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Task-specific cortical modulation induced by Tai Chi during postural control in older adults with diabetic peripheral neuropathy: An fNIRS study.

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Τίτλος: Task-specific cortical modulation induced by Tai Chi during postural control in older adults with diabetic peripheral neuropathy: An fNIRS study.
Συγγραφείς: Duan X; Biomechanics Laboratory College of Human Movement Science, Beijing Sport University, Beijing, China; Shandong Sports Training Center, Jinan, China., Wang X; Shandong Sports Rehabilitation Research Center, Jinan, China., Song Q; College of Sports and Health, Shandong Sport University, Jinan, China., Yin Z; College of Sports and Health, Shandong Sport University, Jinan, China., Mao D; Biomechanics Laboratory College of Human Movement Science, Beijing Sport University, Beijing, China; The Chinese University of Hong Kong, Shenzhen, China. Electronic address: maodewei@cuhk.edu.cn.
Πηγή: Brain research [Brain Res] 2026 Aug 01; Vol. 1884, pp. 150333. Date of Electronic Publication: 2026 Apr 17.
Τύπος έκδοσης: Journal Article; Randomized Controlled Trial
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
Ιατρικοί όροι (MeSH): Postural Balance*/physiology , Diabetic Neuropathies*/physiopathology , Diabetic Neuropathies*/therapy , Tai Ji*/methods , Cerebral Cortex*/physiopathology, Spectroscopy, Near-Infrared/methods ; Motor Cortex/physiopathology ; Humans ; Aged ; Male ; Female ; Middle Aged ; Somatosensory Cortex
Περίληψη: Diabetic peripheral neuropathy (DPN) significantly impairs postural control in older adults. While Tai Chi (TC) improves postural stability in this population, the underlying neural mechanisms remain incompletely understood. This study examined whether TC alters task-evoked cortical activation during static and dynamic postural control in older adults with DPN and whether neural changes are associated with functional improvements. Forty older adults with DPN were stratified by DPN scores and randomly allocated to two groups. The TC group received supervised TC training, while the control group attended health education sessions for 8 weeks. Functional near-infrared spectroscopy (fNIRS) was used to measure changes in hemodynamic responses in the premotor cortex and supplementary motor area (PMC/SMA), primary motor cortex (M1), primary somatosensory cortex (S1), and somatosensory association cortex (SAC) during postural control tasks. After Bonferroni-adjusted post hoc testing, the TC group exhibited reduced PMC/SMA and M1 activation during the static task and increased M1 and S1 activation during the dynamic task compared with baseline. Correspondingly, the TC group showed reduced static sway (COP-RMSml and A95) and improved TUG performance. In correlation analyses with Benjamini-Hochberg FDR correction, changes in PMC/SMA and SAC activation were positively associated with changes in A95 during static postural control. In contrast, no significant correlations were found between cortical activation changes and TUG performance during dynamic postural control. These findings suggest that TC modulates cortical activation in a task-specific way and improves postural control in older adults with DPN through distinct neural mechanisms.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Cortical activation; Diabetic peripheral neuropathy; Functional near-infrared spectroscopy; Older adults; Postural control; Tai Chi
Entry Date(s): Date Created: 20260419 Date Completed: 20260715 Latest Revision: 20260818
Update Code: 20260818
DOI: 10.1016/j.brainres.2026.150333
PMID: 42001989
Βάση Δεδομένων: MEDLINE
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  Data: Task-specific cortical modulation induced by Tai Chi during postural control in older adults with diabetic peripheral neuropathy: An fNIRS study.
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  Data: <searchLink fieldCode="AU" term="%22Duan+X%22">Duan X</searchLink>; Biomechanics Laboratory College of Human Movement Science, Beijing Sport University, Beijing, China; Shandong Sports Training Center, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Shandong Sports Rehabilitation Research Center, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Song+Q%22">Song Q</searchLink>; College of Sports and Health, Shandong Sport University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Yin+Z%22">Yin Z</searchLink>; College of Sports and Health, Shandong Sport University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Mao+D%22">Mao D</searchLink>; Biomechanics Laboratory College of Human Movement Science, Beijing Sport University, Beijing, China; The Chinese University of Hong Kong, Shenzhen, China. Electronic address: maodewei@cuhk.edu.cn.
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  Data: Diabetic peripheral neuropathy (DPN) significantly impairs postural control in older adults. While Tai Chi (TC) improves postural stability in this population, the underlying neural mechanisms remain incompletely understood. This study examined whether TC alters task-evoked cortical activation during static and dynamic postural control in older adults with DPN and whether neural changes are associated with functional improvements. Forty older adults with DPN were stratified by DPN scores and randomly allocated to two groups. The TC group received supervised TC training, while the control group attended health education sessions for 8 weeks. Functional near-infrared spectroscopy (fNIRS) was used to measure changes in hemodynamic responses in the premotor cortex and supplementary motor area (PMC/SMA), primary motor cortex (M1), primary somatosensory cortex (S1), and somatosensory association cortex (SAC) during postural control tasks. After Bonferroni-adjusted post hoc testing, the TC group exhibited reduced PMC/SMA and M1 activation during the static task and increased M1 and S1 activation during the dynamic task compared with baseline. Correspondingly, the TC group showed reduced static sway (COP-RMS<subscript>ml</subscript> and A95) and improved TUG performance. In correlation analyses with Benjamini-Hochberg FDR correction, changes in PMC/SMA and SAC activation were positively associated with changes in A95 during static postural control. In contrast, no significant correlations were found between cortical activation changes and TUG performance during dynamic postural control. These findings suggest that TC modulates cortical activation in a task-specific way and improves postural control in older adults with DPN through distinct neural mechanisms.<br /> (Copyright © 2026 Elsevier B.V. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Cortical activation; Diabetic peripheral neuropathy; Functional near-infrared spectroscopy; Older adults; Postural control; Tai Chi
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        Value: 10.1016/j.brainres.2026.150333
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      – Code: eng
        Text: English
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        StartPage: 150333
    Subjects:
      – SubjectFull: Spectroscopy, Near-Infrared methods
        Type: general
      – SubjectFull: Motor Cortex physiopathology
        Type: general
      – SubjectFull: Humans
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      – SubjectFull: Diabetic Neuropathies physiopathology
        Type: general
      – SubjectFull: Diabetic Neuropathies therapy
        Type: general
      – SubjectFull: Tai Ji methods
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      – TitleFull: Task-specific cortical modulation induced by Tai Chi during postural control in older adults with diabetic peripheral neuropathy: An fNIRS study.
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