Academic Journal
A Systematic Review of Clinical Phenomenology, Differential Diagnosis and Prognostic Outcomes of Substance-Induced Psychotic Disorders.
| Τίτλος: | A Systematic Review of Clinical Phenomenology, Differential Diagnosis and Prognostic Outcomes of Substance-Induced Psychotic Disorders. |
|---|---|
| Συγγραφείς: | Ricci V; San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy., Martinotti G; Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi G. D'Annunzio Chieti-Pescara, Chieti, Italy., Maina G; San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.; Department of Neurosciences 'Rita Levi Montalcini,' University of Turin, Italy. |
| Πηγή: | The International journal of social psychiatry [Int J Soc Psychiatry] 2026 Aug; Vol. 72 (5), pp. 1070-1086. Date of Electronic Publication: 2026 Apr 26. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Sage Publications Country of Publication: England NLM ID: 0374726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-2854 (Electronic) Linking ISSN: 00207640 NLM ISO Abbreviation: Int J Soc Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2002->: London : Sage Publications Original Publication: London Avenue Publishing Co |
| Ιατρικοί όροι (MeSH): | Psychoses, Substance-Induced*/diagnosis, Humans ; Diagnosis, Differential ; Prognosis |
| Περίληψη: | Background: Distinguishing substance-induced psychotic disorders (SIPD) from primary psychotic disorders with concurrent substance use remains a critical diagnostic challenge for treatment planning and prognostic counseling. Objective: To systematically review the clinical phenomenology of SIPD, identify distinguishing symptom patterns, and examine relationships between phenomenology and outcomes. Methods: A systematic search of PubMed, PsycINFO, and Web of Science (1990-2025) was conducted for studies examining clinical characteristics of SIPD using standardized diagnostic criteria and validated instruments. Study quality was assessed using the Newcastle-Ottawa Scale. The review was registered on PROSPERO (CRD42025123563; 19/11/2025). Results: Thirty-six studies encompassing over 80,000 individuals were included. Cannabis-induced psychosis was consistently characterized by prominent positive symptoms, preserved negative domains, and elevated affective and anxiety features, with transition rates to schizophrenia spectrum disorders ranging from 36% to 46%. Methamphetamine-induced psychosis presented along a phenomenological gradient, from simple persecutory delusions and tactile hallucinations in transient cases-accompanied by markedly elevated violence rates (75.6%)-to complex multimodal sensory disturbances in persistent presentations. Despite these substance-specific signatures, substantial phenomenological overlap with primary psychotic disorders and poor diagnostic stability, with 25% to 39% of initial SIPD diagnoses converting to primary disorders over follow-up, limit the utility of cross-sectional assessment alone. Superior antipsychotic response at lower doses emerged as a potential marker favoring substance-induced over primary etiology. Conclusions: SIPD exhibit distinctive phenomenological signatures varying by substance class, yet considerable overlap with primary psychotic disorders and poor diagnostic stability underscore the necessity of longitudinal monitoring and integrated psychiatric-addiction care. |
| Competing Interests: | Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Contributed Indexing: | Keywords: cannabis; methamphetamine; psychotic disorders; schizophrenia; substance-induced psychosis |
| Entry Date(s): | Date Created: 20260427 Date Completed: 20260814 Latest Revision: 20260910 |
| Update Code: | 20260910 |
| DOI: | 10.1177/00207640261439774 |
| PMID: | 42037032 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!