Academic Journal
Action Potential Dynamics During Spreading Depolarization.
| Τίτλος: | Action Potential Dynamics During Spreading Depolarization. |
|---|---|
| Συγγραφείς: | Vinokurova D; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Mingazov B; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Burkhanova-Zakirova G; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Khazipov R; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.; Institut de Neurobiologie de la Méditerranée (INMED), L'Institut National de la Santé et de la Recherche Médicale (INSERM), Aix-Marseille University, 13273 Marseille, France., Nasretdinov A; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia. |
| Πηγή: | Cells [Cells] 2026 Mar 28; Vol. 15 (7). Date of Electronic Publication: 2026 Mar 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Ιατρικοί όροι (MeSH): | Action Potentials*/physiology , Cortical Spreading Depression*/physiology, Neurons/physiology ; Somatosensory Cortex/physiology ; Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Patch-Clamp Techniques |
| Περίληψη: | Spreading depolarizations (SDs) are major pathophysiological events in several brain diseases, including migraine, brain ischemia, trauma, and epilepsy. However, the electrophysiological detection of SDs remains challenging. In this study, we examined changes in spikes (action potentials (APs) and action currents (ACs)) in layer 5 neurons of the somatosensory cortex of anesthetized rats during transient excitation at the onset of high-potassium-induced SDs. During whole-cell recordings, spike amplitude progressively decreased while spike duration increased during gradual neuronal depolarization at SD onset, culminating in depolarization block. A similar decrease in spike amplitude and increase in spike duration were observed during the pre-SD excitation phase in loose cell-attached recordings from single neurons and in cluster analysis of extracellular spikes. Multiple (non-clustered) unit activity also showed decrease in spike amplitude and spike broadening during pre-SD excitation. These findings suggest that dynamic changes in spike amplitude and duration at SD onset could serve as markers for SD detection. |
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| Grant Information: | 24-75-10054 Russian Science Foundation |
| Contributed Indexing: | Keywords: action potential; cortex; local field potential; membrane potential; migraine; neuron; patch-clamp; single unit activity; spreading depolarization |
| Entry Date(s): | Date Created: 20260413 Date Completed: 20260715 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13072004 |
| DOI: | 10.3390/cells15070602 |
| PMID: | 41972692 |
| Βάση Δεδομένων: | MEDLINE |
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