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Causal association between sleep disorders and nephrolithiasis: a two-sample Mendelian randomization study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Causal association between sleep disorders and nephrolithiasis: a two-sample Mendelian randomization study.
Συγγραφείς: Huang L; Department of Respiratory Diseases, General Hospital of Northern Theater Command, Shenyang, 110015, China., Fan L; Department of Urology, General Hospital of Northern Theater Command, Shenyang, 110015, China., Wang S; Jinzhou Medical University, Jinzhou, 121001, China., Liu H; Department of Urology, General Hospital of Northern Theater Command, Shenyang, 110015, China., Zeng Q; Department of Respiratory Diseases, General Hospital of Northern Theater Command, Shenyang, 110015, China., Sun G; Department of Urology, General Hospital of Northern Theater Command, Shenyang, 110015, China. 13309880419@163.com.
Πηγή: International urology and nephrology [Int Urol Nephrol] 2026 Oct; Vol. 58 (10), pp. 4499-4512. Date of Electronic Publication: 2026 Apr 23.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Netherlands NLM ID: 0262521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2584 (Electronic) Linking ISSN: 03011623 NLM ISO Abbreviation: Int Urol Nephrol Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Springer
Original Publication: Budapest, Akademiai Kiadó
Ιατρικοί όροι (MeSH): Nephrolithiasis*/genetics , Nephrolithiasis*/epidemiology , Sleep Wake Disorders*/genetics , Sleep Wake Disorders*/complications , Sleep Apnea Syndromes*/genetics, Humans ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
Περίληψη: Purpose: Observational evidence indicates an association between sleep disorders and the risk of nephrolithiasis (kidney stones), but whether this relationship reflects a causal effect remains uncertain. The causal relationship between genetically determined sleep disorders and the risk of nephrolithiasis using a two-sample Mendelian randomization (MR) approach was investigated.
Methods: This two-sample MR study utilized genome-wide association summary data for both sleep disorders and nephrolithiasis. The main analysis was conducted using the inverse variance weighted method, while confirmatory analyses employed the weighted mode, weighted median, and MR-Egger regression approaches to test for consistency and robustness. Heterogeneity among instrumental variables was evaluated using Cochran's Q-test, and the potential for horizontal pleiotropy was assessed with the MR-Egger regression intercept. To further gauge the robustness and consistency of the findings, a leave-one-out sensitivity analysis was performed, systematically omitting each single-nucleotide polymorphism in turn.
Results: Genetically predicted sleep apnea was associated with nephrolithiasis (OR = 1.0032, 95% CI: 1.0011-1.0053, P = 0.0025) and nephrolithiasis intervention (OR = 1.0027, 95% CI: 1.0008-1.0046, P = 0.0057) and that combined sleep disorders were associated with nephrolithiasis (OR = 1.0042, 95% CI: 1.0014-1.0070, P = 0.0032) and nephrolithiasis intervention (OR = 1.0027, 95% CI: 1.0004-1.0050, P = 0.0240). The MR-Egger test indicated no pleiotropy, and the Q-test revealed no heterogeneity for the causal associations above. The MR-PRESSO test showed no horizontal pleiotropy among the tested SNPs for the identified causal associations. The leave-one-out analysis revealed similar results.
Conclusion: This MR study revealed causal associations between sleep disorders and nephrolithiasis. Further studies are needed to confirm these findings and elucidate the underlying mechanisms.
(© 2026. The Author(s).)
Competing Interests: Declarations. Conflict of interests: The authors declare no competing interests. Ethical approval and consent to participate: Not applicable. Consent for publication: Not applicable.
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J Endourol. 2018 Mar;32(3):236-244. (PMID: 29338314)
Kidney Int. 2005 Aug;68(2):497-503. (PMID: 16014026)
J Urol. 2014 Feb;191(2):372-5. (PMID: 24071479)
BMC Med. 2023 Feb 21;21(1):66. (PMID: 36810112)
Int J Mol Sci. 2019 Jan 22;20(3):. (PMID: 30678164)
J Am Soc Nephrol. 2016 Nov;27(11):3253-3265. (PMID: 27486138)
J Clin Sleep Med. 2018 May 15;14(5):767-773. (PMID: 29734978)
Nephrol Ther. 2021 Apr;17S:S88-S94. (PMID: 33910705)
Urolithiasis. 2023 Mar 7;51(1):46. (PMID: 36881138)
Genet Epidemiol. 2013 Nov;37(7):658-65. (PMID: 24114802)
Stat Med. 2017 May 20;36(11):1783-1802. (PMID: 28114746)
Neurol Genet. 2019 Feb 11;5(2):e310. (PMID: 30863791)
Genet Epidemiol. 2016 May;40(4):304-14. (PMID: 27061298)
Am J Hum Genet. 2017 Jul 6;101(1):5-22. (PMID: 28686856)
Am J Epidemiol. 2013 Oct 1;178(7):1177-84. (PMID: 23863760)
BMJ. 2016 Mar 14;352:i52. (PMID: 26977089)
Oncotarget. 2017 Dec 14;9(6):7204-7218. (PMID: 29467962)
J Am Soc Nephrol. 2023 Dec 1;34(12):1991-2011. (PMID: 37787550)
Int J Epidemiol. 2003 Feb;32(1):1-22. (PMID: 12689998)
Urolithiasis. 2020 Jun;48(3):245-249. (PMID: 31209553)
Biol Psychiatry. 2016 Jul 1;80(1):40-52. (PMID: 26140821)
J Urol. 2014 Aug;192(2):316-24. (PMID: 24857648)
Int J Epidemiol. 2017 Dec 1;46(6):1985-1998. (PMID: 29040600)
JAMA. 2021 Oct 26;326(16):1614-1621. (PMID: 34698778)
Cells. 2021 Jul 29;10(8):. (PMID: 34440695)
Sci Rep. 2021 Mar 18;11(1):6214. (PMID: 33737531)
J Clin Invest. 2025 May 15;135(15):. (PMID: 40372791)
J Neuroinflammation. 2020 Aug 1;17(1):229. (PMID: 32738920)
Genome Res. 2020 Dec;30(12):1789-1801. (PMID: 33060171)
Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253)
Nat Genet. 2018 May;50(5):693-698. (PMID: 29686387)
Biochem Biophys Rep. 2025 Jun 28;43:102116. (PMID: 40678804)
Hum Mol Genet. 2014 Sep 15;23(R1):R89-98. (PMID: 25064373)
J Matern Fetal Neonatal Med. 2024 Dec;37(1):2294691. (PMID: 38146168)
Ann Intern Med. 2014 Nov 4;161(9):659-67. (PMID: 25364887)
Nat Aging. 2022 Jan;2(1):19-30. (PMID: 37118362)
Int J Epidemiol. 2012 Feb;41(1):273-86. (PMID: 22253303)
J Clin Sleep Med. 2009 Jun 15;5(3):263-76. (PMID: 19960649)
Medicine (Baltimore). 2024 May 17;103(20):e38210. (PMID: 38758878)
Nat Sci Sleep. 2022 Sep 21;14:1677-1686. (PMID: 36172082)
BMC Public Health. 2022 Sep 20;22(1):1787. (PMID: 36127664)
J Clin Med. 2021 Dec 23;11(1):. (PMID: 35011807)
J Urol. 2016 Oct;196(4):1161-9. (PMID: 27238615)
Sleep Med Rev. 2017 Aug;34:70-81. (PMID: 27568340)
Sleep Health. 2022 Dec;8(6):671-677. (PMID: 36216750)
Nat Rev Urol. 2020 Jul;17(7):407-421. (PMID: 32533118)
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Rev Endocr Metab Disord. 2015 Mar;16(1):25-34. (PMID: 25502450)
Contributed Indexing: Keywords: Mendelian randomization analysis; Nephrolithiasis; Obstructive; Sleep apnea; Sleep disorders
Entry Date(s): Date Created: 20260423 Date Completed: 20260917 Latest Revision: 20260920
Update Code: 20260920
PubMed Central ID: PMC13585773
DOI: 10.1007/s11255-026-05130-3
PMID: 42026399
Βάση Δεδομένων: MEDLINE
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  Data: Causal association between sleep disorders and nephrolithiasis: a two-sample Mendelian randomization study.
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  Data: <searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Department of Respiratory Diseases, General Hospital of Northern Theater Command, Shenyang, 110015, China.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Department of Urology, General Hospital of Northern Theater Command, Shenyang, 110015, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Jinzhou Medical University, Jinzhou, 121001, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Urology, General Hospital of Northern Theater Command, Shenyang, 110015, China.<br /><searchLink fieldCode="AU" term="%22Zeng+Q%22">Zeng Q</searchLink>; Department of Respiratory Diseases, General Hospital of Northern Theater Command, Shenyang, 110015, China.<br /><searchLink fieldCode="AU" term="%22Sun+G%22">Sun G</searchLink>; Department of Urology, General Hospital of Northern Theater Command, Shenyang, 110015, China. 13309880419@163.com.
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– Name: Abstract
  Label: Abstract
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  Data: Purpose: Observational evidence indicates an association between sleep disorders and the risk of nephrolithiasis (kidney stones), but whether this relationship reflects a causal effect remains uncertain. The causal relationship between genetically determined sleep disorders and the risk of nephrolithiasis using a two-sample Mendelian randomization (MR) approach was investigated.<br />Methods: This two-sample MR study utilized genome-wide association summary data for both sleep disorders and nephrolithiasis. The main analysis was conducted using the inverse variance weighted method, while confirmatory analyses employed the weighted mode, weighted median, and MR-Egger regression approaches to test for consistency and robustness. Heterogeneity among instrumental variables was evaluated using Cochran's Q-test, and the potential for horizontal pleiotropy was assessed with the MR-Egger regression intercept. To further gauge the robustness and consistency of the findings, a leave-one-out sensitivity analysis was performed, systematically omitting each single-nucleotide polymorphism in turn.<br />Results: Genetically predicted sleep apnea was associated with nephrolithiasis (OR = 1.0032, 95% CI: 1.0011-1.0053, P = 0.0025) and nephrolithiasis intervention (OR = 1.0027, 95% CI: 1.0008-1.0046, P = 0.0057) and that combined sleep disorders were associated with nephrolithiasis (OR = 1.0042, 95% CI: 1.0014-1.0070, P = 0.0032) and nephrolithiasis intervention (OR = 1.0027, 95% CI: 1.0004-1.0050, P = 0.0240). The MR-Egger test indicated no pleiotropy, and the Q-test revealed no heterogeneity for the causal associations above. The MR-PRESSO test showed no horizontal pleiotropy among the tested SNPs for the identified causal associations. The leave-one-out analysis revealed similar results.<br />Conclusion: This MR study revealed causal associations between sleep disorders and nephrolithiasis. Further studies are needed to confirm these findings and elucidate the underlying mechanisms.<br /> (© 2026. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Conflict of interests: The authors declare no competing interests. Ethical approval and consent to participate: Not applicable. Consent for publication: Not applicable.
– Name: Ref
  Label: References
  Group: RefInfo
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(PMID: <searchLink fieldCode="PM" term="%2223863760%22">23863760)</searchLink><br />BMJ. 2016 Mar 14;352:i52. (PMID: <searchLink fieldCode="PM" term="%2226977089%22">26977089)</searchLink><br />Oncotarget. 2017 Dec 14;9(6):7204-7218. (PMID: <searchLink fieldCode="PM" term="%2229467962%22">29467962)</searchLink><br />J Am Soc Nephrol. 2023 Dec 1;34(12):1991-2011. (PMID: <searchLink fieldCode="PM" term="%2237787550%22">37787550)</searchLink><br />Int J Epidemiol. 2003 Feb;32(1):1-22. (PMID: <searchLink fieldCode="PM" term="%2212689998%22">12689998)</searchLink><br />Urolithiasis. 2020 Jun;48(3):245-249. (PMID: <searchLink fieldCode="PM" term="%2231209553%22">31209553)</searchLink><br />Biol Psychiatry. 2016 Jul 1;80(1):40-52. (PMID: <searchLink fieldCode="PM" term="%2226140821%22">26140821)</searchLink><br />J Urol. 2014 Aug;192(2):316-24. (PMID: <searchLink fieldCode="PM" term="%2224857648%22">24857648)</searchLink><br />Int J Epidemiol. 2017 Dec 1;46(6):1985-1998. 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      – TitleFull: Causal association between sleep disorders and nephrolithiasis: a two-sample Mendelian randomization study.
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      – PersonEntity:
          Name:
            NameFull: Liu H
      – PersonEntity:
          Name:
            NameFull: Zeng Q
      – PersonEntity:
          Name:
            NameFull: Sun G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1573-2584
          Numbering:
            – Type: volume
              Value: 58
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: International urology and nephrology
              Type: main
ResultId 1