Academic Journal
Oligosaccharide esters with neuroprotective activities isolated from the roots of Polygala tenuifolia Willd.
| Τίτλος: | Oligosaccharide esters with neuroprotective activities isolated from the roots of Polygala tenuifolia Willd. |
|---|---|
| Συγγραφείς: | Guo Y; School of Graduate, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Liu X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Ding M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Wang Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Xie P; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Zhang H; School of Graduate, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin University of Technology, Tianjin, 300384, China. Electronic address: zhanghb626@163.com., Jiang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China. Electronic address: yongjiang@bjmu.edu.cn. |
| Πηγή: | Phytochemistry [Phytochemistry] 2026 Aug; Vol. 248, pp. 114905. Date of Electronic Publication: 2026 Mar 31. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Polygala*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Plant Roots*/chemistry , Oligosaccharides*/chemistry , Oligosaccharides*/isolation & purification , Oligosaccharides*/pharmacology , Esters*/chemistry , Esters*/isolation & purification , Esters*/pharmacology, Hydrogen Peroxide/pharmacology ; Oxidative Stress/drug effects ; Humans ; Molecular Structure ; Structure-Activity Relationship |
| Περίληψη: | Nine previously undescribed oligosaccharide esters (1-9), designated as tenuifolioses I-IX, along with nine known analogues (10-18), were isolated from the roots of Polygala tenuifolia Willd. Structural characterization of the novel compounds was achieved through comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data. The absolute configuration of the sugars were determined by acid hydrolysis either coupled with chemical derivatization or optical detection. The neuroprotective potential of the isolated compounds was evaluated using the H (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Neuroprotective activity; Oligosaccharide esters; Polygala tenuifolia Willd.; Polygalaceae; SY5Y cells |
| Substance Nomenclature: | 0 (Neuroprotective Agents) 0 (Oligosaccharides) 0 (Esters) BBX060AN9V (Hydrogen Peroxide) |
| Entry Date(s): | Date Created: 20260404 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| DOI: | 10.1016/j.phytochem.2026.114905 |
| PMID: | 41933642 |
| Βάση Δεδομένων: | MEDLINE |
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