Academic Journal
Alpha-tocopherol intake and status exhibit population-specific associations with metabolic syndrome among two Hispanic/Latinos populations.
| Title: | Alpha-tocopherol intake and status exhibit population-specific associations with metabolic syndrome among two Hispanic/Latinos populations. |
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| Authors: | Costa ML; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Mattei J; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Batista LD; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil., Sales CH; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil., Sarti FM; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil., Rogero MM; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil., Fisberg RM; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil. Electronic address: rfisberg@usp.br. |
| Source: | Nutrition research (New York, N.Y.) [Nutr Res] 2026 Jun; Vol. 150, pp. 19-32. Date of Electronic Publication: 2026 Mar 27. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8303331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0739 (Electronic) Linking ISSN: 02715317 NLM ISO Abbreviation: Nutr Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2004- > : Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon Press, c1981- |
| MeSH Terms: | Metabolic Syndrome*/blood , Metabolic Syndrome*/epidemiology , Metabolic Syndrome*/ethnology , alpha-Tocopherol*/administration & dosage , alpha-Tocopherol*/blood , Hispanic or Latino*/statistics & numerical data , Diet* , Nutritional Status*, Brazil/epidemiology ; Triglycerides/blood ; Cholesterol, HDL/blood ; Humans ; Cross-Sectional Studies ; Female ; Nutrition Surveys ; Male ; Adult ; Middle Aged ; Waist Circumference ; Blood Glucose |
| Abstract: | Adequate alpha-tocopherol intake and status may reduce the risk of metabolic syndrome (MetS), yet evidence among Hispanics/Latinos remains limited. This study examined population-specific associations of alpha-tocopherol intake and status with MetS in two Hispanic/Latino populations and identified the main dietary sources of alpha-tocopherol. We hypothesized that alpha-tocopherol intake and status would be inversely associated with MetS and its components, with distinct food sources across populations. Cross-sectional analysis was conducted from the 2015 Health Survey of São Paulo with a Focus on Nutrition (n = 524) and Hispanic/Latino respondents of the 2017 to 2018 National Health and Nutrition Examination Survey (n = 499). Alpha-tocopherol intake was assessed from two 24-hour recalls, and status from blood plasma samples. MetS was classified based on International Diabetes Federation criteria using standardized laboratory and clinical measures. Poisson regression models considered complex survey design. Alpha-tocopherol intake and status were inversely associated with higher triglycerides and MetS in the São Paulo population. Only alpha-tocopherol status was associated with higher fasting glycemia, higher triglycerides, lower HDL-c, higher waist circumference, and MetS in Hispanic/Latino individuals from the US. The food sources of alpha-tocopherol varied substantially by population. In conclusion, alpha-tocopherol intake and status were associated differently with metabolic syndrome components according to the population, underscoring the need for tailored strategies to improve alpha-tocopherol adequacy for cardiometabolic health. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest All authors declare no conflicts of interest that could inappropriately influence this article. |
| Contributed Indexing: | Keywords: Alpha-tocopherol; Brazil; Hispanics/Latinos; Metabolic syndrome; Vitamin E |
| Substance Nomenclature: | H4N855PNZ1 (alpha-Tocopherol) 0 (Triglycerides) 0 (Blood Glucose) 0 (Cholesterol, HDL) |
| Entry Date(s): | Date Created: 20260423 Date Completed: 20260527 Latest Revision: 20260529 |
| Update Code: | 20260529 |
| DOI: | 10.1016/j.nutres.2026.03.011 |
| PMID: | 42024979 |
| Database: | MEDLINE |
| ISSN: | 1879-0739 |
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| DOI: | 10.1016/j.nutres.2026.03.011 |