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Action Potential Dynamics During Spreading Depolarization.

Bibliographic Details
Title: Action Potential Dynamics During Spreading Depolarization.
Authors: Vinokurova D; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Mingazov B; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Burkhanova-Zakirova G; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Khazipov R; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.; Institut de Neurobiologie de la Méditerranée (INMED), L'Institut National de la Santé et de la Recherche Médicale (INSERM), Aix-Marseille University, 13273 Marseille, France., Nasretdinov A; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.
Source: Cells [Cells] 2026 Mar 28; Vol. 15 (7). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
Imprint Name(s): Original Publication: Basel, Switzerland : MDPI
MeSH Terms: Action Potentials*/physiology , Cortical Spreading Depression*/physiology, Neurons/physiology ; Somatosensory Cortex/physiology ; Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Patch-Clamp Techniques
Abstract: Spreading depolarizations (SDs) are major pathophysiological events in several brain diseases, including migraine, brain ischemia, trauma, and epilepsy. However, the electrophysiological detection of SDs remains challenging. In this study, we examined changes in spikes (action potentials (APs) and action currents (ACs)) in layer 5 neurons of the somatosensory cortex of anesthetized rats during transient excitation at the onset of high-potassium-induced SDs. During whole-cell recordings, spike amplitude progressively decreased while spike duration increased during gradual neuronal depolarization at SD onset, culminating in depolarization block. A similar decrease in spike amplitude and increase in spike duration were observed during the pre-SD excitation phase in loose cell-attached recordings from single neurons and in cluster analysis of extracellular spikes. Multiple (non-clustered) unit activity also showed decrease in spike amplitude and spike broadening during pre-SD excitation. These findings suggest that dynamic changes in spike amplitude and duration at SD onset could serve as markers for SD detection.
References: Nat Med. 2011 Apr;17(4):439-47. (PMID: 21475241)
J Headache Pain. 2025 Dec 3;26(1):278. (PMID: 41340021)
J Neurophysiol. 2006 Jun;95(6):3865-74. (PMID: 16510775)
J Cereb Blood Flow Metab. 2011 Jan;31(1):17-35. (PMID: 21045864)
Front Syst Neurosci. 2020 Aug 04;14:52. (PMID: 32848644)
J Cereb Blood Flow Metab. 2017 May;37(5):1748-1762. (PMID: 27562866)
J Neural Eng. 2011 Apr;8(2):025027. (PMID: 21436513)
Brain. 2022 May 24;145(4):1264-1284. (PMID: 35411920)
Neurocrit Care. 2022 Jun;37(Suppl 1):83-101. (PMID: 35257321)
Cephalalgia. 2025 Sep;45(9):3331024251370629. (PMID: 40891631)
Neuron. 2019 Feb 6;101(3):500-513.e5. (PMID: 30635232)
Front Cell Neurosci. 2017 Dec 21;11:408. (PMID: 29311836)
J Physiol. 2007 May 15;581(Pt 1):139-54. (PMID: 17317752)
Front Cell Neurosci. 2017 Dec 15;11:390. (PMID: 29326550)
J Cereb Blood Flow Metab. 2017 May;37(5):1595-1625. (PMID: 27317657)
J Neurophysiol. 1982 Dec;48(6):1302-20. (PMID: 6296328)
Nat Rev Neurol. 2025 Oct;21(10):529-543. (PMID: 40813918)
J Physiol. 1999 Nov 15;521 Pt 1:135-46. (PMID: 10562340)
J Physiol. 1996 May 15;493 ( Pt 1):83-97. (PMID: 8735696)
J Neurosci. 1997 Apr 1;17(7):2567-79. (PMID: 9065516)
Nat Rev Neurosci. 2014 Jun;15(6):379-93. (PMID: 24857965)
J Neurophysiol. 1956 Mar;19(2):154-71. (PMID: 13295838)
Nat Commun. 2023 Nov 25;14(1):7729. (PMID: 38007508)
Exp Brain Res. 1988;69(3):489-96. (PMID: 3371433)
J Cereb Blood Flow Metab. 2020 Oct;40(10):1934-1952. (PMID: 32580670)
J Neurosci. 1997 Sep 1;17(17):6639-46. (PMID: 9254676)
J Neurobiol. 1970;2(1):47-60. (PMID: 5526716)
Nat Rev Neurosci. 2012 May 18;13(6):407-20. (PMID: 22595786)
Cereb Cortex. 2015 Aug;25(8):2001-21. (PMID: 24518757)
J Neurophysiol. 2014 Dec 1;112(11):2779-90. (PMID: 25185810)
J Physiol. 1978 Oct;283:1-21. (PMID: 722569)
J Headache Pain. 2025 Nov 11;26(1):251. (PMID: 41219828)
J Clin Invest. 2020 May 1;130(5):2286-2300. (PMID: 32250339)
J Neurosci. 1994 Nov;14(11 Pt 2):7087-98. (PMID: 7965100)
J Cereb Blood Flow Metab. 2022 Oct;42(10):1944-1960. (PMID: 35702017)
eNeuro. 2021 Aug 25;8(4):. (PMID: 34380654)
J Neurophysiol. 1947 Nov;10(6):409-14. (PMID: 20268874)
Sci Transl Med. 2025 Sep 17;17(816):eadv3260. (PMID: 40961224)
Front Cell Neurosci. 2022 Feb 10;16:837650. (PMID: 35237133)
J Cereb Blood Flow Metab. 2017 May;37(5):1571-1594. (PMID: 27328690)
J Neurophysiol. 2006 May;95(5):3113-28. (PMID: 16467426)
Brain. 2015 Oct;138(Pt 10):2891-906. (PMID: 26187332)
J Neurophysiol. 1996 Aug;76(2):651-67. (PMID: 8871189)
Nat Rev Neurosci. 2007 Jun;8(6):451-65. (PMID: 17514198)
J Physiol. 2001 Oct 15;536(Pt 2):521-31. (PMID: 11600686)
J Cereb Blood Flow Metab. 2017 May;37(5):1670-1686. (PMID: 27356551)
Epilepsia. 2019 Dec;60(12):2386-2397. (PMID: 31755112)
J Physiol. 2003 Oct 15;552(Pt 2):483-97. (PMID: 14561831)
Neuron. 2015 May 20;86(4):902-922. (PMID: 25996134)
Nat Commun. 2025 May 18;16(1):4619. (PMID: 40383825)
J Neurophysiol. 2005 Aug;94(2):943-51. (PMID: 15800073)
Nat Methods. 2024 May;21(5):914-921. (PMID: 38589517)
Electroencephalogr Clin Neurophysiol. 1951 Aug;3(3):315-21. (PMID: 14879782)
J Neurosci. 2021 Jan 27;41(4):766-779. (PMID: 33229500)
JAMA Neurol. 2020 Apr 1;77(4):489-499. (PMID: 31886870)
J Neurosci. 2016 Apr 27;36(17):4733-43. (PMID: 27122032)
Neurosci Lett. 1993 Apr 2;152(1-2):65-8. (PMID: 8515881)
Cell Biochem Biophys. 2001;35(2):171-90. (PMID: 11892790)
Physiol Rev. 2015 Jul;95(3):953-93. (PMID: 26133935)
J Physiol. 2005 Nov 15;569(Pt 1):41-57. (PMID: 16141270)
Science. 1982 May 14;216(4547):745-7. (PMID: 7079735)
Neurocrit Care. 2022 Jun;37(Suppl 1):31-48. (PMID: 35174446)
Physiol Rev. 2001 Jul;81(3):1065-96. (PMID: 11427692)
Grant Information: 24-75-10054 Russian Science Foundation
Contributed Indexing: Keywords: action potential; cortex; local field potential; membrane potential; migraine; neuron; patch-clamp; single unit activity; spreading depolarization
Entry Date(s): Date Created: 20260413 Date Completed: 20260715 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13072004
DOI: 10.3390/cells15070602
PMID: 41972692
Database: MEDLINE
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  Data: Action Potential Dynamics During Spreading Depolarization.
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  Data: <searchLink fieldCode="AU" term="%22Vinokurova+D%22">Vinokurova D</searchLink>; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Mingazov+B%22">Mingazov B</searchLink>; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Burkhanova-Zakirova+G%22">Burkhanova-Zakirova G</searchLink>; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.<br /><searchLink fieldCode="AU" term="%22Khazipov+R%22">Khazipov R</searchLink>; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.; Institut de Neurobiologie de la Méditerranée (INMED), L'Institut National de la Santé et de la Recherche Médicale (INSERM), Aix-Marseille University, 13273 Marseille, France.<br /><searchLink fieldCode="AU" term="%22Nasretdinov+A%22">Nasretdinov A</searchLink>; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.
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  Data: <searchLink fieldCode="MM" term="%22Action+Potentials%22">Action Potentials*</searchLink>/<searchLink fieldCode="MM" term="%22Action+Potentials+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cortical+Spreading+Depression%22">Cortical Spreading Depression*</searchLink>/<searchLink fieldCode="MM" term="%22Cortical+Spreading+Depression+physiology%22">physiology</searchLink><br /><searchLink fieldCode="MH" term="%22Neurons%22">Neurons</searchLink>/<searchLink fieldCode="MH" term="%22Neurons+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Somatosensory+Cortex%22">Somatosensory Cortex</searchLink>/<searchLink fieldCode="MH" term="%22Somatosensory+Cortex+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%2C+Sprague-Dawley%22">Rats, Sprague-Dawley</searchLink> ; <searchLink fieldCode="MH" term="%22Patch-Clamp+Techniques%22">Patch-Clamp Techniques</searchLink>
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  Data: Spreading depolarizations (SDs) are major pathophysiological events in several brain diseases, including migraine, brain ischemia, trauma, and epilepsy. However, the electrophysiological detection of SDs remains challenging. In this study, we examined changes in spikes (action potentials (APs) and action currents (ACs)) in layer 5 neurons of the somatosensory cortex of anesthetized rats during transient excitation at the onset of high-potassium-induced SDs. During whole-cell recordings, spike amplitude progressively decreased while spike duration increased during gradual neuronal depolarization at SD onset, culminating in depolarization block. A similar decrease in spike amplitude and increase in spike duration were observed during the pre-SD excitation phase in loose cell-attached recordings from single neurons and in cluster analysis of extracellular spikes. Multiple (non-clustered) unit activity also showed decrease in spike amplitude and spike broadening during pre-SD excitation. These findings suggest that dynamic changes in spike amplitude and duration at SD onset could serve as markers for SD detection.
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(PMID: <searchLink fieldCode="PM" term="%2235411920%22">35411920)</searchLink><br />Neurocrit Care. 2022 Jun;37(Suppl 1):83-101. (PMID: <searchLink fieldCode="PM" term="%2235257321%22">35257321)</searchLink><br />Cephalalgia. 2025 Sep;45(9):3331024251370629. (PMID: <searchLink fieldCode="PM" term="%2240891631%22">40891631)</searchLink><br />Neuron. 2019 Feb 6;101(3):500-513.e5. (PMID: <searchLink fieldCode="PM" term="%2230635232%22">30635232)</searchLink><br />Front Cell Neurosci. 2017 Dec 21;11:408. (PMID: <searchLink fieldCode="PM" term="%2229311836%22">29311836)</searchLink><br />J Physiol. 2007 May 15;581(Pt 1):139-54. (PMID: <searchLink fieldCode="PM" term="%2217317752%22">17317752)</searchLink><br />Front Cell Neurosci. 2017 Dec 15;11:390. (PMID: <searchLink fieldCode="PM" term="%2229326550%22">29326550)</searchLink><br />J Cereb Blood Flow Metab. 2017 May;37(5):1595-1625. (PMID: <searchLink fieldCode="PM" term="%2227317657%22">27317657)</searchLink><br />J Neurophysiol. 1982 Dec;48(6):1302-20. (PMID: <searchLink fieldCode="PM" term="%226296328%22">6296328)</searchLink><br />Nat Rev Neurol. 2025 Oct;21(10):529-543. (PMID: <searchLink fieldCode="PM" term="%2240813918%22">40813918)</searchLink><br />J Physiol. 1999 Nov 15;521 Pt 1:135-46. (PMID: <searchLink fieldCode="PM" term="%2210562340%22">10562340)</searchLink><br />J Physiol. 1996 May 15;493 ( Pt 1):83-97. (PMID: <searchLink fieldCode="PM" term="%228735696%22">8735696)</searchLink><br />J Neurosci. 1997 Apr 1;17(7):2567-79. (PMID: <searchLink fieldCode="PM" term="%229065516%22">9065516)</searchLink><br />Nat Rev Neurosci. 2014 Jun;15(6):379-93. (PMID: <searchLink fieldCode="PM" term="%2224857965%22">24857965)</searchLink><br />J Neurophysiol. 1956 Mar;19(2):154-71. (PMID: <searchLink fieldCode="PM" term="%2213295838%22">13295838)</searchLink><br />Nat Commun. 2023 Nov 25;14(1):7729. (PMID: <searchLink fieldCode="PM" term="%2238007508%22">38007508)</searchLink><br />Exp Brain Res. 1988;69(3):489-96. (PMID: <searchLink fieldCode="PM" term="%223371433%22">3371433)</searchLink><br />J Cereb Blood Flow Metab. 2020 Oct;40(10):1934-1952. (PMID: <searchLink fieldCode="PM" term="%2232580670%22">32580670)</searchLink><br />J Neurosci. 1997 Sep 1;17(17):6639-46. (PMID: <searchLink fieldCode="PM" term="%229254676%22">9254676)</searchLink><br />J Neurobiol. 1970;2(1):47-60. (PMID: <searchLink fieldCode="PM" term="%225526716%22">5526716)</searchLink><br />Nat Rev Neurosci. 2012 May 18;13(6):407-20. (PMID: <searchLink fieldCode="PM" term="%2222595786%22">22595786)</searchLink><br />Cereb Cortex. 2015 Aug;25(8):2001-21. (PMID: <searchLink fieldCode="PM" term="%2224518757%22">24518757)</searchLink><br />J Neurophysiol. 2014 Dec 1;112(11):2779-90. (PMID: <searchLink fieldCode="PM" term="%2225185810%22">25185810)</searchLink><br />J Physiol. 1978 Oct;283:1-21. (PMID: <searchLink fieldCode="PM" term="%22722569%22">722569)</searchLink><br />J Headache Pain. 2025 Nov 11;26(1):251. (PMID: <searchLink fieldCode="PM" term="%2241219828%22">41219828)</searchLink><br />J Clin Invest. 2020 May 1;130(5):2286-2300. (PMID: <searchLink fieldCode="PM" term="%2232250339%22">32250339)</searchLink><br />J Neurosci. 1994 Nov;14(11 Pt 2):7087-98. (PMID: <searchLink fieldCode="PM" term="%227965100%22">7965100)</searchLink><br />J Cereb Blood Flow Metab. 2022 Oct;42(10):1944-1960. (PMID: <searchLink fieldCode="PM" term="%2235702017%22">35702017)</searchLink><br />eNeuro. 2021 Aug 25;8(4):. (PMID: <searchLink fieldCode="PM" term="%2234380654%22">34380654)</searchLink><br />J Neurophysiol. 1947 Nov;10(6):409-14. (PMID: <searchLink fieldCode="PM" term="%2220268874%22">20268874)</searchLink><br />Sci Transl Med. 2025 Sep 17;17(816):eadv3260. (PMID: <searchLink fieldCode="PM" term="%2240961224%22">40961224)</searchLink><br />Front Cell Neurosci. 2022 Feb 10;16:837650. (PMID: <searchLink fieldCode="PM" term="%2235237133%22">35237133)</searchLink><br />J Cereb Blood Flow Metab. 2017 May;37(5):1571-1594. (PMID: <searchLink fieldCode="PM" term="%2227328690%22">27328690)</searchLink><br />J Neurophysiol. 2006 May;95(5):3113-28. (PMID: <searchLink fieldCode="PM" term="%2216467426%22">16467426)</searchLink><br />Brain. 2015 Oct;138(Pt 10):2891-906. (PMID: <searchLink fieldCode="PM" term="%2226187332%22">26187332)</searchLink><br />J Neurophysiol. 1996 Aug;76(2):651-67. (PMID: <searchLink fieldCode="PM" term="%228871189%22">8871189)</searchLink><br />Nat Rev Neurosci. 2007 Jun;8(6):451-65. (PMID: <searchLink fieldCode="PM" term="%2217514198%22">17514198)</searchLink><br />J Physiol. 2001 Oct 15;536(Pt 2):521-31. (PMID: <searchLink fieldCode="PM" term="%2211600686%22">11600686)</searchLink><br />J Cereb Blood Flow Metab. 2017 May;37(5):1670-1686. (PMID: <searchLink fieldCode="PM" term="%2227356551%22">27356551)</searchLink><br />Epilepsia. 2019 Dec;60(12):2386-2397. (PMID: <searchLink fieldCode="PM" term="%2231755112%22">31755112)</searchLink><br />J Physiol. 2003 Oct 15;552(Pt 2):483-97. (PMID: <searchLink fieldCode="PM" term="%2214561831%22">14561831)</searchLink><br />Neuron. 2015 May 20;86(4):902-922. (PMID: <searchLink fieldCode="PM" term="%2225996134%22">25996134)</searchLink><br />Nat Commun. 2025 May 18;16(1):4619. (PMID: <searchLink fieldCode="PM" term="%2240383825%22">40383825)</searchLink><br />J Neurophysiol. 2005 Aug;94(2):943-51. (PMID: <searchLink fieldCode="PM" term="%2215800073%22">15800073)</searchLink><br />Nat Methods. 2024 May;21(5):914-921. (PMID: <searchLink fieldCode="PM" term="%2238589517%22">38589517)</searchLink><br />Electroencephalogr Clin Neurophysiol. 1951 Aug;3(3):315-21. (PMID: <searchLink fieldCode="PM" term="%2214879782%22">14879782)</searchLink><br />J Neurosci. 2021 Jan 27;41(4):766-779. (PMID: <searchLink fieldCode="PM" term="%2233229500%22">33229500)</searchLink><br />JAMA Neurol. 2020 Apr 1;77(4):489-499. (PMID: <searchLink fieldCode="PM" term="%2231886870%22">31886870)</searchLink><br />J Neurosci. 2016 Apr 27;36(17):4733-43. (PMID: <searchLink fieldCode="PM" term="%2227122032%22">27122032)</searchLink><br />Neurosci Lett. 1993 Apr 2;152(1-2):65-8. (PMID: <searchLink fieldCode="PM" term="%228515881%22">8515881)</searchLink><br />Cell Biochem Biophys. 2001;35(2):171-90. (PMID: <searchLink fieldCode="PM" term="%2211892790%22">11892790)</searchLink><br />Physiol Rev. 2015 Jul;95(3):953-93. (PMID: <searchLink fieldCode="PM" term="%2226133935%22">26133935)</searchLink><br />J Physiol. 2005 Nov 15;569(Pt 1):41-57. (PMID: <searchLink fieldCode="PM" term="%2216141270%22">16141270)</searchLink><br />Science. 1982 May 14;216(4547):745-7. (PMID: <searchLink fieldCode="PM" term="%227079735%22">7079735)</searchLink><br />Neurocrit Care. 2022 Jun;37(Suppl 1):31-48. (PMID: <searchLink fieldCode="PM" term="%2235174446%22">35174446)</searchLink><br />Physiol Rev. 2001 Jul;81(3):1065-96. (PMID: <searchLink fieldCode="PM" term="%2211427692%22">11427692)</searchLink>
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  Data: <i>Keywords: </i>action potential; cortex; local field potential; membrane potential; migraine; neuron; patch-clamp; single unit activity; spreading depolarization
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      – SubjectFull: Neurons physiology
        Type: general
      – SubjectFull: Somatosensory Cortex physiology
        Type: general
      – SubjectFull: Animals
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      – SubjectFull: Rats
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      – SubjectFull: Action Potentials physiology
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      – SubjectFull: Cortical Spreading Depression physiology
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      – TitleFull: Action Potential Dynamics During Spreading Depolarization.
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          Name:
            NameFull: Burkhanova-Zakirova G
      – PersonEntity:
          Name:
            NameFull: Khazipov R
      – PersonEntity:
          Name:
            NameFull: Nasretdinov A
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 28
              M: 03
              Text: 2026 Mar 28
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2073-4409
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Cells
              Type: main
ResultId 1