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Enhanced Intestinal Absorption of Proteins via a Natural Metabolite-Based Deep Eutectic System.

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Τίτλος: Enhanced Intestinal Absorption of Proteins via a Natural Metabolite-Based Deep Eutectic System.
Συγγραφείς: Di S; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China., Luo J; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China., Lian Y; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China., Secundo F; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', Consiglio Nazionale Delle Ricerche, Via Mario Bianco 9, Milan 20131, Italy., Mao X; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, China., Huang WC; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, China.
Πηγή: Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jun 03; Vol. 74 (21), pp. 16468-16474. Date of Electronic Publication: 2026 Apr 21.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE
Imprint Name(s): Original Publication: Washington, American Chemical Society.
Ιατρικοί όροι (MeSH): Insulin*/metabolism , Insulin*/chemistry , Lactic Acid*/metabolism , Lactic Acid*/chemistry , Betaine*/metabolism , Betaine*/chemistry , Proteins*/metabolism , Proteins*/chemistry , Intestinal Absorption*, Intestinal Mucosa/metabolism ; Animals ; Humans ; Rats
Περίληψη: A natural metabolite-based deep eutectic system composed of betaine and lactic acid (BL-DES) was developed as a food-grade strategy to enhance intestinal absorption of proteins. Insulin was selected as a model protein for convenient and reliable assessment of intestinal absorption. BL-DES reduced the viscosity of simulated intestinal mucus and increased insulin permeability through the mucus layer. Jejunal administration of insulin@BL-DES showed a significant hypoglycemic effect. Hematological, cellular, and histological evaluations confirmed the favorable biocompatibility of BL-DES. Mechanistic investigations revealed that BL-DES promotes paracellular transport through reversible opening of tight junctions.
Contributed Indexing: Keywords: deep eutectic system; intestinal absorption; paracellular transport; peptide; protein
Substance Nomenclature: 0 (Insulin)
33X04XA5AT (Lactic Acid)
3SCV180C9W (Betaine)
0 (Proteins)
Entry Date(s): Date Created: 20260421 Date Completed: 20260605 Latest Revision: 20260605
Update Code: 20260605
DOI: 10.1021/acs.jafc.5c13281
PMID: 42012221
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 42012221
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Enhanced Intestinal Absorption of Proteins via a Natural Metabolite-Based Deep Eutectic System.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Di+S%22">Di S</searchLink>; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Lian+Y%22">Lian Y</searchLink>; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.<br /><searchLink fieldCode="AU" term="%22Secundo+F%22">Secundo F</searchLink>; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', Consiglio Nazionale Delle Ricerche, Via Mario Bianco 9, Milan 20131, Italy.<br /><searchLink fieldCode="AU" term="%22Mao+X%22">Mao X</searchLink>; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, China.<br /><searchLink fieldCode="AU" term="%22Huang+WC%22">Huang WC</searchLink>; State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China.; Qingdao Institute of Marine Bio-Manufacturing Industry, Qingdao Key Laboratory of Green Manufacturing of Marine Bioproducts, Qingdao 266071, China.; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, China.
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  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220374755%22">Journal of agricultural and food chemistry</searchLink> [J Agric Food Chem] 2026 Jun 03; Vol. 74 (21), pp. 16468-16474. <i>Date of Electronic Publication: </i>2026 Apr 21.
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  Data: Journal Article
– Name: Language
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  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0374755 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-5118 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200218561%22">00218561 </searchLink><i>NLM ISO Abbreviation: </i>J Agric Food Chem <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Washington, American Chemical Society.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Insulin%22">Insulin*</searchLink>/<searchLink fieldCode="MM" term="%22Insulin+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Insulin%22">Insulin*</searchLink>/<searchLink fieldCode="MM" term="%22Insulin+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Lactic+Acid%22">Lactic Acid*</searchLink>/<searchLink fieldCode="MM" term="%22Lactic+Acid+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Lactic+Acid%22">Lactic Acid*</searchLink>/<searchLink fieldCode="MM" term="%22Lactic+Acid+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Betaine%22">Betaine*</searchLink>/<searchLink fieldCode="MM" term="%22Betaine+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Betaine%22">Betaine*</searchLink>/<searchLink fieldCode="MM" term="%22Betaine+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Proteins%22">Proteins*</searchLink>/<searchLink fieldCode="MM" term="%22Proteins+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Proteins%22">Proteins*</searchLink>/<searchLink fieldCode="MM" term="%22Proteins+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Intestinal+Absorption%22">Intestinal Absorption*</searchLink><br /><searchLink fieldCode="MH" term="%22Intestinal+Mucosa%22">Intestinal Mucosa</searchLink>/<searchLink fieldCode="MH" term="%22Intestinal+Mucosa+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A natural metabolite-based deep eutectic system composed of betaine and lactic acid (BL-DES) was developed as a food-grade strategy to enhance intestinal absorption of proteins. Insulin was selected as a model protein for convenient and reliable assessment of intestinal absorption. BL-DES reduced the viscosity of simulated intestinal mucus and increased insulin permeability through the mucus layer. Jejunal administration of insulin@BL-DES showed a significant hypoglycemic effect. Hematological, cellular, and histological evaluations confirmed the favorable biocompatibility of BL-DES. Mechanistic investigations revealed that BL-DES promotes paracellular transport through reversible opening of tight junctions.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>deep eutectic system; intestinal absorption; paracellular transport; peptide; protein
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Insulin)<br />33X04XA5AT (Lactic Acid)<br />3SCV180C9W (Betaine)<br />0 (Proteins)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260421 <i>Date Completed: </i>20260605 <i>Latest Revision: </i>20260605
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260605
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1021/acs.jafc.5c13281
– Name: AN
  Label: PMID
  Group: ID
  Data: 42012221
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42012221
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jafc.5c13281
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 16468
    Subjects:
      – SubjectFull: Intestinal Mucosa metabolism
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Insulin metabolism
        Type: general
      – SubjectFull: Insulin chemistry
        Type: general
      – SubjectFull: Lactic Acid metabolism
        Type: general
      – SubjectFull: Lactic Acid chemistry
        Type: general
      – SubjectFull: Betaine metabolism
        Type: general
      – SubjectFull: Betaine chemistry
        Type: general
      – SubjectFull: Proteins metabolism
        Type: general
      – SubjectFull: Proteins chemistry
        Type: general
      – SubjectFull: Intestinal Absorption
        Type: general
    Titles:
      – TitleFull: Enhanced Intestinal Absorption of Proteins via a Natural Metabolite-Based Deep Eutectic System.
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            – D: 03
              M: 06
              Text: 2026 Jun 03
              Type: published
              Y: 2026
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