Academic Journal
Enhanced Intestinal Absorption of Proteins via a Natural Metabolite-Based Deep Eutectic System.
| Τίτλος: | Enhanced Intestinal Absorption of Proteins via a Natural Metabolite-Based Deep Eutectic System. |
|---|---|
| Συγγραφείς: | Di S; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China., Luo J; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China., Lian Y; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China., Secundo F; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', Consiglio Nazionale Delle Ricerche, Via Mario Bianco 9, Milan 20131, Italy., Mao X; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, China., Huang WC; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, China. |
| Πηγή: | Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jun 03; Vol. 74 (21), pp. 16468-16474. Date of Electronic Publication: 2026 Apr 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Insulin*/metabolism , Insulin*/chemistry , Lactic Acid*/metabolism , Lactic Acid*/chemistry , Betaine*/metabolism , Betaine*/chemistry , Proteins*/metabolism , Proteins*/chemistry , Intestinal Absorption*, Intestinal Mucosa/metabolism ; Animals ; Humans ; Rats |
| Περίληψη: | A natural metabolite-based deep eutectic system composed of betaine and lactic acid (BL-DES) was developed as a food-grade strategy to enhance intestinal absorption of proteins. Insulin was selected as a model protein for convenient and reliable assessment of intestinal absorption. BL-DES reduced the viscosity of simulated intestinal mucus and increased insulin permeability through the mucus layer. Jejunal administration of insulin@BL-DES showed a significant hypoglycemic effect. Hematological, cellular, and histological evaluations confirmed the favorable biocompatibility of BL-DES. Mechanistic investigations revealed that BL-DES promotes paracellular transport through reversible opening of tight junctions. |
| Contributed Indexing: | Keywords: deep eutectic system; intestinal absorption; paracellular transport; peptide; protein |
| Substance Nomenclature: | 0 (Insulin) 33X04XA5AT (Lactic Acid) 3SCV180C9W (Betaine) 0 (Proteins) |
| Entry Date(s): | Date Created: 20260421 Date Completed: 20260605 Latest Revision: 20260605 |
| Update Code: | 20260605 |
| DOI: | 10.1021/acs.jafc.5c13281 |
| PMID: | 42012221 |
| Βάση Δεδομένων: | MEDLINE |
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