Academic Journal
A Study on the Combined Application of Gastroscopy and the Rapid Urease Test in Paediatric Gastric Disorders.
| Τίτλος: | A Study on the Combined Application of Gastroscopy and the Rapid Urease Test in Paediatric Gastric Disorders. |
|---|---|
| Συγγραφείς: | Song X; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Lu H; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Zhao C; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Ma T; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Tian D; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China., Zhang G; Department of Paediatrics, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China. |
| Πηγή: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2026 Apr; Vol. 36 (4), pp. 489-492. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: College of Physicians and Surgeons Pakistan Country of Publication: Pakistan NLM ID: 9606447 Publication Model: Print Cited Medium: Internet ISSN: 1681-7168 (Electronic) Linking ISSN: 1022386X NLM ISO Abbreviation: J Coll Physicians Surg Pak Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Karachi : College of Physicians and Surgeons Pakistan |
| Ιατρικοί όροι (MeSH): | Helicobacter Infections*/diagnosis , Gastroscopy*/methods , Urease*/analysis , Urease*/metabolism , Helicobacter pylori*/isolation & purification , Stomach Diseases*/diagnosis , Stomach Diseases*/microbiology, Breath Tests/methods ; Humans ; Female ; Child ; Male ; Adolescent ; Child, Preschool ; Sensitivity and Specificity ; Biopsy ; China ; Rapid Diagnostic Tests ; ROC Curve |
| Περίληψη: | Objective: To investigate the accuracy, safety, and clinical value of combining gastroscopy with the rapid urease test (RUT) for diagnosing gastric disorders in children. Study Design: A descriptive study. Place and Duration of the Study: Department of Gastroenterology, Maternity and Child Care Centre of Qinhuangdao, Qinhuangdao, China, from January 2024 to June 2025. Methodology: This study included 100 children aged 4-14 years undergoing diagnostic gastroscopy. Multi-site biopsies from the gastric antrum, incisura angularis, and corpus were evaluated using the RUT. Histology and the 13C-urea breath test were the gold standard methods for diagnosing Helicobacter pylori (H. pylori) infection. Diagnostic performance was assessed using sensitivity, specificity, and the area under the ROC curve (AUC). Results: The overall H. pylori infection rate was 31%, with a significantly higher rate in children aged ≥10 years (n = 18, 42.9%) than in those <10 years (n = 13, 22.4%; p = 0.029). The combined approach showed 96.8% sensitivity and 97.1% specificity, with an AUC of 0.961, outperforming gastroscopy alone (AUC = 0.770). The procedure was safe, resulting in only two minor adverse events. Conclusion: Gastroscopy combined with the RUT is an efficient, accurate, and safe method for simultaneously diagnosing gastric lesions and H. pylori infection in children, supporting individualised treatment. Key Words: Paediatrics, Gastric disorders, Gastroscopy, Rapid urease test, Helicobacter pylori, Diagnosis. |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) |
| Entry Date(s): | Date Created: 20260422 Date Completed: 20260715 Latest Revision: 20260715 |
| Update Code: | 20260716 |
| DOI: | 10.29271/jcpsp.2026.04.489 |
| PMID: | 42015435 |
| Βάση Δεδομένων: | MEDLINE |
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