Academic Journal
Histological effects of intranasal clove essential oil on the olfactory bulb in a rat model of depression.
| Τίτλος: | Histological effects of intranasal clove essential oil on the olfactory bulb in a rat model of depression. |
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| Συγγραφείς: | Elfakharany W; Human Anatomy & Embryology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: walaafakharany83@med.asu.edu.eg., Shafik MM; Human Anatomy & Embryology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Amin MA; Human Anatomy & Embryology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Mokhtar M; Human Anatomy & Embryology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. |
| Πηγή: | Tissue & cell [Tissue Cell] 2026 Aug; Vol. 101, pp. 103508. Date of Electronic Publication: 2026 Apr 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE |
| Imprint Name(s): | Publication: Edinburgh : Churchill Livingstone Original Publication: Edinburgh, Oliver & Boyd. |
| Ιατρικοί όροι (MeSH): | Olfactory Bulb*/drug effects , Olfactory Bulb*/pathology , Depression*/drug therapy , Depression*/pathology , Clove Oil*/pharmacology , Clove Oil*/administration & dosage , Oils, Volatile*/pharmacology , Oils, Volatile*/administration & dosage, Animals ; Male ; Rats ; Disease Models, Animal ; Administration, Intranasal |
| Περίληψη: | Background: depression is the most widespread psychiatric disorder, making it the fourth leading cause of death among adults. The olfactory system is a component of the limbic system. Repeated exposure to stressful events has been reported to affect emotions and olfactory perception. Clove oil is an essential oil that exhibits immunomodulatory properties and is used in the recovery of olfactory dysfunctions during the COVID-19 outbreak. Aim: Detect the potential hazards of stress-induced depression on the olfactory bulbs and investigate the possible role of clove oil in ameliorating these effects. Material and Methods: Twenty-four adult male albino rats were divided equally into three groups: a control group (I), Group (II): depression group, rats were subjected to CUMS Model for 21 days, then were subdivided equally into group (IIa): rats were sacrificed after 21 days, and group (IIb): rats were left for spontaneous recovery for 14 days, then sacrificed. Group (III): rats were subjected to CUMS Model for 21 days, then clove was applied intranasally (0.02 mL/kg) daily for 14 days, then sacrificed. Olfactory bulb specimens were examined by light microscopy. The depression altered the normal tissue morphology of the bulb; Glomeruli appeared shrunken in the glomerular layer. Mitral cells appeared fewer in number, with deeply stained nuclei. The granule cells were aggregated with areas of vacuolated neuropil. Clove oil group restored the normal architecture of the olfactory bulb. Conclusion: Clove oil has an ameliorating effect on the injury of the olfactory bulb in the depression induced animal model of Albino rats. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest Authors declare no conflict of interest. |
| Contributed Indexing: | Keywords: Bulb; Clove; Corticosterone; Depression; GFAP; Olfactory |
| Substance Nomenclature: | 0 (Clove Oil) 0 (Oils, Volatile) |
| Entry Date(s): | Date Created: 20260414 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260715 |
| DOI: | 10.1016/j.tice.2026.103508 |
| PMID: | 41980326 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1532-3072 |
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| DOI: | 10.1016/j.tice.2026.103508 |