Academic Journal
Patterns of presentation of suspected and confirmed recurrent venous thromboembolism in patients with prior venous thromboembolism.
| Τίτλος: | Patterns of presentation of suspected and confirmed recurrent venous thromboembolism in patients with prior venous thromboembolism. |
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| Συγγραφείς: | Mai V; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, Québec, Canada., Martens ESL; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Righini M; Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland., Schulman S; Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada., Thiruganasambandamoorthy V; University of Ottawa, Department of Emergency Medicine, Ottawa, Ontario, Canada., Bates V; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada., Pecarskie A; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada., Kovacs MJ; Division of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada., Visser S; Department of Emergency Medicine, Hôpital Montfort, Ottawa, Ontario, Canada., Shivakumar S; Department of Medicine, Dalhousie University, Nova Scotia Health, Halifax, Nova Scotia, Canada., Tan M; Hospital Gelderse Vallei, Ede, the Netherlands., Rodger M; Department of Medicine, McGill University, McGill University Health Center, Montreal, Québec, Canada., Scarvelis D; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada., Delluc A; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada., Girard P; Département de Pneumologie, Institut Mutualiste Montsouris, Paris, France.; French Clinical Research Infrastructure Network INNOVTE Network, Saint-Etienne, France., Huisman MV; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Wells PS; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada., Klok FA; Department of Medicine-Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Le Gal G; Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada., Kahn SR; Division of Internal Medicine, Department of Medicine, McGill University, Montreal, Québec, Canada. |
| Συλλογικό Έργο: | PREDICTORS study group |
| Πηγή: | Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2026 Mar 25; Vol. 10 (3), pp. 103442. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Multicenter Study; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 101703775 Publication Model: eCollection Cited Medium: Internet ISSN: 2475-0379 (Electronic) Linking ISSN: 24750379 NLM ISO Abbreviation: Res Pract Thromb Haemost Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : [New York] : Elsevier Original Publication: Hoboken, NJ : John Wiley & Sons, Inc., [2017]- |
| Ιατρικοί όροι (MeSH): | Venous Thromboembolism*/diagnosis , Venous Thromboembolism*/epidemiology , Venous Thromboembolism*/pathology, Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology ; Venous Thrombosis/pathology ; Lower Extremity/pathology ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/pathology ; Humans ; Recurrence ; Male ; Female ; Adult ; Middle Aged ; Aged ; Prospective Studies ; Risk Factors |
| Περίληψη: | Background: Patients with prior venous thromboembolism (VTE) seem to recur more frequently at the same site as their prior VTE, but their symptoms at presentation of suspected recurrent VTE is unclear. Objectives: The aim was to describe the patterns of presentation of suspected and confirmed recurrent VTE. Methods: This is a secondary analysis of the PREDICTORS study (ClinicalTrials.gov: NCT02297373), an international prospective multicenter observational cohort study. The primary outcomes were the location of symptoms and confirmed diagnosis of suspected recurrent VTE. Results: In total, 708 patients were included. Patients with isolated deep venous thrombosis (DVT) as the most recent prior VTE presenting with suspected recurrent VTE had more frequently lower extremity symptoms only (249/343; 73%), rather than respiratory symptoms only (41/343; 12%), and confirmed recurrent VTE were mostly isolated proximal DVT (78/100; 78%). Patients with isolated pulmonary embolism as the most recent prior VTE presented more frequently with respiratory symptoms only (136/237; 56%), rather than lower extremity symptoms only (42/237; 18%), and confirmed recurrent VTE were more frequently isolated pulmonary embolism (38/62; 61%). Among patients with DVT as the most recent prior VTE, confirmed recurrent DVT were more frequently in the ipsilateral leg of the index event (ipsilateral 72/468 [15%], contralateral 31/468 [7%]; odds ratio 2.3 [95% CI, 1.5-3.6]). Conclusion: In addition to confirming that patients were more frequently diagnosed with recurrent VTE at the same site of their last VTE, our study reported on suspected recurrent VTE symptoms and showed that patients presented more frequently with symptoms related to the same site of their last VTE. (© 2026 The Authors.) |
| Contributed Indexing: | Investigator: M Carrier; C Code; E Gandara; L Castellucci; M Forgie; C Gonsalves; L Duffett; A Karovitch; T Ramsay; M Blostein; V Tagalakis; A Hirsch; M Koolian; M Louzada; A Lazo-Langner; S Couban; D Anderson; D White; D Macdonald; KS Robinson; W Hasegawa; MM Keating; M Mulligan; M Carrier; K de Wit; L Linkins; A Iorio; J Weitz; C Kearon Keywords: deep venous thrombosis; pulmonary embolism; recurrence; venous thromboembolism |
| Molecular Sequence: | ClinicalTrials.gov NCT02297373 |
| Entry Date(s): | Date Created: 20260430 Date Completed: 20260514 Latest Revision: 20260514 |
| Update Code: | 20260515 |
| PubMed Central ID: | PMC13122812 |
| DOI: | 10.1016/j.rpth.2026.103442 |
| PMID: | 42058833 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2475-0379 |
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| DOI: | 10.1016/j.rpth.2026.103442 |