Academic Journal
Rigid control of motor unit firing rates in the human tibialis anterior muscle persists during neurofeedback.
| Τίτλος: | Rigid control of motor unit firing rates in the human tibialis anterior muscle persists during neurofeedback. |
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| Συγγραφείς: | Lee MJ; Bernstein Center Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany., Ofner P; Bernstein Center Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany., Huang HY; Department of Engineering and Design, University of Sussex, Brighton, United Kingdom.; Department of Bioengineering, Imperial College London, London, United Kingdom., Mulder J; Department of Methodology and Statistics, Tilburg University, Tilburg, The Netherlands., Ibañez J; Centro de Investigacion Biomedica en Red en Bioingeniera, Biomateriales y Nanomedicina, CIBER, Zaragoza, Spain.; BSICoS, I3A and IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain., Farina D; Department of Bioengineering, Imperial College London, London, United Kingdom., Mehring C; Bernstein Center Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.; BrainLinks-BrainTools, University of Freiburg, Freiburg im Breisgau, Germany. |
| Πηγή: | Journal of neurophysiology [J Neurophysiol] 2026 Jun 01; Vol. 135 (6), pp. 1499-1517. Date of Electronic Publication: 2026 Apr 09. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Bethesda Md : American Physiological Society Original Publication: Washington [etc.] |
| Ιατρικοί όροι (MeSH): | Muscle, Skeletal*/physiology , Muscle, Skeletal*/innervation , Recruitment, Neurophysiological*/physiology , Motor Neurons*/physiology , Neurofeedback*, Humans ; Male ; Female ; Adult ; Young Adult ; Electromyography ; Feedback, Sensory ; Action Potentials |
| Περίληψη: | The conventional framework of motor unit (MU) control assumes that MUs in a MU pool are constrained by a fixed recruitment order and a common input. This rigid control framework has been challenged by recent findings suggesting that MU activity could be flexibly modulated, potentially mediated by descending cortical inputs. In this study, rather than evaluating flexibility from the perspective of recruitment thresholds, we investigated control flexibility by assessing whether human participants can voluntarily modulate MU firing rates beyond rigid control constraints. Specifically, we examined whether participants could voluntarily modulate the firing rates of a pair of MUs from the tibialis anterior muscle during real-time feedback. Two tasks involving target reach with different visual feedback derived from the MUs' firing rates were conducted. In both tasks, there was no evidence that participants were able to change MU firing rates in a way that would violate rigid control robustly. Our findings demonstrate limited flexibility in MU control in human tibialis anterior muscle within single-session training, even when real-time MU activity feedback was provided. The results suggest that MU flexibility is not inherently present in the human lower limb.NEW & NOTEWORTHY How flexibly can the central nervous system control individual motor units? We tested whether humans can achieve independent control of pairs of motor units from the tibialis anterior muscle in two experiments with real-time visual feedback of motor unit firing rates. The results of both experiments provided no evidence of independent control. |
| Grant Information: | 899626 European Commission (EC); 810346 EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC); EP/T020970/1 UKRI | Engineering and Physical Sciences Research Council (SRC); INST 39/1014-1 Deutsche Forschungsgemeinschaft (DFG); Struktur- und Innovationsfonds Baden-Wuerttemberg (SI-BW); 101077693 EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC); CNS2022-135366 MCIN/AEI/10.13039/501100011033; UE's NextGenerationEU/PRTR |
| Contributed Indexing: | Keywords: common synaptic input; flexible control; motor unit; neurofeedback |
| Entry Date(s): | Date Created: 20260409 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260715 |
| DOI: | 10.1152/jn.00070.2025 |
| PMID: | 41956737 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1522-1598 |
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| DOI: | 10.1152/jn.00070.2025 |