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Sensing performance of ScTiO3 film-based EIS arrays through co-sputtering for pH sensing and heart failure biomarker monitoring.

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Τίτλος: Sensing performance of ScTiO3 film-based EIS arrays through co-sputtering for pH sensing and heart failure biomarker monitoring.
Συγγραφείς: Pan TM; Department of Electronics Engineering, Chang Gung University, Taoyuan City, 33302, Taiwan; Division of Urology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, 33305, Taiwan. Electronic address: tmpan@mail.cgu.edu.tw., Kuo CY; Division of Urology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, 33305, Taiwan., Her JL; Division of Natural Science, Center for General Education, Chang Gung University, Taoyuan, 33302, Taiwan., Pang ST; Division of Urology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, 33305, Taiwan.
Πηγή: Talanta [Talanta] 2026 Aug 15; Vol. 306, pp. 129741. Date of Electronic Publication: 2026 Mar 30.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Elsevier
Original Publication: Oxford : Pergamon Press
Ιατρικοί όροι (MeSH): Heart Failure*/diagnosis , Heart Failure*/blood , Natriuretic Peptide, Brain*/analysis , Natriuretic Peptide, Brain*/blood , Titanium*/chemistry , Peptide Fragments*/analysis , Peptide Fragments*/blood , Biosensing Techniques*/methods, Biomarkers/analysis ; Biomarkers/blood ; Hydrogen-Ion Concentration ; Humans ; Semiconductors
Περίληψη: In this work, a ScTiO3 sensing film array was fabricated on a p-type Si substrate using a co-sputtering technique and subsequently integrated into electrolyte-insulator-semiconductor (EIS) platforms for both pH sensing and N-terminal pro-B-type natriuretic peptide (NT-proBNP) detection, a clinically important biomarker for heart failure (HF) diagnosis. To evaluate the structural, interfacial, and sensing characteristics, the films underwent RTA at temperatures between 600 and 800 °C. Extensive material characterization, including X-ray diffraction, X-ray photoelectron spectroscopy, Auger electron spectroscopy, transmission electron microscopy, and atomic force microscopy, revealed a strong correlation between the microstructural evolution of the ScTiO3 films and their sensing performance. Superior sensing characteristics were observed in the film annealed at 700 °C, which recorded the highest sensitivity (65.07 mV/pH) alongside impressive stability metrics, including a 0.26 mV/h drift rate and 1.2 mV hysteresis. Furthermore, to enable specific NT-proBNP detection, the ScTiO3 surface was first functionalized with APTES and then conjugated with EDC/NHS-activated antibodies, facilitating precise antigen-antibody interactions. The resulting ScTiO3-based array EIS biosensor demonstrated excellent analytical performance, delivering a high sensitivity of 10.84 mV/pCNT-proBNP over a wide dynamic detection range from 10-4 to 106 pg/mL. Collectively, these results highlight the strong potential of a ScTiO3 sensing film array as high-performance platforms for reliable pH monitoring and advanced biomedical diagnostics, particularly for sensitive and accurate NT-proBNP detection in HF applications.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Electrolyte-insulator-semiconductor (EIS); Heart failure (HF); N-terminal pro-BNP (NT-proBNP); ScTiO(3) sensing film array; pH sensor
Substance Nomenclature: 114471-18-0 (Natriuretic Peptide, Brain)
0 (pro-brain natriuretic peptide (1-76))
0 (Biomarkers)
D1JT611TNE (Titanium)
0 (Peptide Fragments)
Entry Date(s): Date Created: 20260403 Date Completed: 20260714 Latest Revision: 20260714
Update Code: 20260714
DOI: 10.1016/j.talanta.2026.129741
PMID: 41930847
Βάση Δεδομένων: MEDLINE
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