Academic Journal
Factors associated with radiographic progression of hand osteoarthritis over 2 years.
| Τίτλος: | Factors associated with radiographic progression of hand osteoarthritis over 2 years. |
|---|---|
| Συγγραφείς: | van der Meulen C; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., van de Stadt LA; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, The Netherlands., Reijnierse M; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., van Beest S; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands G.Kloppenburg@lumc.nl. |
| Πηγή: | RMD open [RMD Open] 2026 Apr 24; Vol. 12 (2). Date of Electronic Publication: 2026 Apr 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BMJ Publishing Group, [2015]- |
| Ιατρικοί όροι (MeSH): | Osteoarthritis*/diagnostic imaging , Osteoarthritis*/diagnosis , Osteoarthritis*/etiology , Osteoarthritis*/pathology , Osteoarthritis*/epidemiology , Radiography*/methods , Hand Joints*/diagnostic imaging , Hand Joints*/pathology, Osteophyte/diagnostic imaging ; Humans ; Female ; Disease Progression ; Middle Aged ; Male ; Magnetic Resonance Imaging ; Aged ; Risk Factors ; Severity of Illness Index |
| Περίληψη: | Purpose: To characterise radiographic progression over 2 years and associated characteristics in patients with hand osteoarthritis. Methods: Baseline and year 2 data from the Hand OSTeoArthritis in Secondary (HOSTAS) care cohort were used, including patients from a rheumatology outpatient clinic.We collected demographics, disease and patient characteristics and MRI scans of the right hand. Erosive disease was classified using the Verbruggen-Veys system.Dorso-volar hand radiographs were scored blinded, paired, in chronological order, with the Osteoarthritis Research Society International system (osteophytes and joint space narrowing (JSN), scored 0-3/0-1, depending on the joint) per joint (sum score 0-88), with high to excellent reliability. We used the smallest detectable changes to classify progressors (all joints, thumb-base joints and IP joints).Associations between progression and characteristics were analysed with logistic regression. Results: Among 417 patients (mean age 61 years, 86% female), 272 (65%) showed osteophyte progression (median sum score (IQR) change 1 (0-2)) and 135 (32%) JSN progression (median sum score (IQR) change 1 (0-2)). Both osteophyte and JSN progressors had more radiographic damage at baseline. Associations were found between baseline erosive disease or bone marrow lesions and osteophyte progression in IP joints, and between female sex and osteophyte progression in thumb-base joints. The association of baseline osteophytes with change in osteophytes was strongest in younger females. Conclusion: Over 2 years, a considerable proportion of patients demonstrated radiographic progression. Progressors were especially those with erosive disease, more radiographic damage (most pronounced in younger females) and bone marrow lesions at baseline. (© Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: MK reports the following, all outside the current study: a grant from IMI-APPROACH, paid to the institution; royalties or licences from Wolters Kluwer and Springer Verlag, paid to the institution; fees for consulting or advisory boards from Pfizer, UCB, CHDR, GSK, Novartis and Peptinov, all paid to the institution; payment or honoraria for lectures or presentations from Novartis, paid to the institution and roles on the OARSI board (member), the EULAR council (chair of the advocacy committee) and the presidency of the Dutch Society for Rheumatology. For the current study, MK reports funding from the Dutch Arthritis Society, paid to the institution. MR reports the following, all outside the current study: an ISS grant and a consultant role for ASAS. All other authors have no competing interests to declare. |
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| Contributed Indexing: | Keywords: Epidemiology; Osteoarthritis; Risk Factors |
| Entry Date(s): | Date Created: 20260424 Date Completed: 20260715 Latest Revision: 20260813 |
| Update Code: | 20260919 |
| PubMed Central ID: | PMC13110703 |
| DOI: | 10.1136/rmdopen-2025-006684 |
| PMID: | 42031509 |
| Βάση Δεδομένων: | MEDLINE |
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