Academic Journal
Flash glucose monitoring addition to self-monitoring of blood glucose and perinatal outcomes in gestational diabetes: a randomized controlled trial.
| Τίτλος: | Flash glucose monitoring addition to self-monitoring of blood glucose and perinatal outcomes in gestational diabetes: a randomized controlled trial. |
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| Συγγραφείς: | Zorko K; Clinical Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Munda A; Clinical Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Janež A; Clinical Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Pongrac Barlovič D; Clinical Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: drazenka.pongrac@kclj.si. |
| Πηγή: | American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2026 Aug; Vol. 235 (2), pp. 375-384. Date of Electronic Publication: 2026 Apr 02. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 0370476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6868 (Electronic) Linking ISSN: 00029378 NLM ISO Abbreviation: Am J Obstet Gynecol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2005->: New York : Elsevier Original Publication: St. Louis. |
| Ιατρικοί όροι (MeSH): | Diabetes, Gestational*/blood , Blood Glucose Self-Monitoring*/methods , Blood Glucose*/metabolism , Blood Glucose*/analysis, Fetal Macrosomia/epidemiology ; Humans ; Female ; Pregnancy ; Adult ; Continuous Glucose Monitoring ; Infant, Newborn ; Infant, Large for Gestational Age ; Pregnancy Outcome |
| Περίληψη: | Background: Self-monitoring of blood glucose represents the standard for glycemic monitoring in gestational diabetes mellitus, while the role of continuous glucose monitoring remains uncertain. Objective: To assess whether adjunctive flash glucose monitoring improves achievement of established self-monitored glucose targets compared with self-monitoring alone and to examine maternal and neonatal outcomes. Study Design: We conducted an open-label, single-center, randomized controlled trial comparing adjunctive flash glucose monitoring plus self-monitoring of blood glucose with self-monitoring of blood glucose alone. The prespecified primary outcome was the percentage of self-monitored glucose measurements within the established target range. Secondary outcomes included maternal and neonatal outcomes. Analyses followed the intention-to-treat principle. Results: A total of 205 women (median age, 32 years; median prepregnancy body mass index, 23.5 kg/m2; median gestational age, 27 weeks) were randomized (102 to adjunctive flash glucose monitoring and 103 to self-monitoring alone). The percentage of self-monitored glucose measurements within target range was lower in the adjunctive flash monitoring group (89.5% vs 92.6%, P=.04). Median fasting and 1-hour postprandial self-monitored glucose concentrations were comparable between groups and within recommended targets. The incidence of large-for-gestational-age infants was lower in the flash monitoring group (3% vs 11%; P=.05; odds ratio, 0.27; 95% confidence interval, 0.07-0.99). Conclusion: Adjunctive flash glucose monitoring did not improve glycemic outcome in this low-risk gestational diabetes population. However, it was associated with fewer large-for-gestational-age neonates, a secondary outcome that should be interpreted cautiously given the sample size and number of events. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: continuous glucose monitoring (CGM); flash glucose monitoring (FGM); gestational diabetes (GDM); large-for-gestational-age (LGA); perinatal outcomes; self-monitoring of blood glucose (SMBG); small-for-gestational-age (SGA) |
| Substance Nomenclature: | 0 (Blood Glucose) |
| Entry Date(s): | Date Created: 20260405 Date Completed: 20260717 Latest Revision: 20260824 |
| Update Code: | 20260824 |
| DOI: | 10.1016/j.ajog.2026.03.030 |
| PMID: | 41935728 |
| Βάση Δεδομένων: | MEDLINE |
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