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The efficacy of cognitive behavioral therapy for persecutory delusions: A systematic review and meta-analysis.

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Τίτλος: The efficacy of cognitive behavioral therapy for persecutory delusions: A systematic review and meta-analysis.
Συγγραφείς: Liu X; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China., Wang H; The First Hospital of Jilin University, Changchun, Jilin, China., Wang S; The First Hospital of Jilin University, Changchun, Jilin, China., Wang R; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China., Zhao Q; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China., Tian S; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China., Guo X; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China., Cao H; The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: chshi1977@163.com.
Πηγή: Psychiatry research [Psychiatry Res] 2026 Aug; Vol. 362, pp. 117188. Date of Electronic Publication: 2026 Apr 22.
Τύπος έκδοσης: Journal Article; Systematic Review; Meta-Analysis
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE
Imprint Name(s): Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
Ιατρικοί όροι (MeSH): Delusions*/therapy , Paranoid Disorders*/therapy , Cognitive Behavioral Therapy* , Outcome Assessment, Health Care*, Humans
Περίληψη: Background: Persecutory delusions, prevalent in disorders like schizophrenia, significantly impair daily functioning and cause distress. Although cognitive behavioral therapy (CBT) has shown promise in treating delusions, no meta-analysis has specifically evaluated its effectiveness for persecutory delusions.
Objectives: To identify studies on CBT specifically designed for patients with persecutory delusions and to evaluate its impact on delusion-related symptoms, including the conviction of persecutory delusions, paranoia severity, and psychological well-being.
Methods: A comprehensive search of 10 electronic databases was conducted until December 4, 2025, to identify randomized controlled trials on CBT for persecutory delusions. Two independent reviewers screened studies, assessed quality, and extracted data.
Results: Ten studies including 904 participants were included. CBT was associated with a small reduction in the conviction of persecutory delusions (SMD = -0.31, 95% CI, -0.45 to -0.18, p < 0.001; moderate-quality evidence), a small reduction in the severity of paranoia (SMD = -0.29, 95% CI: -0.43 to -0.15, p < 0.001; high-quality evidence), and a small improvement in psychological well-being (SMD = 0.36, 95% CI: 0.09 to 0.63, p = 0.01; moderate-quality evidence). Subgroup analyses revealed comparable effect sizes across intervention duration, session frequency, gender composition, and follow-up interval, with no evidence of effect modification.
Conclusions: CBT shows promising efficacy for treating persecutory delusions. Further rigorous trials are required to determine optimal intervention parameters and long-term effects.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Cognitive behavioral therapy; Meta-analysis; Persecutory delusions; Psychological well-being; Systematic review
Entry Date(s): Date Created: 20260501 Date Completed: 20260716 Latest Revision: 20260814
Update Code: 20260814
DOI: 10.1016/j.psychres.2026.117188
PMID: 42066482
Βάση Δεδομένων: MEDLINE
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  Data: The efficacy of cognitive behavioral therapy for persecutory delusions: A systematic review and meta-analysis.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Liu+X%22&quot;&gt;Liu X&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+H%22&quot;&gt;Wang H&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+S%22&quot;&gt;Wang S&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Wang+R%22&quot;&gt;Wang R&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Zhao+Q%22&quot;&gt;Zhao Q&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Tian+S%22&quot;&gt;Tian S&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Guo+X%22&quot;&gt;Guo X&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China; School of Nursing, Jilin University, Changchun, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Cao+H%22&quot;&gt;Cao H&lt;/searchLink&gt;; The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: chshi1977@163.com.
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  Data: Background: Persecutory delusions, prevalent in disorders like schizophrenia, significantly impair daily functioning and cause distress. Although cognitive behavioral therapy (CBT) has shown promise in treating delusions, no meta-analysis has specifically evaluated its effectiveness for persecutory delusions.&lt;br /&gt;Objectives: To identify studies on CBT specifically designed for patients with persecutory delusions and to evaluate its impact on delusion-related symptoms, including the conviction of persecutory delusions, paranoia severity, and psychological well-being.&lt;br /&gt;Methods: A comprehensive search of 10 electronic databases was conducted until December 4, 2025, to identify randomized controlled trials on CBT for persecutory delusions. Two independent reviewers screened studies, assessed quality, and extracted data.&lt;br /&gt;Results: Ten studies including 904 participants were included. CBT was associated with a small reduction in the conviction of persecutory delusions (SMD = -0.31, 95% CI, -0.45 to -0.18, p &amp;lt; 0.001; moderate-quality evidence), a small reduction in the severity of paranoia (SMD = -0.29, 95% CI: -0.43 to -0.15, p &amp;lt; 0.001; high-quality evidence), and a small improvement in psychological well-being (SMD = 0.36, 95% CI: 0.09 to 0.63, p = 0.01; moderate-quality evidence). Subgroup analyses revealed comparable effect sizes across intervention duration, session frequency, gender composition, and follow-up interval, with no evidence of effect modification.&lt;br /&gt;Conclusions: CBT shows promising efficacy for treating persecutory delusions. Further rigorous trials are required to determine optimal intervention parameters and long-term effects.&lt;br /&gt; (Copyright &#169; 2026 Elsevier B.V. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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