul 31;342(8866):273-5. (PMID: 8101303)
Hepatology. 2005 May;41(5):1179-97. (PMID: 15841455)
J Clin Med. 2023 Nov 30;12(23):. (PMID: 38068503)
Diagnostics (Basel). 2021 Jan 16;11(1):. (PMID: 33467069)
BMC Gastroenterol. 2023 Aug 14;23(1):282. (PMID: 37580680)
JHEP Rep. 2024 Jun 10;6(9):101131. (PMID: 39170946)
Gastroenterology. 2023 Oct;165(4):1025-1040. (PMID: 37380136)
Hepatology. 2009 Mar;49(3):1017-44. (PMID: 19243014)
Radiology. 1967 Jan;88(1):35-9. (PMID: 6015615)
Expert Rev Gastroenterol Hepatol. 2022 Jul;16(7):639-652. (PMID: 35786130)
Ann Intensive Care. 2025 Aug 26;15(1):123. (PMID: 40855373)
J Vasc Interv Radiol. 2019 Aug;30(8):1168-1184.e1. (PMID: 31229333)
J Hepatol. 2019 Jun;70(6):1222-1261. (PMID: 30926241)
J Vasc Interv Radiol. 2023 Jan;34(1):1-3. (PMID: 36244632)
Clin Mol Hepatol. 2023 Jul;29(3):670-689. (PMID: 36938601)
J Hepatol. 2007 Aug;47(2):284-94. (PMID: 17561303)
Liver Int. 2025 Mar;45(3):e16097. (PMID: 39254214)
Eur J Radiol. 2020 Dec;133:109399. (PMID: 33202374)
Dig Liver Dis. 2019 Aug;51(8):1144-1151. (PMID: 30862438)
Int J Infect Dis. 2022 Sep;122:476-485. (PMID: 35724827)
Am J Gastroenterol. 2014 Jul;109(7):950-66; quiz 967. (PMID: 24935270)
Hepatology. 2019 May;69(5):2150-2163. (PMID: 30615211)
J Vasc Interv Radiol. 2023 Dec;34(12):2120-2127.e2. (PMID: 37625665)
J Clin Gastroenterol. 2024 Oct 01;58(9):912-916. (PMID: 38047588)
World J Gastroenterol. 2023 Jan 14;29(2):232-240. (PMID: 36687118)
Gut. 2022 Jan;71(1):148-155. (PMID: 33436495)
Expert Rev Gastroenterol Hepatol. 2018 Jun;12(6):565-573. (PMID: 29806950)
Gut. 1995 Mar;36(3):437-41. (PMID: 7698705)
Gut. 2020 Aug;69(8):1382-1403. (PMID: 32467090)
Cardiovasc Intervent Radiol. 2017 Oct;40(10):1501-1513. (PMID: 28523447)
J Hepatol. 2015 Apr;62(1 Suppl):S131-43. (PMID: 25920082)
Contributed Indexing: Keywords: Etiological diagnosis; Hepatitis B virus; Liver failure; Percutaneous liver biopsy; Safety; Transjugular liver biopsy
Entry Date(s): Date Created: 20260502 Date Completed: 20260705 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13335296
DOI: 10.1186/s12876-026-04863-w
PMID: 42069533
Database: MEDLINE
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  Data: Clinical value and safety of liver biopsy in patients with liver failure.
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  Data: <searchLink fieldCode="AU" term="%22Jiao+J%22">Jiao J</searchLink>; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China.; Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, 100069, China.<br /><searchLink fieldCode="AU" term="%22Zhao+R%22">Zhao R</searchLink>; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, 830001, China.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China. xmm1903@ccmu.edu.cn.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China. xmm1903@ccmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100968547%22">BMC gastroenterology</searchLink> [BMC Gastroenterol] 2026 May 02; Vol. 26 (1). <i>Date of Electronic Publication: </i>2026 May 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100968547 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-230X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221471230X%22">1471230X </searchLink><i>NLM ISO Abbreviation: </i>BMC Gastroenterol <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: London : BioMed Central, [2001-
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  Data: <searchLink fieldCode="MM" term="%22Liver%22">Liver*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Liver+Failure%22">Liver Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+Failure+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Liver+Failure%22">Liver Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+Failure+etiology%22">etiology</searchLink><br /><searchLink fieldCode="MH" term="%22Biopsy%22">Biopsy</searchLink>/<searchLink fieldCode="MH" term="%22Biopsy+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Biopsy%22">Biopsy</searchLink>/<searchLink fieldCode="MH" term="%22Biopsy+adverse+effects%22">adverse effects</searchLink> ; <searchLink fieldCode="MH" term="%22Acute-On-Chronic+Liver+Failure%22">Acute-On-Chronic Liver Failure</searchLink>/<searchLink fieldCode="MH" term="%22Acute-On-Chronic+Liver+Failure+pathology%22">pathology</searchLink> ; <searchLink fieldCode="MH" term="%22Acute-On-Chronic+Liver+Failure%22">Acute-On-Chronic Liver Failure</searchLink>/<searchLink fieldCode="MH" term="%22Acute-On-Chronic+Liver+Failure+etiology%22">etiology</searchLink> ; <searchLink fieldCode="MH" term="%22Liver+Failure%2C+Acute%22">Liver Failure, Acute</searchLink>/<searchLink fieldCode="MH" term="%22Liver+Failure%2C+Acute+pathology%22">pathology</searchLink> ; <searchLink fieldCode="MH" term="%22Liver+Failure%2C+Acute%22">Liver Failure, Acute</searchLink>/<searchLink fieldCode="MH" term="%22Liver+Failure%2C+Acute+etiology%22">etiology</searchLink> ; <searchLink fieldCode="MH" term="%22Ascites%22">Ascites</searchLink>/<searchLink fieldCode="MH" term="%22Ascites+etiology%22">etiology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Retrospective+Studies%22">Retrospective Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22International+Normalized+Ratio%22">International Normalized Ratio</searchLink> ; <searchLink fieldCode="MH" term="%22Platelet+Count%22">Platelet Count</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: To evaluate the safety, etiological diagnostic value, and impact on clinical treatment decisions of transjugular liver biopsy (TJLB) and percutaneous liver biopsy (PLB) in patients with liver failure.<br />Methods: This retrospective study included patients with liver failure who underwent liver biopsy between January 1, 2017, and November 30, 2025. Demographic characteristics, clinical data, post-procedural adverse events, and pathological diagnoses were collected and subjected to statistical analysis.<br />Results: A total of 53 patients with liver failure were included, comprising 40 patients with acute-on-chronic liver failure (ACLF) and 13 patients with acute or subacute liver failure. 13 patients received TJLB, all of whom had ACLF. Compared with the PLB, patients in the TJLB group had a higher international normalized ratio (INR) [1.61 (1.32, 1.98)], a lower platelet count (PLT) [89.00 (73.00, 129.00) × 10⁹/L], and were more frequently complicated by moderate to large ascites. Both PLB and TJLB were successfully performed, with a low overall complication rate and no serious adverse events. Even among patients with marked coagulation abnormalities or concomitant ascites, TJLB demonstrated acceptable safety. Histopathological examination following liver biopsy enables reclassification of both chronic liver disease etiologies and acute precipitating factors in patients with ACLF, as well as etiological diagnoses in patients with acute liver failure (ALF) or subacute liver failure (SALF). A substantial proportion of drug- or toxin-related acute liver injury was identified by histopathological examination (n = 32, 60%), leading to a decreased proportion of liver failure with unclear etiology. Based on the pathological diagnosis, treatment strategies were modified in 11% of patients, including the initiation or continuation of specific therapeutic regimens.<br />Conclusions: In patients with liver failure, liver biopsy provides crucial information for determining the etiology and guiding clinical decision-making. With appropriate selection of the biopsy approach and patient population, TJLB can serve as a safe and feasible option, particularly for patients with coagulation disorders or severe ascites.<br /> (© 2026. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Ethics Committee of Beijing Youan Hospital, Capital Medical University (LL-2015-099-K), with all data anonymized before analysis and the requirement for informed consent waived. Written informed consent was obtained from all patients before liver biopsy as part of routine clinical care and was not related to participation in this study. All procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: This study is retrospective and informed consent is waived for all patients. Competing interests: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Hepatol Int. 2019 Jul;13(4):353-390. (PMID: <searchLink fieldCode="PM" term="%2231172417%22">31172417)</searchLink><br />Clin Transl Gastroenterol. 2019 Jul;10(7):e00063. (PMID: <searchLink fieldCode="PM" term="%2231259750%22">31259750)</searchLink><br />Sci Rep. 2017 Dec 4;7(1):16878. (PMID: <searchLink fieldCode="PM" term="%2229203879%22">29203879)</searchLink><br />J Multidiscip Healthc. 2024 May 17;17:2399-2407. (PMID: <searchLink fieldCode="PM" term="%2238779307%22">38779307)</searchLink><br />BMC Gastroenterol. 2001;1:12. (PMID: <searchLink fieldCode="PM" term="%2211707153%22">11707153)</searchLink><br />Cureus. 2021 Nov 14;13(11):e19555. (PMID: <searchLink fieldCode="PM" term="%2234917436%22">34917436)</searchLink><br />Radiology. 1984 Oct;153(1):91-3. (PMID: <searchLink fieldCode="PM" term="%226473806%22">6473806)</searchLink><br />Lancet. 1993 Jul 31;342(8866):273-5. (PMID: <searchLink fieldCode="PM" term="%228101303%22">8101303)</searchLink><br />Hepatology. 2005 May;41(5):1179-97. (PMID: <searchLink fieldCode="PM" term="%2215841455%22">15841455)</searchLink><br />J Clin Med. 2023 Nov 30;12(23):. (PMID: <searchLink fieldCode="PM" term="%2238068503%22">38068503)</searchLink><br />Diagnostics (Basel). 2021 Jan 16;11(1):. (PMID: <searchLink fieldCode="PM" term="%2233467069%22">33467069)</searchLink><br />BMC Gastroenterol. 2023 Aug 14;23(1):282. (PMID: <searchLink fieldCode="PM" term="%2237580680%22">37580680)</searchLink><br />JHEP Rep. 2024 Jun 10;6(9):101131. (PMID: <searchLink fieldCode="PM" term="%2239170946%22">39170946)</searchLink><br />Gastroenterology. 2023 Oct;165(4):1025-1040. (PMID: <searchLink fieldCode="PM" term="%2237380136%22">37380136)</searchLink><br />Hepatology. 2009 Mar;49(3):1017-44. (PMID: <searchLink fieldCode="PM" term="%2219243014%22">19243014)</searchLink><br />Radiology. 1967 Jan;88(1):35-9. (PMID: <searchLink fieldCode="PM" term="%226015615%22">6015615)</searchLink><br />Expert Rev Gastroenterol Hepatol. 2022 Jul;16(7):639-652. (PMID: <searchLink fieldCode="PM" term="%2235786130%22">35786130)</searchLink><br />Ann Intensive Care. 2025 Aug 26;15(1):123. (PMID: <searchLink fieldCode="PM" term="%2240855373%22">40855373)</searchLink><br />J Vasc Interv Radiol. 2019 Aug;30(8):1168-1184.e1. (PMID: <searchLink fieldCode="PM" term="%2231229333%22">31229333)</searchLink><br />J Hepatol. 2019 Jun;70(6):1222-1261. (PMID: <searchLink fieldCode="PM" term="%2230926241%22">30926241)</searchLink><br />J Vasc Interv Radiol. 2023 Jan;34(1):1-3. (PMID: <searchLink fieldCode="PM" term="%2236244632%22">36244632)</searchLink><br />Clin Mol Hepatol. 2023 Jul;29(3):670-689. (PMID: <searchLink fieldCode="PM" term="%2236938601%22">36938601)</searchLink><br />J Hepatol. 2007 Aug;47(2):284-94. (PMID: <searchLink fieldCode="PM" term="%2217561303%22">17561303)</searchLink><br />Liver Int. 2025 Mar;45(3):e16097. (PMID: <searchLink fieldCode="PM" term="%2239254214%22">39254214)</searchLink><br />Eur J Radiol. 2020 Dec;133:109399. (PMID: <searchLink fieldCode="PM" term="%2233202374%22">33202374)</searchLink><br />Dig Liver Dis. 2019 Aug;51(8):1144-1151. (PMID: <searchLink fieldCode="PM" term="%2230862438%22">30862438)</searchLink><br />Int J Infect Dis. 2022 Sep;122:476-485. (PMID: <searchLink fieldCode="PM" term="%2235724827%22">35724827)</searchLink><br />Am J Gastroenterol. 2014 Jul;109(7):950-66; quiz 967. (PMID: <searchLink fieldCode="PM" term="%2224935270%22">24935270)</searchLink><br />Hepatology. 2019 May;69(5):2150-2163. (PMID: <searchLink fieldCode="PM" term="%2230615211%22">30615211)</searchLink><br />J Vasc Interv Radiol. 2023 Dec;34(12):2120-2127.e2. (PMID: <searchLink fieldCode="PM" term="%2237625665%22">37625665)</searchLink><br />J Clin Gastroenterol. 2024 Oct 01;58(9):912-916. (PMID: <searchLink fieldCode="PM" term="%2238047588%22">38047588)</searchLink><br />World J Gastroenterol. 2023 Jan 14;29(2):232-240. (PMID: <searchLink fieldCode="PM" term="%2236687118%22">36687118)</searchLink><br />Gut. 2022 Jan;71(1):148-155. (PMID: <searchLink fieldCode="PM" term="%2233436495%22">33436495)</searchLink><br />Expert Rev Gastroenterol Hepatol. 2018 Jun;12(6):565-573. (PMID: <searchLink fieldCode="PM" term="%2229806950%22">29806950)</searchLink><br />Gut. 1995 Mar;36(3):437-41. (PMID: <searchLink fieldCode="PM" term="%227698705%22">7698705)</searchLink><br />Gut. 2020 Aug;69(8):1382-1403. (PMID: <searchLink fieldCode="PM" term="%2232467090%22">32467090)</searchLink><br />Cardiovasc Intervent Radiol. 2017 Oct;40(10):1501-1513. (PMID: <searchLink fieldCode="PM" term="%2228523447%22">28523447)</searchLink><br />J Hepatol. 2015 Apr;62(1 Suppl):S131-43. (PMID: <searchLink fieldCode="PM" term="%2225920082%22">25920082)</searchLink>
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  Data: <i>Keywords: </i>Etiological diagnosis; Hepatitis B virus; Liver failure; Percutaneous liver biopsy; Safety; Transjugular liver biopsy
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        Text: English
    Subjects:
      – SubjectFull: Biopsy methods
        Type: general
      – SubjectFull: Biopsy adverse effects
        Type: general
      – SubjectFull: Acute-On-Chronic Liver Failure pathology
        Type: general
      – SubjectFull: Acute-On-Chronic Liver Failure etiology
        Type: general
      – SubjectFull: Liver Failure, Acute pathology
        Type: general
      – SubjectFull: Liver Failure, Acute etiology
        Type: general
      – SubjectFull: Ascites etiology
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Retrospective Studies
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      – SubjectFull: Male
        Type: general
      – SubjectFull: Middle Aged
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        Type: general
      – SubjectFull: International Normalized Ratio
        Type: general
      – SubjectFull: Platelet Count
        Type: general
      – SubjectFull: Liver pathology
        Type: general
      – SubjectFull: Liver Failure pathology
        Type: general
      – SubjectFull: Liver Failure etiology
        Type: general
    Titles:
      – TitleFull: Clinical value and safety of liver biopsy in patients with liver failure.
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      – PersonEntity:
          Name:
            NameFull: Zhao R
      – PersonEntity:
          Name:
            NameFull: Zhang Y
      – PersonEntity:
          Name:
            NameFull: Xu M
      – PersonEntity:
          Name:
            NameFull: Chen Y
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 05
              Text: 2026 May 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1471-230X
          Numbering:
            – Type: volume
              Value: 26
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: BMC gastroenterology
              Type: main
ResultId 1