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Effects of auditory pathway maturation on hearing loss diagnosis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effects of auditory pathway maturation on hearing loss diagnosis.
Συγγραφείς: Savioli S; Surgery Department, San Bortolo Hospital, Vicenza, Italy. sabrina.savioli@uniroma1.it.; Clinical and Experimental Neuroscience and Psychiatry Ph.D. program, University Sapienza of Rome, Rome, Italy. sabrina.savioli@uniroma1.it., Mancini P; Clinical and Experimental Neuroscience and Psychiatry Ph.D. program, University Sapienza of Rome, Rome, Italy.; Department of Sense Organs, University Sapienza of Rome, Rome, Italy., De Seta D; Department of Sense Organs, University Sapienza of Rome, Rome, Italy., Turchetta R; Department of Sense Organs, University Sapienza of Rome, Rome, Italy., Frisina A; Surgery Department, San Bortolo Hospital, Vicenza, Italy., Russo FY; Department of Sense Organs, University Sapienza of Rome, Rome, Italy.
Πηγή: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2026 Jul; Vol. 283 (7), pp. 4357-4364. Date of Electronic Publication: 2026 Apr 29.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: Germany NLM ID: 9002937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-4726 (Electronic) Linking ISSN: 09374477 NLM ISO Abbreviation: Eur Arch Otorhinolaryngol Subsets: MEDLINE
Imprint Name(s): Original Publication: Heidelberg : Springer International, c1990-
Ιατρικοί όροι (MeSH): Evoked Potentials, Auditory, Brain Stem*/physiology , Auditory Pathways*/growth & development , Auditory Pathways*/physiopathology , Hearing Loss*/diagnosis , Hearing Loss*/physiopathology, Neonatal Screening/methods ; Humans ; Infant, Newborn ; Female ; Acoustic Impedance Tests ; Male ; Gestational Age ; Infant, Premature ; Auditory Acuity
Περίληψη: Purpose: The maturation of auditory pathways in newborns, particularly in pre-terms, is a crucial process influencing the accuracy and timeliness of early audiological diagnosis. The aim of this study was to investigate the effect of postnatal auditory pathway maturation on hearing loss diagnosis by comparing early and later ABR assessments in pre-term and full-term newborns.
Methods: Seventy-eight newborns (156 ears) were enrolled and divided by gestational age. All underwent initial screening, clinical Auditory Brainstem Response (ABR), tympanometry, and evaluation of diagnostic timing. Statistical analyses were performed with Jamovi (v.2.3.28).
Results: In full-term newborns, the initial screening significantly predicted ABR outcomes, whereas no such correlation emerged in pre-terms. However, pre-terms showed a significant improvement in ABR thresholds over time, consistent with postnatal maturational effects on auditory pathway function. Additionally, pathological tympanograms (type B) were associated with a delayed diagnosis.
Conclusions: These findings stress the need for tailored protocols and extended follow-up in pre-term newborns, as well as early detection of middle ear conditions to minimize both under- and over-diagnosis.
(© 2026. The Author(s).)
Competing Interests: Declarations. Ethics approval: The study was conducted in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments, and with the current legislation in Italy. Ethical approval was waived by the local Ethics Committee due to the retrospective nature of the study, which utilized previously collected clinical data. Competing interests: The authors declare that they have no competing interests.
References: Acta Otolaryngol Suppl. 2004 Oct;(554):17-25. (PMID: 15513505)
Otolaryngol Head Neck Surg. 2023 Sep;169(3):687-693. (PMID: 36821813)
Wien Klin Wochenschr. 2015 Jun;127(11-12):440-4. (PMID: 25409950)
Codas. 2014 Jul-Aug;26(4):286-93. (PMID: 25211687)
Am J Audiol. 2009 Jun;18(1):24-33. (PMID: 19029532)
Acta Otorhinolaryngol Belg. 2003;57(4):227-36. (PMID: 14714940)
Early Hum Dev. 2013 Jan;89(1):43-8. (PMID: 22849808)
Int J Pediatr Otorhinolaryngol. 2013 Dec;77(12):2030-9. (PMID: 24182601)
Int J Pediatr Otorhinolaryngol. 2007 Sep;71(9):1449-56. (PMID: 17629955)
Br Med Bull. 2002;63:171-81. (PMID: 12324392)
J Matern Fetal Neonatal Med. 2012 Aug;25(8):1342-7. (PMID: 22122007)
Otol Neurotol. 2011 Jul;32(5):799-804. (PMID: 21593700)
Int J Pediatr Otorhinolaryngol. 2011 Feb;75(2):163-70. (PMID: 21129787)
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Aug 20;31(16):1288-1291. (PMID: 29798381)
Dev Med Child Neurol. 2016 Oct;58(10):1009-15. (PMID: 27168415)
Acta Otorhinolaryngol Ital. 2019 Aug;39(4):257-262. (PMID: 31501617)
Int J Pediatr Otorhinolaryngol. 2001 Feb;57(2):137-44. (PMID: 11165651)
J Paediatr Child Health. 2016 Nov;52(11):995-1003. (PMID: 27521761)
Int Arch Otorhinolaryngol. 2017 Jul;21(3):200-205. (PMID: 28680486)
Contributed Indexing: Keywords: Auditory brainstem response; Auditory maturation; Neonatal hearing screening; Otitis media with effusion; Pre-term infants; Tympanometry
Entry Date(s): Date Created: 20260428 Date Completed: 20260721 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13388375
DOI: 10.1007/s00405-026-10205-z
PMID: 42050140
Βάση Δεδομένων: MEDLINE
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  – Url: https://dx.doi.org/doi:10.1007/s00405-026-10205-z
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  Data: Effects of auditory pathway maturation on hearing loss diagnosis.
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  Data: <searchLink fieldCode="AU" term="%22Savioli+S%22">Savioli S</searchLink>; Surgery Department, San Bortolo Hospital, Vicenza, Italy. sabrina.savioli@uniroma1.it.; Clinical and Experimental Neuroscience and Psychiatry Ph.D. program, University Sapienza of Rome, Rome, Italy. sabrina.savioli@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Mancini+P%22">Mancini P</searchLink>; Clinical and Experimental Neuroscience and Psychiatry Ph.D. program, University Sapienza of Rome, Rome, Italy.; Department of Sense Organs, University Sapienza of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Seta+D%22">De Seta D</searchLink>; Department of Sense Organs, University Sapienza of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Turchetta+R%22">Turchetta R</searchLink>; Department of Sense Organs, University Sapienza of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Frisina+A%22">Frisina A</searchLink>; Surgery Department, San Bortolo Hospital, Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+FY%22">Russo FY</searchLink>; Department of Sense Organs, University Sapienza of Rome, Rome, Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9002937 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1434-4726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209374477%22">09374477 </searchLink><i>NLM ISO Abbreviation: </i>Eur Arch Otorhinolaryngol <i>Subsets: </i>MEDLINE
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  Data: Purpose: The maturation of auditory pathways in newborns, particularly in pre-terms, is a crucial process influencing the accuracy and timeliness of early audiological diagnosis. The aim of this study was to investigate the effect of postnatal auditory pathway maturation on hearing loss diagnosis by comparing early and later ABR assessments in pre-term and full-term newborns.<br />Methods: Seventy-eight newborns (156 ears) were enrolled and divided by gestational age. All underwent initial screening, clinical Auditory Brainstem Response (ABR), tympanometry, and evaluation of diagnostic timing. Statistical analyses were performed with Jamovi (v.2.3.28).<br />Results: In full-term newborns, the initial screening significantly predicted ABR outcomes, whereas no such correlation emerged in pre-terms. However, pre-terms showed a significant improvement in ABR thresholds over time, consistent with postnatal maturational effects on auditory pathway function. Additionally, pathological tympanograms (type B) were associated with a delayed diagnosis.<br />Conclusions: These findings stress the need for tailored protocols and extended follow-up in pre-term newborns, as well as early detection of middle ear conditions to minimize both under- and over-diagnosis.<br /> (© 2026. The Author(s).)
– Name: Abstract
  Label: Competing Interests
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  Data: Declarations. Ethics approval: The study was conducted in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments, and with the current legislation in Italy. Ethical approval was waived by the local Ethics Committee due to the retrospective nature of the study, which utilized previously collected clinical data. Competing interests: The authors declare that they have no competing interests.
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  Label: References
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  Data: Acta Otolaryngol Suppl. 2004 Oct;(554):17-25. (PMID: <searchLink fieldCode="PM" term="%2215513505%22">15513505)</searchLink><br />Otolaryngol Head Neck Surg. 2023 Sep;169(3):687-693. (PMID: <searchLink fieldCode="PM" term="%2236821813%22">36821813)</searchLink><br />Wien Klin Wochenschr. 2015 Jun;127(11-12):440-4. (PMID: <searchLink fieldCode="PM" term="%2225409950%22">25409950)</searchLink><br />Codas. 2014 Jul-Aug;26(4):286-93. (PMID: <searchLink fieldCode="PM" term="%2225211687%22">25211687)</searchLink><br />Am J Audiol. 2009 Jun;18(1):24-33. (PMID: <searchLink fieldCode="PM" term="%2219029532%22">19029532)</searchLink><br />Acta Otorhinolaryngol Belg. 2003;57(4):227-36. (PMID: <searchLink fieldCode="PM" term="%2214714940%22">14714940)</searchLink><br />Early Hum Dev. 2013 Jan;89(1):43-8. (PMID: <searchLink fieldCode="PM" term="%2222849808%22">22849808)</searchLink><br />Int J Pediatr Otorhinolaryngol. 2013 Dec;77(12):2030-9. (PMID: <searchLink fieldCode="PM" term="%2224182601%22">24182601)</searchLink><br />Int J Pediatr Otorhinolaryngol. 2007 Sep;71(9):1449-56. (PMID: <searchLink fieldCode="PM" term="%2217629955%22">17629955)</searchLink><br />Br Med Bull. 2002;63:171-81. (PMID: <searchLink fieldCode="PM" term="%2212324392%22">12324392)</searchLink><br />J Matern Fetal Neonatal Med. 2012 Aug;25(8):1342-7. (PMID: <searchLink fieldCode="PM" term="%2222122007%22">22122007)</searchLink><br />Otol Neurotol. 2011 Jul;32(5):799-804. (PMID: <searchLink fieldCode="PM" term="%2221593700%22">21593700)</searchLink><br />Int J Pediatr Otorhinolaryngol. 2011 Feb;75(2):163-70. (PMID: <searchLink fieldCode="PM" term="%2221129787%22">21129787)</searchLink><br />Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Aug 20;31(16):1288-1291. (PMID: <searchLink fieldCode="PM" term="%2229798381%22">29798381)</searchLink><br />Dev Med Child Neurol. 2016 Oct;58(10):1009-15. (PMID: <searchLink fieldCode="PM" term="%2227168415%22">27168415)</searchLink><br />Acta Otorhinolaryngol Ital. 2019 Aug;39(4):257-262. (PMID: <searchLink fieldCode="PM" term="%2231501617%22">31501617)</searchLink><br />Int J Pediatr Otorhinolaryngol. 2001 Feb;57(2):137-44. (PMID: <searchLink fieldCode="PM" term="%2211165651%22">11165651)</searchLink><br />J Paediatr Child Health. 2016 Nov;52(11):995-1003. (PMID: <searchLink fieldCode="PM" term="%2227521761%22">27521761)</searchLink><br />Int Arch Otorhinolaryngol. 2017 Jul;21(3):200-205. (PMID: <searchLink fieldCode="PM" term="%2228680486%22">28680486)</searchLink>
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