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[Transitional cognitive syndrome: Reconsidered classification of cognitive disorders].

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Τίτλος: [Transitional cognitive syndrome: Reconsidered classification of cognitive disorders].
Μεταγλωττισμένος Τίτλος: Perekhodnyi kognitivnyi sindrom — novyi vzglyad na klassifikatsiyu kognitivnykh narushenii.
Συγγραφείς: Levin OS; Russian Medical Academy of Continuous Professional Education, Moscow, Russia., Vasenina EE; Russian Medical Academy of Continuous Professional Education, Moscow, Russia.; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia., Gankina OA; Russian Medical Academy of Continuous Professional Education, Moscow, Russia.; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia., Berdalin AB; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia., Morozova IO; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia., Savilov VB; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia., Kurmyshev MV; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia., Andryushchenko AV; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.; M.V. Lomonosov Moscow State University, Moscow, Russia., Kostyuk GP; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.; M.V. Lomonosov Moscow State University, Moscow, Russia.
Πηγή: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2026; Vol. 126 (4. Vyp. 2), pp. 47-55.
Τύπος έκδοσης: English Abstract; Journal Article
Γλώσσα: Russian
Στοιχεία περιοδικού: Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 9712194 Publication Model: Print Cited Medium: Print ISSN: 1997-7298 (Print) Linking ISSN: 19977298 NLM ISO Abbreviation: Zh Nevrol Psikhiatr Im S S Korsakova Subsets: MEDLINE
Imprint Name(s): Publication: <1995->: Moskva : Media Sfera
Original Publication: Moskva : "Meditsina"
Ιατρικοί όροι (MeSH): Cognitive Dysfunction*/classification , Cognitive Dysfunction*/rehabilitation , Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/epidemiology , Dementia*/diagnosis , Dementia*/rehabilitation , Dementia*/classification , Cognition Disorders*/classification, Humans ; Female ; Aged ; Cognitive Training ; Male ; Neuropsychological Tests ; Disease Progression ; Syndrome ; Aged, 80 and over ; Follow-Up Studies
Περίληψη: Objective: To assess the prevalence of the transitional cognitive syndrome (TCS) and evaluate the effectiveness of neurocognitive training in elderly individuals presenting with cognitive symptoms.
Material and Methods: The study enrolled 198 elderly individuals with cognitive impairment symptoms from the Memory Clinics of the Moscow Department of Health and the N.A. Alekseev Psychiatric Clinical Hospital No. 1. Of these, 111 participants were assigned to the intervention group and received neurocognitive training (rehabilitation), while 87 participants formed the comparison group and received follow-up only. Neuropsychological assessments were conducted at baseline and after 12 months of follow-up.
Results: In this sample, TCS accounted for approximately 5% of all cognitive impairments and remained stable over the one-year follow-up period. Annually, about 7% of mild cognitive impairment cases progressed to TCS, while 11-16% of TCS cases advanced to more severe dementia, irrespective of neurorehabilitation. These findings suggest the presence of an active neurodegenerative process. Neurorehabilitation was effective in improving regulatory functions, including among elderly participants.
Conclusion: The introduction of the TCS concept allows for more precise classification of patients at the transitional stage between mild cognitive impairment and dementia. This framework improves risk assessment for short-term progression to more severe cognitive impairment and provides clinical justification for pathogenetic therapy, including the use of Miladean. The TCS concept also supports patient management and reduces the stigma associated with diagnosis at this stage, which is significant for both patients and their families. Advanced age and concomitant diabetes mellitus were identified as the most significant adverse factors for cognitive impairment. The observed effectiveness of neurocognitive rehabilitation in patients aged 75 years and older indicates that rehabilitation should not be limited by age.
Contributed Indexing: Keywords: cognitive impairment; mild cognitive impairment; progression; rehabilitation; transitional cognitive syndrome
Local Abstract: [Publisher, Russian] Определить частоту выявления переходного когнитивного синдрома (ПКС) и эффективность проведения нейрокогнитивного тренинга у пациентов пожилого возраста с когнитивными жалобами. [Publisher, Russian] В исследование включено 198 пациентов пожилого возраста с жалобами на когнитивные нарушения из Клиник памяти ДЗМ и ПКБ №1 ДЗМ им. Н.А. Алексеева, из них 111 вошли в основную группу, которой выполнялся нейрокогнитивный тренинг (реабилитация), 87 — в группу сравнения, за которой проводилось только динамическое наблюдение. Всем участникам было проведено нейропсихологическое тестирование на этапе включения в исследование и через 12 мес наблюдения. [Publisher, Russian] В исследованной выборке доля ПКС составила ~5% от всех когнитивных нарушений и оставалась относительно стабильной в течение года наблюдения. Ежегодно ~7% случаев умеренных когнитивных нарушений переходят в ПКС, а 11—16% случаев ПКС прогрессируют в более тяжелую деменцию, независимо от проводимой нейрореабилитации, что указывает на наличие активно текущего нейродегенеративного процесса. Наиболее неблагоприятными факторами для усугубления когнитивных расстройств (КР) оказались возраст и наличие сахарного диабета. Нейрореабилитация показала себя эффективной для улучшения регуляторных функций, в том числе у пациентов пожилого возраста. [Publisher, Russian] Введение понятия ПКС позволяет точнее выявлять пациентов на критической стадии между умеренным КР и деменцией, что улучшает определение риска перехода когнитивных нарушений в более тяжелые проявления в ближайшее время и создает клинически обоснованную возможность для назначения патогенетической терапии, в том числе препаратом Миладеан. Использование понятия ПКС позволит не только облегчить ведение пациентов с возможностью назначения лекарственных препаратов, но и минимизирует стигматизацию от диагноза на данной стадии КР, что важно как для пациента, так и для его родственников. Доказанная эффективность нейрокогнитивной реабилитации у пациентов старческого возраста (более 75 лет) позволяет не ограничивать возможность проведения реабилитации строго указанным возрастным диапазоном.
Entry Date(s): Date Created: 20260429 Date Completed: 20260716 Latest Revision: 20260716
Update Code: 20260716
DOI: 10.17116/jnevro202612604247
PMID: 42054331
Βάση Δεδομένων: MEDLINE
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  Data: [Transitional cognitive syndrome: Reconsidered classification of cognitive disorders].
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  Data: Perekhodnyi kognitivnyi sindrom — novyi vzglyad na klassifikatsiyu kognitivnykh narushenii.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Levin+OS%22&quot;&gt;Levin OS&lt;/searchLink&gt;; Russian Medical Academy of Continuous Professional Education, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Vasenina+EE%22&quot;&gt;Vasenina EE&lt;/searchLink&gt;; Russian Medical Academy of Continuous Professional Education, Moscow, Russia.; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Gankina+OA%22&quot;&gt;Gankina OA&lt;/searchLink&gt;; Russian Medical Academy of Continuous Professional Education, Moscow, Russia.; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Berdalin+AB%22&quot;&gt;Berdalin AB&lt;/searchLink&gt;; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Morozova+IO%22&quot;&gt;Morozova IO&lt;/searchLink&gt;; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Savilov+VB%22&quot;&gt;Savilov VB&lt;/searchLink&gt;; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Kurmyshev+MV%22&quot;&gt;Kurmyshev MV&lt;/searchLink&gt;; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Andryushchenko+AV%22&quot;&gt;Andryushchenko AV&lt;/searchLink&gt;; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.; M.V. Lomonosov Moscow State University, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Kostyuk+GP%22&quot;&gt;Kostyuk GP&lt;/searchLink&gt;; Moscow City Clinical Psychiatric Hospital No. 1, Moscow, Russia.; M.V. Lomonosov Moscow State University, Moscow, Russia.
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction%22&quot;&gt;Cognitive Dysfunction*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction+classification%22&quot;&gt;classification&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction%22&quot;&gt;Cognitive Dysfunction*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction+rehabilitation%22&quot;&gt;rehabilitation&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction%22&quot;&gt;Cognitive Dysfunction*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction%22&quot;&gt;Cognitive Dysfunction*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognitive+Dysfunction+epidemiology%22&quot;&gt;epidemiology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dementia%22&quot;&gt;Dementia*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dementia+diagnosis%22&quot;&gt;diagnosis&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dementia%22&quot;&gt;Dementia*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dementia+rehabilitation%22&quot;&gt;rehabilitation&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dementia%22&quot;&gt;Dementia*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dementia+classification%22&quot;&gt;classification&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognition+Disorders%22&quot;&gt;Cognition Disorders*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Cognition+Disorders+classification%22&quot;&gt;classification&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%22&quot;&gt;Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cognitive+Training%22&quot;&gt;Cognitive Training&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Neuropsychological+Tests%22&quot;&gt;Neuropsychological Tests&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Disease+Progression%22&quot;&gt;Disease Progression&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Syndrome%22&quot;&gt;Syndrome&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%2C+80+and+over%22&quot;&gt;Aged, 80 and over&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Follow-Up+Studies%22&quot;&gt;Follow-Up Studies&lt;/searchLink&gt;
– Name: Abstract
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  Data: Objective: To assess the prevalence of the transitional cognitive syndrome (TCS) and evaluate the effectiveness of neurocognitive training in elderly individuals presenting with cognitive symptoms.&lt;br /&gt;Material and Methods: The study enrolled 198 elderly individuals with cognitive impairment symptoms from the Memory Clinics of the Moscow Department of Health and the N.A. Alekseev Psychiatric Clinical Hospital No. 1. Of these, 111 participants were assigned to the intervention group and received neurocognitive training (rehabilitation), while 87 participants formed the comparison group and received follow-up only. Neuropsychological assessments were conducted at baseline and after 12 months of follow-up.&lt;br /&gt;Results: In this sample, TCS accounted for approximately 5% of all cognitive impairments and remained stable over the one-year follow-up period. Annually, about 7% of mild cognitive impairment cases progressed to TCS, while 11-16% of TCS cases advanced to more severe dementia, irrespective of neurorehabilitation. These findings suggest the presence of an active neurodegenerative process. Neurorehabilitation was effective in improving regulatory functions, including among elderly participants.&lt;br /&gt;Conclusion: The introduction of the TCS concept allows for more precise classification of patients at the transitional stage between mild cognitive impairment and dementia. This framework improves risk assessment for short-term progression to more severe cognitive impairment and provides clinical justification for pathogenetic therapy, including the use of Miladean. The TCS concept also supports patient management and reduces the stigma associated with diagnosis at this stage, which is significant for both patients and their families. Advanced age and concomitant diabetes mellitus were identified as the most significant adverse factors for cognitive impairment. The observed effectiveness of neurocognitive rehabilitation in patients aged 75 years and older indicates that rehabilitation should not be limited by age.
– Name: SubjectMinor
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  Data: &lt;i&gt;Keywords: &lt;/i&gt;cognitive impairment; mild cognitive impairment; progression; rehabilitation; transitional cognitive syndrome&lt;br /&gt;&lt;i&gt;Local Abstract: &lt;/i&gt;[Publisher, Russian] Определить частоту выявления переходного когнитивного синдрома (ПКС) и эффективность проведения нейрокогнитивного тренинга у пациентов пожилого возраста с когнитивными жалобами. [Publisher, Russian] В исследование включено 198 пациентов пожилого возраста с жалобами на когнитивные нарушения из Клиник памяти ДЗМ и ПКБ №1 ДЗМ им. Н.А. Алексеева, из них 111 вошли в основную группу, которой выполнялся нейрокогнитивный тренинг (реабилитация), 87 — в группу сравнения, за которой проводилось только динамическое наблюдение. Всем участникам было проведено нейропсихологическое тестирование на этапе включения в исследование и через 12 мес наблюдения. [Publisher, Russian] В исследованной выборке доля ПКС составила ~5% от всех когнитивных нарушений и оставалась относительно стабильной в течение года наблюдения. Ежегодно ~7% случаев умеренных когнитивных нарушений переходят в ПКС, а 11—16% случаев ПКС прогрессируют в более тяжелую деменцию, независимо от проводимой нейрореабилитации, что указывает на наличие активно текущего нейродегенеративного процесса. Наиболее неблагоприятными факторами для усугубления когнитивных расстройств (КР) оказались возраст и наличие сахарного диабета. Нейрореабилитация показала себя эффективной для улучшения регуляторных функций, в том числе у пациентов пожилого возраста. [Publisher, Russian] Введение понятия ПКС позволяет точнее выявлять пациентов на критической стадии между умеренным КР и деменцией, что улучшает определение риска перехода когнитивных нарушений в более тяжелые проявления в ближайшее время и создает клинически обоснованную возможность для назначения патогенетической терапии, в том числе препаратом Миладеан. Использование понятия ПКС позволит не только облегчить ведение пациентов с возможностью назначения лекарственных препаратов, но и минимизирует стигматизацию от диагноза на данной стадии КР, что важно как для пациента, так и для его родственников. Доказанная эффективность нейрокогнитивной реабилитации у пациентов старческого возраста (более 75 лет) позволяет не ограничивать возможность проведения реабилитации строго указанным возрастным диапазоном.
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        StartPage: 47
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        Type: general
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              Value: 4. Vyp. 2
          Titles:
            – TitleFull: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
              Type: main
ResultId 1