Academic Journal
Structurally diverse diterpenoids from Euphorbia milii: Discovery and RORγt-binding evaluation.
| Title: | Structurally diverse diterpenoids from Euphorbia milii: Discovery and RORγt-binding evaluation. |
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| Authors: | Dai MY; Yunnan Key Laboratory of Genetic Improvement of Herbal Oil Crops, Industrial Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, 650225, PR China., Hu XL; Yunnan Key Laboratory of Genetic Improvement of Herbal Oil Crops, Industrial Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, 650225, PR China., Li WC; Yunnan Key Laboratory of Genetic Improvement of Herbal Oil Crops, Industrial Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, 650225, PR China., Lu Z; Department of Pulmonary and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, PR China., Jiang BY; Department of Central laboratory, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410018, PR China., Chen HM; Department of Pulmonary and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, PR China., Zeng Y; Department of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410018, PR China., Cao DH; Department of Central laboratory, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410018, PR China; Department of Pulmonary and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, PR China. Electronic address: caodonghua@usc.edu.cn. |
| Source: | Phytochemistry [Phytochemistry] 2026 Sep; Vol. 249, pp. 114934. Date of Electronic Publication: 2026 Apr 23. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| MeSH Terms: | Euphorbia*/chemistry , Diterpenes*/chemistry , Diterpenes*/pharmacology , Diterpenes*/isolation & purification , Nuclear Receptor Subfamily 1, Group F, Member 3*/metabolism, Cell Differentiation/drug effects ; Th17 Cells/drug effects ; Molecular Structure ; Animals ; Mice |
| Abstract: | Ten previously undescribed diterpenoids (1-10), representing four diverse architectural types, along with eight known analogs (11-18), were isolated from Euphorbia milii. Compounds 1-3 were characterized as ent-atisane diterpenoids, with 1 and 2 featuring a C-19-nor- and a 3,4-seco-19-nor-ent-atisane framework, respectively, and their plausible biosynthetic pathways were proposed. The remaining new isolates were established to be ent-pimarane (4-7), ent-abietane (8 and 9), and ent-verticillane (10) diterpenoids. Binding affinity assays revealed that compounds 6, 7, and 14 bound directly to retinoic acid-related orphan receptor γt (RORγt), of which 14 demonstrated the highest affinity (K (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Diterpenoids; Euphorbia milii; Euphorbiaceae; RORγt; Structure elucidation; Th17 cell differentiation |
| Substance Nomenclature: | 0 (Diterpenes) 0 (Nuclear Receptor Subfamily 1, Group F, Member 3) |
| Entry Date(s): | Date Created: 20260425 Date Completed: 20260610 Latest Revision: 20260610 |
| Update Code: | 20260610 |
| DOI: | 10.1016/j.phytochem.2026.114934 |
| PMID: | 42034227 |
| Database: | MEDLINE |
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