Academic Journal
Exploration of Changes in the Human Skin Microbiome by Mode of Birth and Following First Bath.
| Τίτλος: | Exploration of Changes in the Human Skin Microbiome by Mode of Birth and Following First Bath. |
|---|---|
| Συγγραφείς: | Capone K; Kenvue Brands LLC, Summit, New Jersey, USA., Kuller J; The Newborn Intensive Care Unit, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA., Durand DJ; Division of Neonatology, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA., Tierney NK; Kenvue Brands LLC, Summit, New Jersey, USA., Lund C; The Newborn Intensive Care Unit, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA. |
| Πηγή: | Pediatric dermatology [Pediatr Dermatol] 2026 Sep-Oct; Vol. 43 (5), pp. 1046-1053. Date of Electronic Publication: 2026 Apr 28. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 8406799 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1470 (Electronic) Linking ISSN: 07368046 NLM ISO Abbreviation: Pediatr Dermatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010->: Hoboken, NJ : Wiley Original Publication: [Boston, MA] : Blackwell Scientific Publications, [1983- |
| Ιατρικοί όροι (MeSH): | Delivery, Obstetric*/methods , Skin*/microbiology , Skin Microbiome* , Baths* , Cesarean Section* , Microbiota*, Humans ; Female ; Infant, Newborn ; Male ; Pregnancy ; RNA, Ribosomal, 16S |
| Περίληψη: | Background/objectives: Microbes colonize the skin soon after birth, and the skin microbiome changes over time. However, the effects of bathing and hygiene products on the infant skin microbiome are not well studied. This randomized, single-center trial analyzed the skin microbiome in neonates born vaginally or via cesarean section (c-section), before and after their first bath with or without a mild baby cleanser. Methods: One hundred healthy full-term neonates were randomized to baths with water alone or with mild baby cleanser, stratified by delivery mode. Volar forearm swabs of neonates (before and after first bath) and their mothers were analyzed by 16S rRNA metagenomic sequencing. Results: At birth, neonates born vaginally had greater overall richness of the skin microbiome versus those born via c-section. Vaginally delivered neonates had similar species richness as their mothers, while neonates delivered via c-section had much lower species richness. Shannon diversity was similar regardless of birth mode, but community structure varied. Species richness was similar before and after bath in vaginally delivered neonates, but those born via c-section had higher species richness after their first bath and showed larger changes in community structures, compared with the vaginal group. Whether water alone or baby cleanser was used for the first bath did not greatly affect skin microbiome composition. Conclusions: The mode of birth had the largest effect on the skin microbiome composition, richness, and structure. Neonates born via c-section showed the largest post-bath changes in the skin microbiome, while the use of water or baby cleanser had little effect. (© 2026 Wiley Periodicals LLC.) |
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| Grant Information: | UL1 TR000004 United States TR NCATS NIH HHS; Johnson & Johnson Consumer Inc.; UL1 TR000004 National Center for Advancing Translational Sciences, National Institutes of Health |
| Contributed Indexing: | Keywords: bath; microbiome; neonates; newborn; skin |
| Substance Nomenclature: | 0 (RNA, Ribosomal, 16S) |
| Entry Date(s): | Date Created: 20260428 Date Completed: 20260928 Latest Revision: 20260929 |
| Update Code: | 20260930 |
| DOI: | 10.1111/pde.70219 |
| PMID: | 42047611 |
| Βάση Δεδομένων: | MEDLINE |
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