Academic Journal
Glycemic Regulation and Renal Function by Heavy Metal Exposure: A Cross-Sectional Analysis on Cement Plant Workers.
| Τίτλος: | Glycemic Regulation and Renal Function by Heavy Metal Exposure: A Cross-Sectional Analysis on Cement Plant Workers. |
|---|---|
| Συγγραφείς: | Erdoğan DS; Division of Occupational Medicine, Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Türkiye., Bozdag F; Division of Occupational Medicine, Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Türkiye., Topcu FB; Division of Occupational Medicine, Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Türkiye., Demirbas OB; Department of Public Health, Mamak District Health Directorate, Turkish Ministry of Health, Ankara, Türkiye., Cetintepe SP; Division of Occupational Medicine, Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Türkiye., Ilhan MN; Division of Occupational Medicine, Department of Public Health, Faculty of Medicine, Gazi University, Ankara, Türkiye. |
| Πηγή: | Journal of applied toxicology : JAT [J Appl Toxicol] 2026 Oct; Vol. 46 (10), pp. 3550-3560. Date of Electronic Publication: 2026 Apr 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: [Philadelphia, Pa. : Heyden & Son, c1981- |
| Ιατρικοί όροι (MeSH): | Occupational Exposure*/adverse effects , Blood Glucose*/drug effects , Blood Glucose*/metabolism , Blood Glucose*/analysis , Metals, Heavy*/toxicity , Metals, Heavy*/blood , Kidney*/drug effects , Kidney*/physiopathology , Construction Materials*/toxicity, Glycated Hemoglobin/analysis ; Glomerular Filtration Rate/drug effects ; Dust/analysis ; Humans ; Male ; Cross-Sectional Studies ; Adult ; Middle Aged ; Air Pollutants, Occupational ; Glycemic Control |
| Περίληψη: | Heavy metal exposure is known to have various effects on renal function and blood glucose regulation. The main objective of this study was to evaluate the effects of cement dust and some metal (cadmium, manganese, nickel, and zinc) exposure on blood glucose and renal function parameters in male cement plant workers. This study is a cross-sectional study involving male workers from a cement plant who presented to our clinic. Based on their HbA1c levels, the participants were divided into two groups: a prediabetes group (HbA1c ≥ 5.7%) and a control group (HbA1c < 5.7%). The differences between two groups were statistically analyzed. A total of 268 male workers were included in the analysis, 134 in the prediabetes group and 134 in the control group. Blood manganese and nickel levels were statistically significantly higher in the prediabetes group, whereas zinc levels were statistically significantly higher in the control group. There was no statistically significant difference between the groups for cadmium. Low-grade positive correlations were found between manganese and nickel and HbA1c. A low-grade positive correlation was found between GFR and cadmium, and a low-grade negative correlation was found between GFR and manganese. In linear models, those with blood manganese levels above 2 μg/L had higher creatinine and lower GFR. Workplace exposure to heavy metals can induce blood glucose dysregulation and renal dysfunction, particularly in workers engaged in high-exposure jobs. The current situation necessitates the implementation of protective measures to reduce exposure. (© 2026 The Author(s). Journal of Applied Toxicology published by John Wiley & Sons Ltd.) |
| References: | Diabetes Care. 2003 Feb;26(2):468-70. (PMID: 12547882) Front Nutr. 2025 Sep 24;12:1653151. (PMID: 41070026) Environ Res. 2021 Jan;192:110259. (PMID: 33002504) J Korean Med Sci. 2015 Mar;30(3):272-7. (PMID: 25729249) Biol Trace Elem Res. 2013 Dec;156(1-3):79-90. (PMID: 24222606) Lipids Health Dis. 2020 May 28;19(1):112. (PMID: 32466773) BMJ Open. 2026 Jan 14;16(1):e102715. (PMID: 41535075) BMC Endocr Disord. 2014 Mar 08;14:24. (PMID: 24606630) BMC Cancer. 2021 Apr 15;21(1):414. (PMID: 33858386) BMJ Open. 2021 Mar 4;11(3):e039541. (PMID: 33664065) Int J Environ Res Public Health. 2022 Feb 16;19(4):. (PMID: 35206446) Diabetes Metab Syndr Obes. 2022 Mar 03;15:713-721. (PMID: 35264865) J Diabetes Investig. 2022 Aug;13(8):1412-1425. (PMID: 35340117) Chemosphere. 2013 Mar;90(11):2743-9. (PMID: 23261125) Environ Pollut. 2020 Aug;263(Pt A):114630. (PMID: 33618481) Occup Environ Med. 2000 Oct;57(10):668-72. (PMID: 10984338) Ecotoxicol Environ Saf. 2023 Mar 1;252:114601. (PMID: 36753970) Acta Diabetol. 2022 Jul;59(7):965-975. (PMID: 35451678) J Trace Elem Med Biol. 2015;31:78-84. (PMID: 26004896) Environ Int. 2018 Dec;121(Pt 1):683-694. (PMID: 30316184) Ecotoxicol Environ Saf. 2025 Jul 1;299:118369. (PMID: 40412247) Ren Fail. 2025 Dec;47(1):2512049. (PMID: 40467333) Diabetes Care. 2025 Jan 1;48(1 Suppl 1):S27-S49. (PMID: 39651986) Ann Occup Environ Med. 2015 Aug 24;27:20. (PMID: 26306202) Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):e1-e8. (PMID: 29282247) Bull Environ Contam Toxicol. 2012 Dec;89(6):1120-4. (PMID: 23064446) Environ Geochem Health. 2007 Apr;29(2):163-7. (PMID: 17256099) Environ Int. 2021 Apr;149:106406. (PMID: 33508533) Islets. 2009 Nov-Dec;1(3):169-76. (PMID: 21099269) Chemosphere. 2019 Jul;226:321-328. (PMID: 30939371) Sci Total Environ. 2010 Mar 1;408(7):1640-8. (PMID: 20080284) Am J Kidney Dis. 2016 Jun;67(6):841-50. (PMID: 26744126) Toxicology. 2025 Feb;511:154036. (PMID: 39708921) Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839) Cardiovasc Diabetol. 2025 Mar 29;24(1):145. (PMID: 40158078) Environ Geochem Health. 2023 May;45(5):2435-2445. (PMID: 35986857) Environ Geochem Health. 2023 Jun;45(6):3251-3261. (PMID: 36227414) J Cell Biochem. 2018 Jan;119(1):157-184. (PMID: 28643849) PLoS One. 2021 May 11;16(5):e0251554. (PMID: 33974681) Diabetes Care. 2009 Apr;32(4):629-34. (PMID: 19171718) Postgrad Med J. 2023 Jul 21;99(1174):862-867. (PMID: 37137539) Nutr Metab Cardiovasc Dis. 2018 Mar;28(3):234-242. (PMID: 29337019) Chemosphere. 2020 Nov;258:126940. (PMID: 32540546) Diabetologia. 2018 Sep;61(9):1985-1995. (PMID: 29971528) Front Nutr. 2022 Dec 07;9:966500. (PMID: 36570173) Environ Pollut. 2022 Dec 1;314:120331. (PMID: 36195192) Environ Pollut. 2018 Jun;237:917-925. (PMID: 29429611) BMC Public Health. 2010 Jun 03;10:304. (PMID: 20525263) J Diabetes Complications. 2017 Jan;31(1):101-107. (PMID: 27623387) Sci Rep. 2024 Nov 5;14(1):26823. (PMID: 39500961) Nephrology (Carlton). 2018 Sep;23(9):830-836. (PMID: 28632927) |
| Contributed Indexing: | Keywords: cement industry; glycemic control; heavy metals; occupational exposure; renal function |
| Substance Nomenclature: | 0 (Blood Glucose) 0 (Metals, Heavy) 0 (Glycated Hemoglobin) 0 (Air Pollutants, Occupational) 0 (Dust) 0 (hemoglobin A1c protein, human) |
| Entry Date(s): | Date Created: 20260421 Date Completed: 20260901 Latest Revision: 20260903 |
| Update Code: | 20260904 |
| PubMed Central ID: | PMC13532920 |
| DOI: | 10.1002/jat.70204 |
| PMID: | 42014194 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1099-1263 |
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| DOI: | 10.1002/jat.70204 |