Academic Journal
Sexually dimorphic effects of lipopolysaccharide on spatial memory.
| Τίτλος: | Sexually dimorphic effects of lipopolysaccharide on spatial memory. |
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| Συγγραφείς: | Cloud MB; University of North Carolina Wilmington, Department of Psychology, Wilmington, NC, USA. Electronic address: mbc6403@uncw.edu., Jordan SK; University of North Carolina Wilmington, Department of Psychology, Wilmington, NC, USA. Electronic address: jordans@uncw.edu., Kohman RA; University of North Carolina Wilmington, Department of Psychology, Wilmington, NC, USA. Electronic address: kohmanr@uncw.edu. |
| Πηγή: | Physiology & behavior [Physiol Behav] 2026 Sep 01; Vol. 313, pp. 115355. Date of Electronic Publication: 2026 Apr 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York NY : Elsevier Science Original Publication: Oxford, Eng., Long Island City, Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Lipopolysaccharides*/pharmacology , Lipopolysaccharides*/toxicity , Spatial Memory*/drug effects , Spatial Memory*/physiology , Sex Characteristics*, Hippocampus/drug effects ; Hippocampus/metabolism ; Maze Learning/drug effects ; Cytokines/metabolism ; Spleen/metabolism ; Spleen/drug effects ; Animals ; Female ; Male ; Mice, Inbred C57BL ; Mice |
| Περίληψη: | Deficits in hippocampal-dependent memory tasks following lipopolysaccharide (LPS) administration are frequently reported. However, prior work has predominantly been conducted with males. Given recent reports showing sex-related differences in the cognitive effects of an acute LPS challenge, the present study evaluated whether sex differences in spatial learning and memory exist. Adult female and male C57BL/6 J mice were evaluated for spatial learning and memory in a hidden platform version of the water maze following administration of LPS (0.25 mg/kg) prior to the first day of training. Results showed that LPS impaired spatial memory in males but had no effect on memory in females. Females and males showed differential use of behavioral search strategies during the probe trial, which may contribute to the selective vulnerability seen in males. Assessment of hippocampal and splenic inflammatory markers showed similar LPS-induced expression across the sexes, indicating that cytokine induction does not produce comparable cognitive deficits in males and females. However, males showed higher hippocampal expression of the interleukin type 1 receptor accessory proteins (AcP and AcPb) relative to females that may alter the impact of inflammation on the hippocampus. Ultimately, these data extend recent findings of sex-dependent effects of LPS on cognition to the water maze and emphasize the importance of reporting and comparing subjects' biological sex. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interest None. |
| Contributed Indexing: | Keywords: AcP; AcPb; Cytokine; Female; LPS; Wnt3a |
| Substance Nomenclature: | 0 (Lipopolysaccharides) 0 (Cytokines) |
| Entry Date(s): | Date Created: 20260502 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260716 |
| DOI: | 10.1016/j.physbeh.2026.115355 |
| PMID: | 42069278 |
| Βάση Δεδομένων: | MEDLINE |
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