Academic Journal
Clinical value and safety of liver biopsy in patients with liver failure.
| Τίτλος: | Clinical value and safety of liver biopsy in patients with liver failure. |
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| Συγγραφείς: | Jiao J; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China.; Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, 100069, China., Zhao R; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China., Zhang Y; People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, 830001, China., Xu M; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China. xmm1903@ccmu.edu.cn.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China. xmm1903@ccmu.edu.cn., Chen Y; Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing You'an Hospital, Capital Medical University, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn.; Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing, 100069, China. chybeyond1071@ccmu.edu.cn. |
| Πηγή: | BMC gastroenterology [BMC Gastroenterol] 2026 May 02; Vol. 26 (1). Date of Electronic Publication: 2026 May 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| Ιατρικοί όροι (MeSH): | Liver*/pathology , Liver Failure*/pathology , Liver Failure*/etiology, Biopsy/methods ; Biopsy/adverse effects ; Acute-On-Chronic Liver Failure/pathology ; Acute-On-Chronic Liver Failure/etiology ; Liver Failure, Acute/pathology ; Liver Failure, Acute/etiology ; Ascites/etiology ; Humans ; Female ; Retrospective Studies ; Male ; Middle Aged ; Adult ; Aged ; International Normalized Ratio ; Platelet Count |
| Περίληψη: | Background: To evaluate the safety, etiological diagnostic value, and impact on clinical treatment decisions of transjugular liver biopsy (TJLB) and percutaneous liver biopsy (PLB) in patients with liver failure. Methods: This retrospective study included patients with liver failure who underwent liver biopsy between January 1, 2017, and November 30, 2025. Demographic characteristics, clinical data, post-procedural adverse events, and pathological diagnoses were collected and subjected to statistical analysis. Results: A total of 53 patients with liver failure were included, comprising 40 patients with acute-on-chronic liver failure (ACLF) and 13 patients with acute or subacute liver failure. 13 patients received TJLB, all of whom had ACLF. Compared with the PLB, patients in the TJLB group had a higher international normalized ratio (INR) [1.61 (1.32, 1.98)], a lower platelet count (PLT) [89.00 (73.00, 129.00) × 10⁹/L], and were more frequently complicated by moderate to large ascites. Both PLB and TJLB were successfully performed, with a low overall complication rate and no serious adverse events. Even among patients with marked coagulation abnormalities or concomitant ascites, TJLB demonstrated acceptable safety. Histopathological examination following liver biopsy enables reclassification of both chronic liver disease etiologies and acute precipitating factors in patients with ACLF, as well as etiological diagnoses in patients with acute liver failure (ALF) or subacute liver failure (SALF). A substantial proportion of drug- or toxin-related acute liver injury was identified by histopathological examination (n = 32, 60%), leading to a decreased proportion of liver failure with unclear etiology. Based on the pathological diagnosis, treatment strategies were modified in 11% of patients, including the initiation or continuation of specific therapeutic regimens. Conclusions: In patients with liver failure, liver biopsy provides crucial information for determining the etiology and guiding clinical decision-making. With appropriate selection of the biopsy approach and patient population, TJLB can serve as a safe and feasible option, particularly for patients with coagulation disorders or severe ascites. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Ethics Committee of Beijing Youan Hospital, Capital Medical University (LL-2015-099-K), with all data anonymized before analysis and the requirement for informed consent waived. Written informed consent was obtained from all patients before liver biopsy as part of routine clinical care and was not related to participation in this study. All procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: This study is retrospective and informed consent is waived for all patients. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Etiological diagnosis; Hepatitis B virus; Liver failure; Percutaneous liver biopsy; Safety; Transjugular liver biopsy |
| Entry Date(s): | Date Created: 20260502 Date Completed: 20260705 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13335296 |
| DOI: | 10.1186/s12876-026-04863-w |
| PMID: | 42069533 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1471-230X |
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| DOI: | 10.1186/s12876-026-04863-w |