Academic Journal
Structural neuroimaging of the planning network in Inuit adolescents prenatally exposed to lead.
| Τίτλος: | Structural neuroimaging of the planning network in Inuit adolescents prenatally exposed to lead. |
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| Συγγραφείς: | Fornasier-Bélanger M; Département de Psychologie, Université du Québec à Montréal, 100, rue Sherbrooke Ouest, Montréal, Québec H2X 3P2, Canada; Centre de recherche du CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, Canada. Electronic address: fornasier-belanger.mathieu@courrier.uqam.ca., Muckle G; École de Psychologie, Université Laval, 2325, rue des Bibliothèques,Québec, Québec G1V 0A6, Canada; Axe santé des populations et pratiques optimales en santé, Centre de Recherche du CHU de Québec-Université Laval, Hôpital du St-Sacrement, 1050, Chemin Ste-Foy, Québec, Québec G1S 4L8, Canada., Ayotte P; Axe santé des populations et pratiques optimales en santé, Centre de Recherche du CHU de Québec-Université Laval, Hôpital du St-Sacrement, 1050, Chemin Ste-Foy, Québec, Québec G1S 4L8, Canada; Département de Médecine Sociale et Préventive, Faculté de Médecine, Université Laval, 1050, Avenue de la Médecine, Pavillon Ferdinand-Vandry, Québec, Québec G1V 0A6, Canada., Jacobson JL; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Drive, Detroit, MI 48201, United States., Jacobson SW; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Drive, Detroit, MI 48201, United States., Saint-Amour D; Centre de recherche du CHU Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, Montréal, Québec H3T 1C5, Canada; Université du Québec à Montréal, 320 Sainte-Catherine Est, Pavillon J.A. De Sève, Montréal, Québec H2X 1L7, Canada. Electronic address: saint-amour.dave@uqam.ca. |
| Πηγή: | Neurotoxicology [Neurotoxicology] 2026 May; Vol. 114, pp. 103449. Date of Electronic Publication: 2026 Apr 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : Amsterdam : Elsevier Science Original Publication: Park Forest South, Ill., Pathotox Publishers. |
| Ιατρικοί όροι (MeSH): | Prenatal Exposure Delayed Effects*/diagnostic imaging , Prenatal Exposure Delayed Effects*/psychology , Prenatal Exposure Delayed Effects*/chemically induced , Lead*/blood , Lead*/adverse effects , Executive Function*/drug effects , Brain*/diagnostic imaging , Brain*/drug effects , Inuit*, Fetal Blood/chemistry ; Humans ; Female ; Pregnancy ; Adolescent ; Magnetic Resonance Imaging ; Male ; Young Adult ; Neuroimaging |
| Περίληψη: | Exposure to lead has been linked to alterations in cortical organization and impaired executive function. However, neural correlates of the association between lead exposure and cognitive planning remain poorly characterized. This study investigated whether brain structures mediate the association between prenatal lead exposure and planning performance in late adolescence. Seventy-two Inuit participants (mean age = 18.4 years, range = 16.25-21.55 years) from Nunavik, Canada, completed the Tower of London planning task as well as a T1-weighted brain magnetic resonance imaging (MRI) scan to measure cortical thickness and surface area of key brain regions of the planning network. Prenatal exposure was estimated by measuring lead concentrations in cord blood samples at birth. Structural equation models tested the mediating role of regional brain structure in the association between prenatal lead exposure and cognitive planning, adjusting for sociodemographic characteristics and fish nutrients. Results showed that higher cord blood lead concentrations were associated with reduced cortical thickness in multiple regions of interest as well as smaller surface area in bilateral inferior parietal cortices. However, we found little evidence that these altered cortical metrics mediated the association between lead exposure and decreased cognitive planning. This study suggests that prenatal exposure to lead alters adolescent cortical structure within the planning network, primarily through reduced cortical thickness, but this effect was not sufficient to account for lower performance. Our findings highlight the impact of prenatal lead exposure on brain development, yet the neural bases of lead-related cognitive planning impairments remain unclear. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Adolescence; Brain; Cognitive planning; Development; Lead; Magnetic resonance imaging; Surface-based morphometry |
| Substance Nomenclature: | 2P299V784P (Lead) |
| Entry Date(s): | Date Created: 20260412 Date Completed: 20260611 Latest Revision: 20260615 |
| Update Code: | 20260616 |
| DOI: | 10.1016/j.neuro.2026.103449 |
| PMID: | 41967646 |
| Βάση Δεδομένων: | MEDLINE |
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